Kosaki, Yusuke; Ogawa, Narihito; Wang, Qian; Kobayashi, Yuichi published the artcile< Synthesis of Coronafacic Acid via TBAF-Assisted Elimination of the Mesylate and Its Conversion to the Isoleucine Conjugate>, Recommanded Product: (S)-4-Benzylthiazolidine-2-thione, the main research area is coronafacic acid preparation quaternary ammonium fluoride elimination mesylate; isoleucine conjugate coronafacic acid preparation.
An aldol reaction followed by elimination of the derived mesylate was used to construct the side chain that was designed to afford the cyclohexene ring of coronafacic acid via intramol. alkylation. Elimination of the mesylate proceeded with TBAF. The alkylation was achieved with t-BuOK in THF, and then hydrolysis afforded coronafacic acid, which upon condensation with unprotected L-isoleucine using ClCO2Bui furnished coronafacoyl-L-isoleucine, the L-Ile conjugate.
Organic Letters published new progress about Aldol addition. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Recommanded Product: (S)-4-Benzylthiazolidine-2-thione.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica