Day: October 21, 2022

《Revealing the active site of gold nanoparticles for the peroxidase-like activity: the determination of surface accessibility》 was published in Catalysts in 2019. These research results belong to Liu, Ching-Ping; Chen, Kuan-Chung; Su, Ching-Feng; Yu, Po-Yen; Lee, Po-Wei. Related Products of 30931-67-0 The article mentions the following:

Despite the fact that the enzyme-like activities of nanozymes (i.e., nanomaterial-based artificial enzymes) are highly associated with their surface properties, little is known about the catalytic active sites. Here, we used the sulfide ion (S2-)-induced inhibition of peroxidase-like activity to explore active sites of gold nanoparticles (AuNPs). The inhibition mechanism was based on the interaction with Au(I) to form Au2S, implying that the Au(I) might be the active site of AuNPs for the peroxidase-like activity. XPS anal. showed that the content of Au(I) on the surface of AuNPs significantly decreased after the addition of S2-, which might be contributed to the more covalent Au-S bond in the formation of Au2S. Importantly, the variations of Au(I) with and without the addition of S2- for di erent surface-capped AuNPs were in good accordance with their corresponding peroxidase-like activities. These results confirmed that the accessible Au(I) on the surface was the main requisite for the peroxidase-like activity of AuNPs for the first time. In addition, the use of S2- could assist to determine available active sites for di erent surface modified AuNPs. This work not only provides a new method to evaluate the surface accessibility of colloidal AuNPs but also gains insight on the design of efficient AuNP-based peroxidase mimics. After reading the article, we found that the author used ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,Molecules included an article by Avato, Pinarosa; Argentieri, Maria Pia. Computed Properties of C18H24N6O6S4. The article was titled 《Quality assessment of commercial spagyric tinctures of Harpagophytum procumbens and their antioxidant properties》. The information in the text is summarized as follows:

Preparations from the dried tubers of Harpagophytum procumbens (Burch.) DC ex Meisn, commonly known as devil’s claw, are mainly used in modern medicine to relieve joint pain and inflammation in patients suffering from rheumatic and arthritic disorders. This paper describes for the first time the chem. profile of a com. spagyric tincture (named 019) prepared from the roots of the plant. For comparison purposes, a com. not-spagyric devil’s claw tincture (NST) was also analyzed. Chem. investigation of the content of specialized metabolites in the three samples indicated that harpagoside was the main compound, followed by the two isomers acteoside and isoacteoside. Compositional consistence over time was obtained by the chem. fingerprinting of another spagyric tincture (named 014) from the same producer that was already expired according to the recommendation on the label of the product. The two spagyric preparations did not show significant compositional differences as revealed by HPLC and MS analyses, except for a decrease in harpagide content in the expired 014 tincture. Moreover, their antioxidant capacities as assessed by 2,2′-di-phenyl-1-picrylhydrazyl (DPPH) and 2.2′-azin-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods resulted in very similar IC50 values. The expired 014 tincture showed instead a lower IC50 value compared to the 019 and NST tinctures with the ferric reducing antioxidant potential (FRAP) assay, indicating a higher ferric-reducing antioxidant ability. Overall, these results indicated that the two preparations could generally maintain good stability and biol. activity at least for the four years from the production to the expiration date. In the experiment, the researchers used many compounds, for example, ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,Molecules included an article by Zlotek, Urszula; Szymanowska, Urszula; Pecio, Lukasz; Kozachok, Solomiia; Jakubczyk, Anna. Related Products of 30931-67-0. The article was titled 《Antioxidative and potentially anti-inflammatory activity of phenolics from lovage Leaves Levisticum officinale koch elicited with jasmonic acid and yeast extract》. The information in the text is summarized as follows:

The effect of elicitation with jasmonic acids (JA) and yeast extract (YE) on the production of phenolic compounds as well as the antioxidant and anti-inflammatory properties of phenolic extracts of lovage was evaluated. The anal. of phenolic compounds carried out with the UPLCMS technique indicated that rutin was the dominant flavonoid, while 5-caffeoylquinic acid was the main component in the phenolic acid fraction in the lovage leaves. The application of 10μM JA increased the content of most of the identified phenolic compounds The highest antioxidant activities estimated as free radical scavenging activity against ABTS (2,2′-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid)) and reducing power were determined for the sample elicited with 10μM JA, while this value determined as iron chelating ability was the highest for the 0.1% YE-elicited lovage. The 0.1% and 1% YE elicitation also caused significant elevation of the lipoxygenase (LOX) inhibition ability, while all the concentrations of the tested elicitors significantly improved the ability to inhibit cyclooxygenase 2 (COX2) (best results were detected for the 10μM JA and 0.1% YE2 sample). Thus, 0.1% yeast extract and 10μM jasmonic acid proved to be most effective in elevation of the biol. activity of lovage. In the experiment, the researchers used ABTS Diammonium(cas: 30931-67-0Related Products of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Li, Guoliang; He, Yundong; Zhou, Wenbo; Wang, Peng; Zhang, Yong; Tong, Weiguang; Wu, Haigang; Liu, Mingyao; Ye, Xiyun; Chen, Yihua published an article on February 1 ,2014. The article was titled 《Identification, synthesis and photo-protection evaluation of arylthiazole derivatives as a novel series of sunscreens》, and you may find the article in Heterocycles.Recommanded Product: 144060-98-0 The information in the text is summarized as follows:

A series of arylthiazole derivatives I [R3 = C6H5, C6H5CH2, C6H5CH2CH2], II [R1 = C6H5, 4-BrC6H4, 3-H3COC6H4, 2-H3COC6H4], III [n= 1, 2, 3, 5; R = H, n-Pr, n-Bu, Et; R2 = OMe, OEt] and IV [R1 = H, CF3, OMe, Cl; R2 = H, Cl; R3 = H, Cl] was designed and synthesized. Addnl., phenylfuran derivative V [X = O; Y = C; R = H], phenylthiophene derivative V [X = S; Y = C; R = H], phenyloxazole derivative V [X = O; Y = N; R = Me], N-(Ethoxycarbonylmethyl)-2-phenyl-4-thiazolecarboxamide and N-(Ethoxycarbonylmethyl)-3-phenyl-5-methyl-4-isooxazolecarboxamide were also prepared All the synthesized compounds were evaluated for their photo-protective effect against UVB exposure induced cellular damage in keratinocytes cell (HaCaT) and their structure-activity relationship (SAR) was discussed. Among the tested compounds, compound III [n = 1; R = Et; R2 = OEt] significantly protected the dorsal skin of BALB/c-nu mice against UVB-induced decrustation in vivo. The in vitro and in vivo data for these arylthiazole derivatives suggest further studies for their potential use as photo-protection agents as well as sunscreen candidates. After reading the article, we found that the author used 4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0Recommanded Product: 144060-98-0)

4-Methyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(cas: 144060-98-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Recommanded Product: 144060-98-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Quality Control of ABTS DiammoniumOn October 15, 2019 ,《Reactivity of chromophoric dissolved organic matter (CDOM) to sulfate radicals: Reaction kinetics and structural transformation》 was published in Water Research. The article was written by Zhang, Suona; Rouge, Valentin; Gutierrez, Leonardo; Croue, Jean-Philippe. The article contains the following contents:

SO4·- would selectively react with electron rich moieties in DOM, known as chromophoric DOM (CDOM), due to its light absorbing property. In this study, the reactivity and typical structural transformation of CDOM with SO·-4 was investigated. Four well characterized hydrophobic DOM fractions extracted from different surface water sources were selected as model CDOM. SO4·- was produced through the activation of peroxymonosulfate (PMS) by Co(II) ions at pH 8 in borate buffer. The reactivity of CDOM changed with time where fast and slow reacting CDOMs (i.e., CDOMfast and CDOMslow) were clearly distinguished. A second-order rate constant of CDOMfast with SO·-4 was calculated by plotting UVA254 decrease vs. PMS exposure; where a Rct value (i.e., ratio of sulfate radical exposure to PMS exposure) was calculated using pCBA as a probe compound The transformation of CDOM was studied through the anal. of the changes in UVA254, electron donating capacity, fluorescence intensity, and total organic carbon. A transformation pathway leading to a significant carbon removal was proposed. This new knowledge on the kinetics and transformation of CDOM would ultimately assist in the development and operation of SO·-4-based water treatment processes. The results came from multiple reactions, including the reaction of ABTS Diammonium(cas: 30931-67-0Quality Control of ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Quality Control of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2019,ChemistrySelect included an article by Jafari, Behzad; Jalil, Saquib; Zaib, Sumera; Safarov, Sayfidin; Khalikova, Muattar; Ospanov, Meirambek; Yelibayeva, Nazym; Abilov, Zharylkasyn A.; Turmukhanova, Mirgul Z.; Kalugin, Sergey N.; Ehlers, Peter; Iqbal, Jamshed; Langer, Peter. Name: 6-Chlorobenzothiazol-2-ylamine. The article was titled 《Synthesis and Inhibitory Activity towards Monoamine Oxidase A and B of 8-Functionalized 3-Fluoro-2-methyl-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones》. The information in the text is summarized as follows:

An 8-chloro-3-fluoro-2-methyl-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one was synthesized and employed in various palladium catalyzed cross-coupling-reactions, including Suzuki-Miyaura, Sonogashira and Buchwald-Hartwig reactions, delivering 8-aryl- I (R = C6H5, 4-FC6H4, 3-CH3C6H4, etc.), 8-alkynyl- I (R = CCC6H5, 4-CH3C6H4CC, 4-(CH3)3CC6H4CC) and 8-amino-3-fluoro-2-methyl-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones I (R = morpholin-4-yl, (4-fluorophenyl)aminyl, phenylaminyl, etc.) in good to excellent yields. The synthesized derivatives I were analyzed for their monoamine oxidase (MAO-A and MAO-B) inhibitory potential. Most of the compounds I exhibited moderate to good inhibitory activity towards MAO-A and/or MAO-B. Docking anal. was performed to verify the exptl. results. Hence, 8-substituted-3-fluoro-2-methyl-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones I might be potential lead compounds towards novel monoamine oxidase inhibitors. In the experimental materials used by the author, we found 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Name: 6-Chlorobenzothiazol-2-ylamine)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Name: 6-Chlorobenzothiazol-2-ylamineThe thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Zeshuai; Wang, Zhiqiang; Li, Zheng published an article in Organic Letters. The title of the article was 《Three-Component One-Pot Construction of 2-Aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines Using Solid Calcium Carbide as a Surrogate of Gaseous Acetylene》.HPLC of Formula: 95-24-9 The author mentioned the following in the article:

A concise method for the construction of 2-aryl-4H-benzo[4,5]thiazolo[3,2-a]pyrimidines I (R = H, Cl, OMe; R1 = Ph, naphthalen-2-yl, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.) using solid calcium carbide instead of gaseous acetylene as an alkyne source and 2-aminobenzothiazoles II and aromatic aldehydes R1CHO as substrates through one-pot three-component cascade reactions is described. The salient features for this protocol are the use of an inexpensive and easy-to-handle alkyne source, noble-metal-free condition, wide substrate scope and functional tolerance, satisfactory yield, and simple workup procedure. After reading the article, we found that the author used 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines》 was published in Chemical Science in 2019. These research results belong to Jarrige, Lucie; Glavac, Danijel; Levitre, Guillaume; Retailleau, Pascal; Bernadat, Guillaume; Neuville, Luc; Masson, Geraldine. Recommanded Product: 95-24-9 The article mentions the following:

A highly efficient catalytic enantioselective [4+2] cycloaddition was developed between 2-benzothiazolimines and enecarbamates. A wide range of benzothiazolopyrimidines bearing three contiguous stereogenic centers was obtained in high to excellent yields and with excellent diastereo- and enantioselectivities (d.r. > 98 : 2 and up to >99% ee). Furthermore, this chiral phosphoric acid-catalyzed strategy was scalable and enabled access to a new class of optically pure Lewis base isothiourea derivatives The results came from multiple reactions, including the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Recommanded Product: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Recommanded Product: 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Lactobacillus bulgaricus improves antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus: a randomized control trial》 was written by Si, Lihui; Lin, Ruixin; Jia, Yan; Jian, Wenwen; Yu, Qing; Wang, Min; Yang, Shuli. Application of 30931-67-0 And the article was included in Bioscience Reports on August 30 ,2019. The article conveys some information:

Lactobacillus bulgaricus may improve antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus (GDM). Black garlic was prepared with or without L. bulgaricus. Volatile and polysaccharides were analyzed by using LC-MS, Fourier Transform IR (FTIR) and 13C NMR (NMR). The study design was parallel randomized controlled trial and 226 GDM patients were randomly assigned into BG (black garlic and L. bulgaricus) and CG (black garlic) groups, and allocation ratio was 1:1. The treatment duration was 40 wk. Fasting blood glucose (FBG) and 1- and 2-h blood glucose (1hBG and 2hBG) after oral glucose tolerance test (OGTT) were detected. Antioxidant function of black garlic was determined by measuring plasma malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and total antioxidant capacity (T-AOC) in GDM patients. The comparison between two groups was made using two independent samples t test. The intake of nutrients was similar between two groups (P>0.05). L. bulgaricus promoted the transformation of the glucopyranoside to glucofuranoside. L. bulgaricus increased the abilities of black garlic for scavenging hydroxyl radicals, 2,2′-azino-bis (3-ethylbenzenthiazoline-6-sulfonic) acid (ABTS) and DPPH free radicals. L. bulgaricus reduced the levels of FBG, 1hBG and 2hBG, and incidence of perinatal complications (P<0.01). Plasma MDA level in the BG group was lower than in the CG group, whereas the levels of SOD, GSH-PX and T-AOC in the BG group were higher than in the CG group (P<0.01). L. bulgaricus improves antioxidant capacity of black garlic in the prevention of GDM. In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0Application of 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Application of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Phenolic compounds and antioxidant and antibacterial activities of Algerian honeys》 was written by Otmani, Amar; Amessis-Ouchemoukh, Nadia; Birinci, Ceren; Yahiaoui, Sonia; Kolayli, Sevgi; Rodriguez-Flores, Maria Shantal; Escuredo, Olga; Seijo, Maria Carmen; Ouchemoukh, Salim. Product Details of 30931-67-0 And the article was included in Food Bioscience on August 31 ,2021. The article conveys some information:

Twenty-six samples of Algerian honeys were analyzed to determine their color intensity, content of bioactive compounds using colorimetric methods and phenolic profile using a high-performance liquid chromatog.-UV (HPLC-UV) anal. The antioxidant activities of the samples were estimated using 6 methods (1,1-diphenyl-2-picrilhydrazyl and 2,2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid free radicals scavenging, reducing power, chelating ferrous activity, nitric oxide radical scavenging assay and β-carotene bleaching) and the antibacterial power was determined in vitro using agar diffusion tests and measuring minimal inhibitory concentration The color of honeys ranged from light yellow to dark amber with an intensity ranging from 350 to 1510 mAU. The highest content of total polyphenols, flavonoids, carotenoids and vitamin C and the best antioxidant activity was obtained from dark honeys. Sixteen phenolic compounds (8 phenolic acids and 8 flavonoids) were quantified. The antibacterial tests showed that Staphylococcus aureus was the most sensitive strain compared to Salmonella typhi. The results allowed establishing a quant. phenolic profile of Algerian honeys. The bioactive compounds, the antioxidant and antibacterial activities, of honey did not depend on its monofloral or polyfloral nature, but rather on the type of flowers foraged by the bees and its geog. origin. The dark color of honey is a good indicator of a higher antioxidant content and the best biol. properties.ABTS Diammonium(cas: 30931-67-0Product Details of 30931-67-0) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Product Details of 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica