Jin, Minye; Glaeser, Alisa; Paez, Julieta I. published the artcile< Redox-triggerable firefly luciferin-bioinspired hydrogels as injectable and cell-encapsulating matrices>, Product Details of C11H8N2O3S2, the main research area is luciferin bioinspired hydrogel injectable cell encapsulating matrix.
Stimuli-responsive hydrogels are smart materials that respond to variations caused by external stimuli and that are currently exploited for biomedical applications such as biosensing, drug delivery and tissue engineering. The development of stimuli-responsive hydrogels with defined user control is relevant to realize materials with advanced properties. Recently, our group reported firefly luciferin-inspired hydrogel matrixes for 3D cell culture. This platform exhibited advantages like rapid gelation rate and tunability of mech. and biol. properties. However, this first mol. design did not allow fine control of the gelation onset, which restricts application as a cell-encapsulating matrice with injectable and processable properties. In this article, we endow the firefly luciferin-inspired hydrogels with redox-triggering capability, to overcome the limitations of the previous system and to widen its application range. We achieve this goal by introducing protected macromers as hydrogel polymeric precursors that can be activated in the presence of a mild reductant, to trigger gel formation in situ with a high degree of control. We demonstrate that the regulation of mol. parameters (e.g., structure of the protecting group, reductant type) and environmental parameters (e.g., pH, temperature) of the deprotection reaction can be exploited to modulate materials properties. This redox-triggerable system enables precise control over gelation onset and kinetics, thus facilitating its utilization as an injectable hydrogel without neg. impacting its cytocompatibility. Our findings expand the current toolkit of chem.-based stimuli-responsive hydrogels.
Polymer Chemistry published new progress about Biocompatibility, cytocompatibility. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Product Details of C11H8N2O3S2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica