Chen, Binhui; Guo, Shanshan; Guo, Xiao; Zhang, Guolin; Yu, Yongping published the artcile< Selective Access to 4-Substituted 2-Aminothiazoles and 4-Substituted 5-Thiocyano-2-aminothiazoles from Vinyl Azides and Potassium Thiocyanate Switched by Palladium and Iron Catalysts>, Formula: C9H7N3O2S, the main research area is aminothiazole preparation; thiocyanoaminothiazole preparation; palladium iron catalyst vinyl azide reaction potassium thiocyanate; thiazole amino preparation.
A highly selective construction of 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles, resp., catalyzed by palladium(II) acetate and promoted by iron(III) bromide from vinyl azides and potassium thiocyanate has been developed. E.g., reaction of PhC(:CH2)N3 with potassium thiocyanate, catalyzed by palladium(II) acetate gave 90% 2-aminothiazole derivative (I). Use of readily available starting materials, high selectivity, as well as mild reaction conditions make this practical method particularly attractive.
Organic Letters published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent) (vinyl). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Formula: C9H7N3O2S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica