Application In Synthesis of 6-Chlorobenzothiazol-2-ylamineOn October 26, 2021 ,《An efficient one-pot synthesis of 2-aminobenzothiazoles from substituted anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O》 was published in Tetrahedron Letters. The article was written by Dass, Reuben; Peterson, Matt A.. The article contains the following contents:
Treatment of anilines with benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O at 70°C gave the 2-aminobenzothiazoles I [R = 6-F, 6-Me, 4-F, etc.] in excellent isolated yields (75-97% and ave. yield for all substrates is 90%). The reaction worked well for 2(4)mono-2,4-di- or 3,4,5-tri-substituted anilines and a wide range of both electron donating groups (MeO, HO, CF3O, Me) and electron withdrawing groups (NO2, CN, CO2Et, CO2H, Cl, F) were well tolerated. This method provided a useful alternative to other methods that are either less efficient (requiring 3-7 fold equivalent of reagents) or utilize highly toxic and corrosive liquid Br2 as the oxidizing agent. The experimental part of the paper was very detailed, including the reaction process of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application In Synthesis of 6-Chlorobenzothiazol-2-ylamine)
6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application In Synthesis of 6-Chlorobenzothiazol-2-ylamineThiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica