Fahmy, H. T. Y.; Bekhit, A. A. published the artcile< Synthesis of some new bis-thiazoles as possible anticancer agents>, Reference of 10574-69-3, the main research area is rhodanine preparation antitumor agent.
Several new 5-(2,3-dihydrothiazol-2-ylidenyl)rhodanines I (R1 = Ph; R2 = Ph, 4-ClC6H4, 4-MeC6H4; R3 = H) and 5-(4-oxothiazolidinon-2-ylidenyl)rhodanine II were synthesized through the reaction of 5-thiocarbamoyl rhodanine III [R1 = Ph; R4 = C(S)NHPh] with phenacyl bromides or chloroacetic acid, resp. The synthesis of arylidenes IV (R5 = H, Cl, MeO) was also described. The 5-(4-amino-5-cyano-2,3-dihydrothiazol-2-ylidenyl)rhodanines I (R1 = Ph, CH2Ph; R2 = NH2; R3 = CN) were obtained through reaction of rhodanines III (R1 = Ph, CH2Ph; R4 = H) with a thiazolium salt. All the prepared compounds were screened for their anticancer activity using the in vitro anticancer screening program of the NCI. Three compounds showed promising anticancer activity against particular human cell lines used in the assay.
Pharmazie published new progress about Antitumor agents. 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Reference of 10574-69-3.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica