Product Details of 95-24-9On May 31, 2019, Yamano, Tomoyoshi; Dobes, Jan; Voboril, Matous; Steinert, Madlen; Brabec, Tomas; Zietara, Natalia; Dobesova, Martina; Ohnmacht, Caspar; Laan, Martti; Peterson, Part; Benes, Vladimir; Sedlacek, Radislav; Hanayama, Rikinari; Kolar, Michal; Klein, Ludger; Filipp, Dominik published an article in Journal of Experimental Medicine. The article was 《Aire-expressing ILC3-like cells in the lymph node display potent APC features》. The article mentions the following:
The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “”promiscuous”” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here, we report that Aire protein-expressing cells in lymph nodes exhibit typical group 3 innate lymphoid cell (ILC3) characteristics such as lymphoid morphol., absence of “”classical”” hematopoietic lineage markers, and dependence on RORγt. Aire+ cells are more frequent among lineage-neg. RORγt+ cells of peripheral lymph nodes as compared with mucosa-draining lymph nodes, display a unique Aire-dependent transcriptional signature, express high surface levels of MHCII and costimulatory mols., and efficiently present an endogenously expressed model antigen to CD4+ T cells. These findings define a novel type of ILC3-like cells with potent APC features, suggesting that these cells serve a function in the control of T cell responses. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Product Details of 95-24-9)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Product Details of 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica