Yu, Dou; Li, Gina; Lesniak, Maciej S.; Balyasnikova, Irina V. published the artcile< Intranasal delivery of therapeutic stem cells to glioblastoma in a mouse model>, Quality Control of 115144-35-9, the main research area is intranasal administration stem cell therapy glioblastoma.
The intrinsic tropism towards brain malignancies renders stem cells as promising carriers of therapeutic agents against malignant tumors. The delivery of therapeutic stem cells via the intranasal route is a recently discovered alternative strategy, with strong potential for clin. translation, due to its non-invasive nature compared to intracranial implantation or delivery via systemic routes. The lack of blood brain barrier further strengthens the therapeutic potential of stem cells undergoing intranasal brain entry. This article summarizes the essential techniques utilized in our studies and outlines the basic principles of intranasal strategy for stem cell delivery using a mouse model of intracranial glioma xenografts. We demonstrate the optimized procedures that generate consistent and reproducible results with specific predetermined exptl. parameters and offer guidelines for streamlined work flow that ensure efficient execution and reliable exptl. outcome. The article is designed to serve as a baseline for further exptl. customization based on hypothesis, stem cell types, or tumor specifics.
Journal of Visualized Experiments published new progress about Adenoviral vectors. 115144-35-9 belongs to class thiazole, and the molecular formula is C11H7KN2O3S2, Quality Control of 115144-35-9.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica