《Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity》 was written by Jakopec, Silvio; Pantalon Juraj, Natalija; Brozovic, Anamaria; Jadresko, Dijana; Peric, Berislav; Kirin, Srecko I.; Raic-Malic, Silvana. HPLC of Formula: 95-24-9 And the article was included in Applied Organometallic Chemistry on April 30 ,2022. The article conveys some information:
Ferrocene derivatives with mono- Py2NCH2Trz-1-R (8a-c; Py = 2-pyridyl, Trz = 1,2,3-triazol-5-yl; R = Fc, FcCH2, FcCHMe) and bis-1,2,3-triazolyl fc(CH2-1-TrzCH2NPy2)2(9, fc = 1,1′-ferrocenediyl) and ArN(CH2Trz-1-R)2 (10a-13c; R = Fc, FcCH2, FcCHMe; Ar = Ph, 2-benzothiazolyl, 6-chloro-2-benzothiazolyl, 6-nitro-2-benzothiazolyl) chelating groups were synthesized by regioselective copper(I)-catalyzed 1,3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determined, as well as the structures of complexes [Cu(8a)2](CF3SO3)2 (8a-Cu) and [Cu(8c)2(MeOH)2](BF4)2 (8c-Cu). In addition to NMR and UV-Vis spectroscopy, the metal complexes were characterized by cyclic voltammetry. The cytotoxic effect of ferrocene conjugates and their Zn(II) and Cu(II) complexes was explored, and cell cycle anal. was performed. The complex [Cu(8c)2](CF3SO3)2 showed the most prominent and selective cytotoxicity on cervical carcinoma (HeLa), ovarian cancer (MES-OV), non-small cell lung cancer (A549) and breast carcinoma (MDA-MB-231) cells. This complex increased cell population in the S and G2/M phase of the cell cycle, which was accompanied by an increase of the cells present in the sub-G0/G1 fraction. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica