On October 5, 2000, Bizzarro, Fred Thomas; Corbett, Wendy Lea; Focella, Antonino; Grippo, Joseph Francis; Haynes, Nancy-ellen; Holland, George William; Kester, Robert Francis; Mahaney, Paige E.; Sarabu, Ramakanth published a patent.HPLC of Formula: 64987-16-2 The title of the patent was Preparation of arylcycloalkylpropionamides as glucokinase activators.. And the patent contained the following:
Title compounds [I; R1, R2 = H, halo, amino, hydroxyamino, NO2, cyano, sulfonamido, perfluoroalkyl, alkylthio, alkylsulfonyl, alkylsulfinyl, etc.; R3 = alkyl, cycloalkyl; R4 = CONHR40, (substituted) 5-6 membered heteroaryl; R40 = H, alkyl, alkenyl, hydroxyalkyl, haloalkyl, etc.], were prepared for treatment of type II diabetes. Thus, 3-cyclopentyl-2-(3,4-dichlorophenyl)propionic acid (preparation given), benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, and 2-aminothiazole in CH2Cl2 was treated with Et3N followed by 14 h stirring to give 3-cyclopentyl-2-(3,4-dichlorophenyl)-N-thiazol-2-ylpropionamide. I activated glucokinase in vitro with SC1.5≤30 μM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).HPLC of Formula: 64987-16-2
The Article related to arylcycloalkylpropionamide preparation glucokinase activator, cyclopentylphenylthiazolylpropionamide preparation glucokinase activator, diabetes type ii treatment arylcycloalkylpropionamide preparation and other aspects.HPLC of Formula: 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica