Lakhan, R.; Rai, B. J. published the artcile< Local anesthetics. IV. Synthesis and activity of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles>, Safety of 2-Amino-4-(3-nitrophenyl)thiazole, the main research area is local anesthetic aminoacetamidothiazole preparation; thiazole aminoacetamido anesthetic preparation.
I (R = H or Me, R1 and R2 = H or alkyl or NR1R2 = morpholino, R3 = H or m- or p-O2N) were prepared by treatment of the appropriate 2-chloroacetamidothiazole derivative with an appropriate amine. I(R = H, R1 = R2 = iso-Pr, R3 = m-O2N) [105602-34-4] and I (R = Me, R1 = R2 = Pr, R3 = H) [105602-33-3] (as HCl salt) were the most potent local onesthetics in comparison with procaine-HCl. All other I required a similar time n producing onset of anesthesia as procaine.
Farmaco, Edizione Scientifica published new progress about Local anesthetics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Safety of 2-Amino-4-(3-nitrophenyl)thiazole.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica