Kasetti, Ashok Babu; Singhvi, Indrajeet; Nagasuri, Ravindra; Bhandare, Richie R.; Shaik, Afzal B. published an article in 2021, the title of the article was Thiazole-chalcone hybrids as prospective antitubercular and antiproliferative agents: design, synthesis, biological, molecular docking studies and in silico ADME evaluation.Computed Properties of 24295-03-2 And the article contains the following content:
In this paper design, a novel series of thiazole-chalcone hybrids I (R = 2-ClC6H4, 2-pyridyl, 2-thiazolyl, etc.) was synthesized and characterized and further evaluated for their antitubercular and antiproliferative activities by employing standard protocols. Among the twenty compounds, chalcones I (R = 2,4-(F)2C6H3, 2,4-(Cl)2C6H3), containing 2,4-difluorophenyl and 2,4-dichlorophenyl groups, showed potential antitubercular activity higher than the standard pyrazinamide (MIC = 25.34μM) with MICs of 2.43 and 4.41μM, resp. Chalcone I (R = 2-thiazolyl) containing heteroaryl 2-thiazolyl moiety exhibited promising antiproliferative activity against the prostate cancer cell line (DU-145), higher than the standard methotrexate (IC50 = 11 ± 1μM) with an IC50 value of 6.86 ± 1μM. Furthermore, cytotoxicity studies of these compounds against normal human liver cell lines (L02) revealed that the target mols. were comparatively less selective against L02. Addnl. computational studies using AutoDock predicted the key binding interactions responsible for the activity and the SwissADME tool computed the in silico drug likeliness properties. The lead compounds generated through this study, create a way for the optimization and development of novel drugs against tuberculosis infections and prostate cancer. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Computed Properties of 24295-03-2
The Article related to thiazole chalcone preparation diastereoselective antitubercular antitumor cytotoxic activity, pharmacodynamic study sar mol docking, autodock, swissadme, antiproliferative activity, antitubercular activity, chalcone, cytotoxic activity, thiazole and other aspects.Computed Properties of 24295-03-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica