Kadam, Shuddhodan N.; Ambhore, Ajay N.; Kamble, Rahul D.; Wakhradkar, Mahesh G.; Gavhane, Priya D.; Gaikwad, Milind V.; Gunturu, Krishna Chaitanya; Dawane, Bhaskar S. published an article in 2021, the title of the article was Metal-free efficient thiolation of C(sp2) functionalization via in situ-generated NHTS for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole.Synthetic Route of 2010-06-2 And the article contains the following content:
A direct metal-free approach for the synthesis of novel sulfenylated 2-aminothiazole and imidazothiazole derivatives at room temperature was reported via an in situ-generated electrophilic thiolating agent. The present protocol provided mild and selective access for the insertion of C-S bond functionalization with good yield. The mechanistic path was justified via d. functional theory (DFT) calculations, which explored the role of the solvent in the reaction mechanism. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2
The Article related to phenyl aminothiazole heterocyclic thiol chemoselective thiolation dft, thio phenyl thiazolamine preparation, heterocyclic thiol phenyl imidazolthiazole chemoselective thiolation dft, hydroxyethyl thio phenyl methylimidazothiazole preparation and other aspects.Synthetic Route of 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica