Mor, Satbir; Khatri, Mohini; Punia, Ravinder; Kumar, Deepak; Jindal, Deepak Kumar; Basu, Biswarup; Jakhar, Komal published their research in Journal of Molecular Structure on December 5 ,2022. The article was titled 《Synthesis and in vitro anticancer evaluation of 8b-hydroxy-1-(6-substitutedbenzo[d]thiazol-2-yl)-3-(3-substitutedphenyl)-1,8b-dihydroindeno[1,2-c]pyrazol-4(3aH)-ones》.SDS of cas: 95-24-9 The article contains the following contents:
A series of 1,8b-dihydroindeno[1,2-c]pyrazol-4(3aH)-ones I (R1 = Me, OMe, Br; R2 = H, Me, OMe, Cl, Br) has been efficiently syn.thesized on reaction of 2-(3-substitutedbenzoyl)-(1H)-indene-1,3(2H)-diones and 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substituted benzo[d]thiazoles in presence of dry ethanol under reflux conditions in good yields. The synthesized hydroxypyrazolones were assayed for their anticancer activity against two human cancer cell lines (i) lung carcinoma (A549) and (ii) breast carcinoma (MCF7) using MTT assay. Among all the tested compounds, I (R1 = Me; R2 = Cl) and I (R1 = Br; R2 = H) with IC50 values in the range of 30.68 +/- 0.57μM to 34.87 +/- 0.76μM exhibited moderate inhibitory ability against both the tested cancer cell lines in comparison to the standard drug Doxorubicin (0.95 +/- 0.10μM for A549 and 1.09 +/- 0.11μM for MCF7). The above two compounds were further tested against normal human embryonic kidney cell line (HEK 293T) to examine their toxicity against normal cell lines. Selectivity Index (S.I.) of these compounds was calculated for both the cancer cell lines which revealed that these derivatives i.e. I (R1 = Me; R2 = Cl) (S.I = 2.82 for A549 and 2.90 for MCF7) and I (R1 = Br; R2 = H) (S.I = 2.78 for A549 and 2.95 for MCF7) are safer anticancer agents. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica