On February 29, 2016, Lee, Nathanael J.; Song, Jung Min; Cho, Hyun-Ji; Sung, You Me; Lee, Taehee; Chung, Andrew; Hong, Sung-Ha; Cifelli, Jessica L.; Rubinshtein, Mark; Habib, Lila K.; Capule, Christina C.; Turner, R. Scott; Pak, Daniel T. S.; Yang, Jerry; Hoe, Hyang-Sook published an article.Product Details of 92-36-4 The title of the article was Hexa (ethylene glycol) derivative of benzothiazole aniline promotes dendritic spine formation through the RasGRF1-Ras dependent pathway. And the article contained the following:
The authors’ recent study demonstrated that an amyloid-β binding mol., BTA-EG4, increases dendritic spine number via Ras-mediated signaling. To potentially optimize the potency of the BTA compounds, the authors synthesized and evaluated an amyloid-β binding analog of BTA-EG4 with increased solubility in aqueous solution, BTA-EG6. The authors initially examined the effects of BTA-EG6 on dendritic spine formation and found that BTA-EG6-treated primary hippocampal neurons had significantly increased dendritic spine number compared to control treatment. In addition, BTA-EG6 significantly increased the surface level of AMPA receptors. Upon investigation into the mol. mechanism by which BTA-EG6 promotes dendritic spine formation, the authors found that BTA-EG6 may exert its effects on spinogenesis via RasGRF1-ERK signaling, with potential involvement of other spinogenesis-related proteins such as Cdc42 and CDK5. Taken together, the authors’ data suggest that BTA-EG6 boosts spine and synapse number, which may have a beneficial effect of enhancing neuronal and synaptic function in the normal healthy brain. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Product Details of 92-36-4
The Article related to bta eg6 preparation dendritic spine rasgrf1 erk signaling, hexaethylene glycol benzothiazole aniline derivative preparation dendritic spine, bta-eg6, dendritic spine, rap signaling, ras signaling and other aspects.Product Details of 92-36-4
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica