On February 15, 2007, Nunes, Joseph J.; Milne, Jill; Bemis, Jean; Xie, Roger; Vu, Chi B.; Ng, Pui Yee; Disch, Jeremy S.; Salzmann, Thomas; Armistead, David published a patent.Reference of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of oxazolopyridine derivatives as sirtuin modulators. And the patent contained the following:
The title compounds I [X7-X10 = N, CR20, CR22 (wherein R20 = H or solubilizing group; R22 = H, (un)substituted alkyl; one of X7-X10 = N and the others = CR20 or CR22; zero to one R20 is solubilizing group); R19 = 1,2-phenylene, pyridylene, 5-6 membered (hetero)arylene; R21 = (un)substituted NHCO, NHSO2, NHCONH, etc.; R31 = (un)substituted monocyclic or bicyclic (hetero)aryl; with provisos] and their analogs which are novel sirtuin-modulating compounds useful for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity, were prepared E.g., a 3-step synthesis of II, starting from 2-chloropyridin-3-amine and 3-nitrobenzoyl chloride, was given. Exemplified compounds I were tested for sirtuin modulating activity (data given). Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Reference of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to benzimidazole preparation sirtuin modulator antidiabetic antiobesity cardiovascular antiinflammatory antitumor, thiazolopyridine preparation sirtuin modulator antidiabetic antiobesity cardiovascular antiinflammatory antitumor, oxazolopyridine preparation sirtuin modulator antidiabetic antiobesity cardiovascular antiinflammatory antitumor and other aspects.Reference of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica