On July 10, 2003, Lau, Jesper; Kodra, Janos Tibor; Guzel, Mustafa; Santosh, Kalpathy Chidambareswaran; Mjalli, Adnan M. M.; Andrews, Robert Carl; Polisetti, Dharma Rao published a patent.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of N-aryl amide derivatives as glucokinase (GK) activators. And the patent contained the following:
Amides and ureas, such as R3-X-A(R1)-L1-G-NR4R5 [A = N, C(R2); G = SO2, CO; L1 = bond or linking alkylene, etc.; X = bond, O, S, SO, SO2, N(R6), alkylene, etc.; R1, R3 = H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, etc.; R2 = H, alkyl; R1R2 = cycloalkyl or heterocyclic ring; R4 = H, alkyl; R5 = aryl, heteroaryl; R6 = H, alkyl], were prepared as GK activators for therapeutic use in the treatment of diseases or conditions where increasing glucokinase activity is beneficial, such as impaired glucose tolerance (IGT), Syndrome X, type 2 diabetes, type 1 diabetes, dyslipidemia, hyperlipidemia, hypertension, and obesity. Thus, amide I was prepared via formation of 2-(3,4-dichlorophenoxy)hexanoic acid in 55% yield by reacting Et 2-hydroxyhexanoate with 3,4-dichlorophenol using Ph3P and diisopropyl azodicarboxylate in THF followed by formation of I in 72% by an amidation reaction of 2-(3,4-dichlorophenoxy)hexanoic acid with 2-aminothiazole using TFFH and DIEA in THF. The prepared amides were assayed for human liver GK activation activity. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to heterocyclic amide preparation glucokinase activator, impaired glucose tolerance treatment heterocyclyl amide preparation, syndrome x treatment heterocyclyl amide preparation, diabetes treatment heterocyclyl amide preparation, dyslipidemia treatment heterocyclyl amide preparation, hyperlipidemia treatment heterocyclyl amide preparation and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica