In 2018,Liu, Juan-Juan; Lu, Yan-Ju; Zhao, Zhen-Dong; Xu, Shi-Chao; Bi, Liang-Wu published 《Synthesis and Cytotoxic Activity of Amides from Isopimaric Acid》.Chemistry of Natural Compounds published the findings.Name: 5-Bromothiazol-2-amine The information in the text is summarized as follows:
The amide derivatives were synthesized from isopimaric acid and characterized by spectroscopy. These amides were examined in vitro for their cytotoxic activity against four cancer cell lines. The majority of the screened compounds displayed better inhibitory activity than isopimaric acid, and many amides displayed promising cytotoxic activity against hepatocarcinoma (HepG-2), breast carcinoma (MDA-MB-231), and prostate adenocarcinoma (PC-3). The substituent type, number, and position in the benzene and heterocyclic rings have an important influence on cytotoxicity against the three tested cancer cell lines. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Name: 5-Bromothiazol-2-amine)
5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 5-Bromothiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica