Day: October 20, 2022

Arora, Amandeep; Teegardin, Kip A.; Weaver, Jimmie D. published their research in Organic Letters on August 7 ,2015. The article was titled 《Reductive Alkylation of 2-Bromoazoles via Photoinduced Electron Transfer: A Versatile Strategy to Csp2-Csp3 Coupled Products》.Reference of 2-Bromo-4-chlorobenzo[d]thiazole The article contains the following contents:

Access to Csp2-Csp3-coupled products is a challenging goal at the forefront of catalysis. The photocatalytic reductive coupling of aryl bromides with unactivated alkenes is introduced as a convenient method that circumvents any need for synthesis of sp3-hybridized coupling partners. The reaction takes place via photoinduced electron transfer from a tertiary amine to an aryl bromide that fragments to provide an aryl radical and subsequently reacts with an alkene to form a C-C bond. Conveniently, the amine also serves as the final reductant. The method is operationally simple, functional group tolerant, and takes place with selectivities that will allow it to be used in the context of complex mol. synthesis. The experimental process involved the reaction of 2-Bromo-4-chlorobenzo[d]thiazole(cas: 3622-40-0Reference of 2-Bromo-4-chlorobenzo[d]thiazole)

2-Bromo-4-chlorobenzo[d]thiazole(cas: 3622-40-0) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Reference of 2-Bromo-4-chlorobenzo[d]thiazoleTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,Nanomaterials included an article by Tanase, Corneliu; Berta, Lavinia; Coman, Nastaca Alina; Rosca, Ioana; Man, Adrian; Toma, Felicia; Mocan, Andrei; Nicolescu, Alexandru; Jakab-Farkas, Laszlo; Biro, Domokos; Mare, Anca. Related Products of 30931-67-0. The article was titled 《Antibacterial and antioxidant potential of silver nanoparticles biosynthesized using the spruce bark extract》. The information in the text is summarized as follows:

Biosynthesized silver nanoparticles (AgNPs) are widely used in Pharmacy and Medicine. In particular, AgNPs synthesized and mediated by plant extracts have shown to possess several biol. activities. In the present study, AgNPs were synthesized using Picea abies L. stem bark extract as reducing agent. Factors, such as metal ion solution, pH, and time, which play a role in the AgNPs synthesis, were assessed. The synthesized AgNPs were characterized by UV-Visible Spectrometry, Fourier transform IR spectroscopy, and Transmission Electron Microscopy (TEM). Further, the study has been extended to evaluate the antimicrobial and antioxidant activity of AgNPs. The broad peak obtained at 411-475 nm (UV-Vis spectroscopy), and the color change pattern, confirmed the synthesis of AgNPs. TEM results showed spherical or rarely polygonal AgNPs with an average size of 44 nm at pH = 9. The AgNPs showed antioxidant activity and antibacterial effect against human pathogenic Gram-pos. and Gram-neg. bacteria. The results show that spruce bark extract is suitable for obtaining AgNPs, with antibacterial and antioxidant activity. The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2021,Lab on a Chip included an article by Marquez, Augusto; Santos, Moliria V.; Guirado, Gonzalo; Moreno, Alex; Aznar-Cervantes, Salvador D.; Cenis, Jose Luis; Santagneli, Silvia H.; Dominguez, Carlos; Omenetto, Fiorenzo G.; Munoz-Berbel, Xavier. Recommanded Product: ABTS Diammonium. The article was titled 《Nanoporous silk films with capillary action and size-exclusion capacity for sensitive glucose determination in whole blood》. The information in the text is summarized as follows:

In optical biosensing, silk fibroin (SF) appears as a promising alternative where other materials, such as paper, find limitations. Besides its excellent optical properties and unmet capacity to stabilize biomacromols., SF in test strips exhibits addnl. functions, i.e. capillary pumping activity of 1.5 mm s-1, capacity to filter blood cells thanks to its small, but tuneable, porosity and enhanced biosensing sensitivity. The bulk functionalization of SF with the enzymes glucose oxidase and peroxidase and the mediator ABTS produces colorless and transparent SF films that respond to blood glucose increasing 2.5 times the sensitivity of conventional ABTS-based assays. This enhanced sensitivity results from the formation of SF-ABTS complexes, where SF becomes part of the bioassay. Addnl., SF films triple the durability of most stable cellulose-based sensors. Although demonstrated for glucose, SF microfluidic test strips may incorporate other optical bioassays, e.g. immunoassays, with the aim of transferring them from central laboratories to the place of patient’s care. In the experiment, the researchers used ABTS Diammonium(cas: 30931-67-0Recommanded Product: ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Recommanded Product: ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2022,Pharmaceuticals included an article by Moodley, Rashmika; Mashaba, Chakes; Rakodi, Goitsemodimo H.; Ncube, Nomagugu B.; Maphoru, Mabuatsela V.; Balogun, Mohammed O.; Jordan, Audrey; Warner, Digby F.; Khan, Rene; Tukulula, Matshawandile. Safety of 6-Chlorobenzothiazol-2-ylamine. The article was titled 《New Quinoline-Urea-BenzΞothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling》. The information in the text is summarized as follows:

A series of 25 new benzothiazole-urea-quinoline hybrid compounds, I (X = H, Me, F, NO2, etc.) and II (n = 0, 2, 3, 4, and 6) were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step. In vitro evaluation of these hybrid compounds for their antitubercular inhibitory activity against the Mycobacterium tuberculosis H37Rv pMSp12::GPF bioreporter strain was undertaken. Of the 25 tested compounds, 17 compounds exhibited promising anti-TB activities of less than 62.5μM (MIC90) and 13 compds showed promising activity with MIC90 values in the range of 1-10μM, while compound I(X = CF3), being the most active, exhibited sub-micromolar activity (0.968μM) in the CAS assay. In addition, minimal cytotoxicity against the HepG2 cell line (cell viability above 75%) in 11 of the 17 compounds, at their resp. MIC90 concentrations, was observed, with compound I(X = CF3), exhibiting 100% cell viability. The hybridization of the quinoline, urea, and benzothiazole scaffolds demonstrated a synergistic relationship because the activities of resultant hybrids were vastly improved compared to the individual entities. In silico ADME predictions showed that the majority of these compounds have drug-like properties and are less likely to potentially cause cardiotoxicity (QPlogHERG > -5).6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Safety of 6-Chlorobenzothiazol-2-ylamine) was used in this study.

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Safety of 6-Chlorobenzothiazol-2-ylamineThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pandey, Deepshikha; Daverey, Achlesh; Dutta, Kasturi; Arunachalam, Kusum published an article in Chemosphere. The title of the article was 《Bioremoval of toxic malachite green from water through simultaneous decolorization and degradation using laccase immobilized biochar》.Related Products of 30931-67-0 The author mentioned the following in the article:

In this study, decolorization and degradation of malachite green dye was studied using the laccase immobilized pine needle biochar. Successful immobilization of biochar was achieved by adsorption and confirmed through SEM and energy dispersive X-ray anal. (SEM-EDX), Fourier transform IR spectroscopy (FTIR). High laccase binding of 64.4 U/g and high immobilization yield of 78.1% was achieved using 4U of enzyme at pH3 and temperature 30 °C. The immobilized laccase retained >50% relative activity in the pH range 2-7, >45% relative activity at 65 °C and >55% relative activity at 4 °C for 4 wk. The re-usability of immobilized enzyme was checked with 2, 2′-azino-bis 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) substrate and enzyme retained 53% of its activity after 6 cycles. Immobilized laccase was used for the degradation and decolorization of azo dye malachite green in aqueous solution More than 85% removal of malachite green dye (50 mg/L) was observed within 5 h. FTIR and high performance liquid chromatog. (HPLC) anal. clearly indicated the breakdown of dye and presence of metabolites (leuco malachite green, methanone, [4-(di-Me amino)pheny]phenyl and 3-dimethyl-Ph amine) in gas chromatog.-mass spectrometry (GC-MS) anal. confirmed the dye degradation Phytotoxicity anal. indicated that the enzymic degradation resulted in lesser toxic metabolites than the original dye. Thus, laccase immobilized biochar can be used as an efficient biocatalytic agent to remove dye from water. The experimental part of the paper was very detailed, including the reaction process of ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Design, synthesis and evaluation of benzothiazole urea derivatives as an anticonvulsant agent》 were Kachare, Snehal D.; Baheti, Kamalkishor G.; Yasar, Qazi; Jangam, Sampada S.. And the article was published in Pharma Chemica in 2021. Application of 95-24-9 The author mentioned the following in the article:

A series of 1-((-6-substituted-2-yl)-3-(4H-1,2,4 triazole-3-yl))ureas I (R = H, OMe, Cl, NO2, etc.) and (1-((3-(6-substituted-2-yl)ureido)methyl)cyclohexyl)acetic acids II were designed, synthesized using appropriate synthetic route and screened for CNS depressant and anticonvulsant activities. The synthesized compounds I and II were also analyzed for ADME properties. The results of In-Silico ADME Screening showed that compounds I and II could be exploited as an oral drug candidate. Mol. docking studies were performed for all the synthesized compounds I and II against γ-amino butyric acid amino transferase enzyme (1OHV), and all the compounds I and II exhibited docking score in the range of -7.5 to -8.4, among which compound II (R = Cl) had shown the highest docking scores as compared to the standard drug phenytoin. Animal study for anticonvulsant indicated that compounds I (R = NO2, H) and II (R = Cl) were exhibited significant activity at a dose 200 mg/kg. All these compounds I and II were also evaluated for CNS depressant activity using actophotometer. The results of CNS depressant and anticonvulsant activities and docking study showed that synthesized compounds I and II had potential CNS depressant and anticonvulsant activities and can be further optimized and developed as a lead compound The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application of 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Lu; Wang, Huaiyu; Meng, Weidong; Xu, Xiu-Hua; Huang, Yangen published an article on January 31 ,2021. The article was titled 《Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization》, and you may find the article in Chinese Chemical Letters.Recommanded Product: 6-Chlorobenzothiazol-2-ylamine The information in the text is summarized as follows:

The 3-CF3S substituted thioflavones I (R1 = C6H5, 4-ClC6H4, 2-thienyl, etc.; R2 = Br) and benzothiophenes II (R3 = C6H5, 4-FC6H4, 2-thienyl, etc.; R4 = 6-Me, 6-Cl, 4,6-(Cl)2, etc.) were achieved via the reactions of AgSCF3 with methylthiolated alkynones 2-(SMe)-5-BrC6H3C(O)CCR1 and alkynylthioanisoles, R5CCR3 (R5 = 4-chloro-2-(methylsulfanyl)phenyl, 5-methyl-2-(methylsulfanyl)phenyl, 2,4-difluoro-6-(methylsulfanyl)phenyl, etc.) resp., promoted by persulfate. This protocol possesses good functional group tolerance and high yields. Mechanistic studies suggested that a classic two-step radical process involves addition of CF3S radical to triple bond and cyclization with SMe moiety. After reading the article, we found that the author used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 6-Chlorobenzothiazol-2-ylamineTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Xing, Yanyan; Chen, Meiling; Zhao, Yunkun; Xu, Jiabi; Hou, Xiaohong published an article on January 31 ,2022. The article was titled 《Triple-enzyme mimetic activity of Fe3O4 @C@MnO2 composites derived from metal-organic frameworks and their application to colorimetric biosensing of dopamine》, and you may find the article in Microchimica Acta.Formula: C18H24N6O6S4 The information in the text is summarized as follows:

Novel Fe3O4 @C@MnO2 composites were successfully synthesized for the first time via an interfacial reaction between magnetic porous carbon and KMnO4, in which the magnetic porous carbon was derived from the pyrolysis of Fe-MIL-88A under N2 atmosphere. Interestingly, the obtained Fe3O4 @C@MnO2 composites were found to have triple-enzyme mimetic activity including peroxidase-like, catalase-like, and oxidase-like activity. As a peroxidase mimic, Fe3O4 @C@MnO2 composites could catalyze the oxidation of TMB into a blue oxidized product by H2O2. As a catalase mimic, Fe3O4 @C@MnO2 could catalyze the decomposition of H2O2 to generate O2 and H2O. As an oxidase mimic, Fe3O4 @C@MnO2 could catalyze the direct oxidation of TMB to produce a blue oxidized product without H2O2. Reactive oxygen species measurements revealed that the oxidase-like activity originated from 1O2 and O2-•and little•OH generated by the dissolved oxygen, which was catalyzed by the Fe3O4 @C@MnO2 in the TMB oxidation reaction. The oxidase-like activity of Fe3O4 @C@MnO2 was investigated in detail. Under the optimized conditions, a rapid, sensitive, visual colorimetric method for dopamine detection was developed based on the inhibitory effect of dopamine on the oxidase-like activity. The proposed method allows for dopamine detection with a limit of detection of 0.034μM and a linear range of 0.125-10μM. This new colorimetric method was successfully used for the determination of dopamine in human blood samples. In the experiment, the researchers used ABTS Diammonium(cas: 30931-67-0Formula: C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Formula: C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Amino acid profile and biological properties of silk cocoon as affected by water and enzyme extraction》 was published in Molecules in 2021. These research results belong to Bungthong, Chuleeporn; Wrigley, Colin; Sonteera, Thanathat; Siriamornpun, Sirithon. Electric Literature of C18H24N6O6S4 The article mentions the following:

We compared the efficacy for protein extraction of water vs. enzymic extraction The amino-acid composition, inhibitory activity against enzymes α-amylase and a-glucosidase, and anti-glycation activities of silk protein extract (SPE) were determined We used water extraction (100°C, six hours) and protease-enzymic extraction The microstructure of silk fibers was obviously different after extraction The results showed that enzymic extraction gave the greater values of protein content, amino acids, total phenolic content (TPC), and total flavonoid content (TFC), as well as all biol. activities parameters tested, but it also provided a more bitter taste in the extract-contributing amino acids of 51% (arginine, phenylalanine, histidine, valine, tryptophan, isoleucine, and leucine) and less sweet and umami taste contributing amino acids than did water extraction, which could be more suitable to be used as concentrated nutraceuticals. In addition to this study using ABTS Diammonium, there are many other studies that have used ABTS Diammonium(cas: 30931-67-0Electric Literature of C18H24N6O6S4) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Electric Literature of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Biofabrication and characterization of cyanobacteria derived ZnO NPs for their bioactivity comparison with commercial chemically synthesized nanoparticles》 was written by Asif, Nida; Fatima, Samreen; Aziz, Nafe Md.; Shehzadi; Zaki, Almaz; Fatma, Tasneem. Related Products of 30931-67-0 And the article was included in Bioorganic Chemistry on August 31 ,2021. The article conveys some information:

Due to unique properties of the nanoparticles (NPs) with biocompatibility, their application as drug in drug delievery and diagnostics, the recent scientific branch nanotechnol. has emerged as hope in modern medicine. Zinc oxide nanoparticles (ZnO NPs) have gained tremendous interest due to their potential use as chemotherapeutic and antimicrobial agents. They are included in the category of “”generally recognized as safe (GRAS) metal oxide””. There is an urgent need for developing addnl. sources of ZnO NPs. Therefore, in the present study 30 cyanobacterial extracts were screened for ZnO NPs synthesis.. The color change of the reaction mixture from blue to pale white indicated the synthesis of ZnO NPs. It was further confirmed by UV-Visible spectroscopy that showed the absorption peak at 372 nm. The SEM anal. during screening revealed that Oscillatoria sp. synthesized smallest ZnO NPs (∼40 nm) that were further optimized for their higher yield by altering reaction conditions (pH, temperature, reaction time, concentration of extract and metal precursor). Best conditions for ZnO NPs synthesis are (0.02 M zinc nitrate, 10 mL of extract volume, pH 8, at 80°C for 3 h). The NPs were purified through calcination at 350°C and characterized by UV-Vis, FTIR, XRD, SEM-EDAX, TEM, Zeta potential and DLS anal. The comparative anal. of purified biogenic ZnO NPs with com. chem. synthesized ZnO NPs (CS), exhibited their superior nature as antioxidant and anti-bacterial agent against both gram-pos. and gram-neg. bacteria. Synergistic effects of biogenic ZnO NPs and streptomycin addnl. favored for their future use as a potential biomedical agent. The experimental process involved the reaction of ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica