Li, Xianlin; Tu, Zhenchao; Li, Hua; Liu, Chunping; Li, Zheng; Sun, Qiao; Yao, Yiwu; Liu, Jinsong; Jiang, Sheng published the artcile< Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with Click chemistry>, Product Details of C12H18N2O4S, the main research area is cyclic peptide design synthesis largazole HDAC inhibitor structure activity; mol docking largazole HDAC enzyme active site crystal structure; thiazole ester Corey Fuchs reaction cycloaddition Click chem macrocyclization; HDAC inhibitor; click chemistry; largazole; macrocycles; peptides.
We report the design, synthesis, and biol. evaluation of a new series of largazole analogs in which a 4-methylthiazoline moiety was replaced with a triazole and tetrazole ring, resp. Compound (I) bearing a tetrazole ring was identified to show much better selectivity for HDAC1 over HDAC9 than largazole (10-fold). This work could serve as a foundation for further exploration of selective HDAC inhibitors using a largazole mol. scaffold.
ACS Medicinal Chemistry Letters published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Product Details of C12H18N2O4S.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica