On July 17, 2008, Murray, Anthony; Lau, Jesper; Vedsoe, Per; Christiansen, Lise Brown published a patent.Application of 859522-19-3 The title of the patent was Preparation of ureidothiazolylthioalkanoates as glucokinase activators. And the patent contained the following:
Title compounds were prepared for treatment of diabetes, impaired glucose tolerance, obesity, hyperglycemia, syndrome X, and dyslipidemia (no data). Thus, [2-(2-chlorobenzyloxy)ethyl]-(trans-4-methylcyclohexyl)amine TFA salt (preparation given), Et 3-(2-aminothiazol-5-ylthio)-2,2-dimethylpropionate (preparation given), carbonyldiimidazole, and DMAP were stirred together in THF for 18 h; EtOH and aqueous NaOH were added followed by heating at 75° for 5 h to give 53% 3-[2-[3-[2-(2-chlorobenzyloxy)ethyl]-3-(trans-4-methylcyclohexyl)ureido]thiazol-5-ylthio]-2,2-dimethylpropionic acid. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Application of 859522-19-3
The Article related to ureidothiazolylthioalkanoate preparation glucokinase activator, diabetes obesity hyperglycemia syndrome x treatment thiazolylthioalkanoate ureido preparation, methylcyclohexylureidothiazolylsulfanylalkanoate preparation antidiabetic and other aspects.Application of 859522-19-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica