Day: October 26, 2022

Tomoshige, Shusuke; Nomura, Sayaka; Ohgane, Kenji; Hashimoto, Yuichi; Ishikawa, Minoru published an article in 2017, the title of the article was Discovery of Small Molecules that Induce the Degradation of Huntingtin.Computed Properties of 92-36-4 And the article contains the following content:

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. The authors designed two small hybrid mols. by linking a ligand for ubiquitin ligase (cellular inhibitor of apoptosis protein 1; cIAP1) with probes for mHtt aggregates, anticipating that these compounds would recruit cIAP1 to mHtt and induce selective degradation by the ubiquitin-proteasome system. The synthesized compounds reduced mHtt levels in HD patient fibroblasts and appear to be promising candidates for the development of a treatment for HD. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Computed Properties of 92-36-4

The Article related to huntington disease treatment huntingtin protein ciap1 hybrid mol preparation, bestatin hybrid preparation ciap1 mhtt interaction inhibitor huntington disease, huntington’s disease, drug design, medicinal chemistry, protein degradation, small-molecule protein degraders and other aspects.Computed Properties of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2021, El-Dash, Yara; Elzayat, Emad; Abdou, Amr M.; Hassan, Rasha A. published an article.Recommanded Product: 2010-06-2 The title of the article was Novel thienopyrimidine-aminothiazole hybrids: Design, synthesis, antimicrobial screening, anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis and VEGFR-2 inhibition. And the article contained the following:

A series of novel hybrid compounds of hexahydrobenzo[4,5]thieno[2,3-d]pyrimidine with aminothiazole scaffolds I (R = H, Br, O2N; R1 = H, Cl, Br; R2 = H, Me) were synthesized. The synthesized compounds were evaluated for their cytotoxic activity against the NCI-60 human tumor cell line panel. Compounds I (R = H; R1 = Cl; R2 = H) (II), I (R = Br; R1 = ; R2 = H) (III) and I (R = R1 = R2 = H) exhibited significant antiproliferative activities at 10-5 M dose. II exhibited excellent cytotoxic activity against CNS cancer cell lines including SNB-75 and SF-295 as well as renal cancer cell line CAKI-1 when compared with sorafenib as standard anticancer drug. In addition, III showed almost comparable anticancer activity to sorafenib against SNB-75 cell line and displayed moderate activity against SF-295 and CAKI-1 cell lines in comparison to sorafenib. II inhibited the vascular endothelial growth factor receptor 2 (VEGFR-2) with IC50 of 62.48 ± 3.7 nM and decreased both total VEGFR-2 and phosphorylated VEGFR-2 in treated SNB-75 cells suggesting its ability to down regulate cell proliferation, growth, and survival.. The flow cytometric anal. showed that II displayed its cytotoxic activity through the reduction of the cellular proliferation and induction of cell cycle arrest at the G2/M phase. II clearly boosted the level of the apoptotic caspase-3. All the synthesized compounds were also screened for their antibacterial and antifungal activity against four pathogenic strains of both Gram-pos. and Gram-neg. as well as Candida albicans. III exhibited antifungal activity against Candida albicans compared to nystatin as the standard antifungal compound The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 2010-06-2

The Article related to arylthiazolyl benzothienylpyrimidinylthioacetamide preparation antitumor activity vegfr2 inhibition, structure arylthiazolyl benzothienylpyrimidinylthioacetamide antitumor activity vegfr2 inhibition, lack antibacterial activity arylthiazolyl benzothienylpyrimidinylthioacetamide and other aspects.Recommanded Product: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Johnson, Jino; Yardily, A. published an article in 2020, the title of the article was Synthesis, spectral investigation, thermal, molecular modeling and bio-molecular docking studies of a thiazole derived chalcone and its metal complexes.Application of 24295-03-2 And the article contains the following content:

A thiazole-based chalconoid ligand (E)-3-(2-hydroxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one (HPTP) and its Co(II), Ni(II), Cu(II) and Zn(II) complexes have been synthesized. The synthesized compounds were characterized by elemental anal., molar conductance, UV-visible, FTIR, NMR, mass spectral techniques, magnetic susceptibility, powder XRD and SEM with EDAX. In addition, the structures were optimized with D. Functional Theory (DFT) computations. The Lewis base nature of HPTP, stability on coordination, charge transfer interactions, quantum chem. parameters and vibrational frequencies were analyzed. The mols. were docked with 5FX6 receptor as possible inhibitors of human rhinovirus (HRV) 3 C protease. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2

The Article related to transition metal hydroxyphenyl thiazolyl propenone schiff base complex preparation, optimized mol structure transition metal schiff base complex, nonlinear optical property transition metal schiff base complex, thermal stability magnetic property transition metal schiff base complex and other aspects.Application of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Choroba, Katarzyna; Maron, Anna; Switlicka, Anna; Szlapa-Kula, Agata; Siwy, Mariola; Grzelak, Justyna; Mackowski, Sebastian; Pedzinski, Tomasz; Schab-Balcerzak, Ewa; Machura, Barbara published an article in 2021, the title of the article was Carbazole effect on ground- and excited-state properties of rhenium(I) carbonyl complexes with extended terpy-like ligands.Application In Synthesis of 2-Acetylthiazole And the article contains the following content:

The ground- and excited-state properties of three [ReCl(CO)3(Ln-κ2N)] bearing 2,2′:6′,2”-terpyridine, 2,6-di(thiazol-2-yl)pyridine and 2,6-di(pyrazin-2-yl)pyridine functionalized with 9-carbazole attached to the central pyridine ring of the triimine core via phenylene linkage were investigated by spectroscopic and electrochem. methods and were simulated using d. functional theory (DFT) and time-dependent DFT. To get a deeper and broader understanding of structure-property relations, the designed Re(I) carbonyl complexes were compared with previously reported analogous systems – without any groups attached to the Ph ring and bearing pyrrolidine instead of 9-carbazole. Attachment of the N-carbazolyl substituent to the triimine core has less influence on the nature of the triplet excited state of [ReCl(CO)3(Ln-κ2N)] than the pyrrolidine group. Addnl., the impact of the ligand structural modifications on the light emission of the Re(I) complexes under external voltage was preliminarily examined with electroluminescence spectra of diodes containing the synthesized new mols. in an active layer. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application In Synthesis of 2-Acetylthiazole

The Article related to rhenium carbonyl carbazolylterpyridine carbazolylpyridinediylbisthiazol carbazolylpyridinediylbispyrazine complex preparation crystal structure, electrochem dft calculation rhenium carbonyl carbazolylterpyridine carbazolylpyridinediylbisthiazol carbazolylpyridinediylbispyrazine complex and other aspects.Application In Synthesis of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 30, 2022, Krause, Svenja; Asamoah, Eugenia Ayebea; Huc-Mathis, Delphine; Moulin, Gabrielle; Jakobi, Ralf; Rega, Barbara; Bonazzi, Catherine published an article.Quality Control of 2-Acetylthiazole The title of the article was Applicability of pea ingredients in baked products: Links between formulation, reactivity potential and physicochemical properties. And the article contained the following:

This study aimed to evaluate the applicability of purified pea ingredients (starch and protein isolate) by assessing their potential to form volatile compounds during the different steps of sponge cake development compared to pea flour and wheat flour. While pea flour was highly susceptible to lipid oxidation during batter beating, the combination of purified pea starch and pea protein yielded significantly fewer oxidation markers with known green-beany off-odors. This was due more to the inactivation of lipoxygenase during flour fractionation than to differences in batter structure. However, fractionated ingredients were highly prone to participating in the Maillard reaction and caramelization during baking, leading to a more complex mixture of pyrazines, Strecker aldehydes and furanic compounds with potential malty and roasted notes compared to cakes based on pea flour or wheat flour. These findings confirm that using purified pea fractions can create high-quality products with an attractive composition The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Quality Control of 2-Acetylthiazole

The Article related to pea starch flour cake aldehydes lipoxygenase lipid physicochem property, 1-hexanol, 1-octen-3-ol, 2,4-decadienal, 2,5-dimethylpyrazine, 2-ethyl-3,5-dimethylpyrazine, 2-methylpropanal, 3-methylbutanal, furan, furfural, hexanal, lipid oxidation, maillard reaction, pea protein, pea starch, structure and other aspects.Quality Control of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sagnou, Marina; Tzanopoulou, Stamatia; Raptopoulou, Catherine P.; Psycharis, Vassilis; Braband, Henrik; Alberto, Roger; Pirmettis, Ioannis C.; Papadopoulos, Minas; Pelecanou, Maria published an article in 2012, the title of the article was A Phenylbenzothiazole Conjugate with the Tricarbonyl fac-[M(I)(CO)3]+ (M = Re, 99Tc, 99mTc) Core for Imaging of β-Amyloid Plaques.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:

The 2-(4′-aminophenyl)-6-methylbenzothiazole that is known to display affinity and specificity toward the amyloid plaques of Alzheimer’s disease (AD) has been joined to the tricarbonyl [M(CO)3NNO] chelate (M = Re, 99Tc, and 99mTc) through a five-carbon linker chain to generate the neutral complex (1) (namely, Re-1 for M = Re; 99Tc-1 for M = 99Tc; and 99mTc-1 for M = 99mTc) with the aim of developing a single-photon emission computed tomog. (SPECT) radiodiagnostic agent for AD. Re-1 was characterized by spectroscopic methods and x-ray crystallog., whereas the detailed NMR spectroscopic anal. of 99Tc-1 demonstrated its structural similarity to Re-1. Complexes Re-1 and 99Tc-1 display selective binding affinity for amyloid plaques as evidenced by fluorescence spectroscopy, whereas the biodistribution data of 99mTc-1 characterized by relatively low brain uptake, fast clearance from brain and blood, and in vivo stability are considered encouraging for further elaboration on the structural features of 1 in the direction of increased brain uptake. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to radiolabeled benzothiazole chelate conjugate spect imaging amyloid alzheimers, crystal structure rhenium benzothiazolyl phenylaminocarbonylbutyl pyridinylmethyl aminoacetate tricarbonyl complex, mol structure rhenium benzothiazolyl phenylaminocarbonylbutyl pyridinylmethyl aminoacetate tricarbonyl complex and other aspects.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 5, 2012, Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki published a patent.SDS of cas: 19989-66-3 The title of the patent was Preparation of heterocyclic carbamate and carboxylic acid hydrazide compounds as p27Kip1 degradation inhibitors. And the patent contained the following:

There are provided novel heterocyclic compounds and salts thereof applicable in the selective inhibition of the degradation of cyclin-dependent kinase inhibitor protein (p27Kip1) for the prevention and/or treatment of cell proliferative diseases such as cancer, rheumatism, diabetes, obesity, endometriosis, prostatic hypertrophy (prostatic hyperplasia), and inflammation. The title compounds and salts thereof represented in formula [I; A represents an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and group A can have a substituent group; ring B represents a 5- to 8- membered monocyclic heterocyclic ring or a condensed ring containing this monocyclic heterocyclic ring, and ring B can have a substituent group; ring C represents an aromatic ring, and ring C can have a substituent group; L represents a linker having 3-5 atoms in the main chain selected from carbon atoms, nitrogen atoms, oxygen atoms, and sulfur atoms, and having at least one heteroatom selected from nitrogen atoms, oxygen atoms, and sulfur atoms, and linker L can have a substituent group; and n represents 0 or 1.] are prepared Thus, 1.11 g 2-(4-chloro-2-methoxyphenyl)-4-methylthiazole-5-carboxylic acid and 870 mg (1,2,3,4-Tetrahydrobenzo[d]pyrido[2,1-b]imidazol-7-yl)methanol were suspended in 50 mL toluene, successively treated with 475 mg Et3N and 1.18 g diphenylphosphoryl azide, and refluxed for 2 h to give, after workup and silica gel chromatog., 71% [2-(4-chloro-2-methoxyphenyl)-4-methylthiazol-5-yl]carbamic acid 1,2,3,4-tetrahydrobenzo[d]pyrido[2,1-b]imidazol-7-ylmethyl ester (II). II and 3-pyrazolylmethyl 5-benzimidazolylcarbamate derivative (III) in vitro induced apoptosis of human prostatic cancer cells (PC-3 cells) at 0.025 and 0.00625 μM, resp., and in vitro showed IC50 of 6.70 and 0.43 nM, resp., against PC-3 cells. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).SDS of cas: 19989-66-3

The Article related to p27kip1 degradation inhibitor heterocyclic carbamate preparation, heterocyclic carboxylic acid hydrazide preparation, cyclin dependent kinase inhibitor protein p27kip1 degradation inhibitor, cell proliferative disease prevention treatment, cancer rheumatism diabetes obesity endometriosis prevention treatment and other aspects.SDS of cas: 19989-66-3

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On August 31, 2021, Choroba, Katarzyna; Kotowicz, Sonia; Maron, Anna; Switlicka, Anna; Szlapa-Kula, Agata; Siwy, Mariola; Grzelak, Justyna; Sulowska, Karolina; Mackowski, Sebastian; Schab-Balcerzak, Ewa; Machura, Barbara published an article.Product Details of 24295-03-2 The title of the article was Ground- and excited-state properties of Re(I) carbonyl complexes – Effect of triimine ligand core and appended heteroaromatic groups. And the article contained the following:

In this work, a series of six rhenium(I) complexes bearing 2,2′:6′,2”-terpyridine (terpy), 2,6-di(thiazol-2-yl)pyridine (dtpy), and 2,6-di(pyrazin-2-yl)pyridine (dppy) with appended quinolin-2-yl and N-ethylcarbazol-3-yl groups were prepared and spectroscopically investigated to evaluate the photophys. consequences of both the trisheterocyclic core (terpy, dtpy and dppy) and the heterocyclic substituent. The [ReCl(CO)3(Ln-κ2N)] complexes are regarded as ideal candidates for getting structure-property relationships, while terpy-like framework represents an excellent structural backbone for structural modifications. The replacement of the peripheral pyridine rings of 2,2′:6′,2”-terpyridine by thiazoles and pyrazines resulted in a significant red-shift of the absorption and emission of [ReCl(CO)3(Ln-κ2N)] due to stabilization of the ligand-centered LUMO orbital. Both quinoline and N-ethylcarbazole are extended π-conjugation organic chromophores, but they differ in electron-donating abilities. The low-energy absorption band of Re(I) complexes with the triimine ligands bearing quinolin-2-yl group was contributed by the metal-to-ligand charge-transfer (MLCT) electronic transitions. The introduction of electron-donating N-ethylcarbazol-3-yl substituent into the triimine acceptor core resulted in the change of the character of the HOMO of Re(I) complexes and a significant increase of molar absorption coefficients of the long-wavelength absorption, which was assigned to a combination of 1MLCT and 1ILCT (intraligand charge-transfer) transitions. Regardless of the appended heteroaromatic group, the emitting excited state of Re(I) terpy-based complexes was demonstrated to have predominant 3MLCT character, as evidenced by comprehensive studies including static and time-resolved emission spectroscopy along with ultrafast transient absorption measurements. The diodes with Re(I) complexes dispersed molecularly in a PVK:PBD matrix were emissive and effects of the complex structure on color of emitted light and its intensity was pronounced. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Product Details of 24295-03-2

The Article related to quinolinyl carbazolyl terpyridine thiazolylpyridine pyrazinylpyridine rhenium carbonyl complex preparation, crystal mol structure quinolinyl carbazolyl terpyridine thiazolylpyridine pyrazinylpyridine rhenium, electrochem redox quinolinyl carbazolyl terpyridine thiazolylpyridine pyrazinylpyridine rhenium carbonyl and other aspects.Product Details of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 30, 2022, Keawkim, Kannika; Na Jom, Kriskamol published an article.COA of Formula: C5H5NOS The title of the article was Metabolomics and flavoromics analysis of chemical constituent changes during roasting of germinated Sacha inchi (Plukenetia volubilis L.). And the article contained the following:

This study examined the changes in metabolites together with the flavor profiles of germinated Sacha inchi seeds during roasting by using gas chromatog. The results indicated that roasting partially increased the browning index, amino acid levels, total phenolic content, and antioxidant capacity, but slightly decreased the levels of reducing sugars. Oxidized and rancid compounds were significantly decreased at a 180 °C roasting temperature Pyrazine, furan, and pyrrole were Maillard reaction products that were increased at 180 °C of roasting. Roasting at 145 °C for 45 min after germination for 4 days was determined to be the optimal conditions for roasting germinated Sacha inchi seeds, which reduced the off-flavor and burned taste. The roasted germinated Sacha inchi seed contains higher amino acids than raw seed, which could be used as an alternative source for food products and supplements. In addition, the roasted germinated seeds at 4 days were recommended for food applications. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).COA of Formula: C5H5NOS

The Article related to metabolome flavorome roasting browning germination plukenetia, bi, browning index, dvb/car/pdms, divinylbenzene/carboxen/polydimethylsiloxane, essential amino acids, fame, fatty acid methyl esters, ffa, free fatty acid, gc, gas chromatography, germination, hs-spme, autosampler headspace solid-phase microextraction and other aspects.COA of Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2022, Johnson, Jino; Yardily, Amose published an article.Recommanded Product: 2-Acetylthiazole The title of the article was Co(II), Ni(II), Cu(II), and Zn(II) metal complexes of chalcone: Synthesis, characterization, thermal, antimicrobial, photocatalytic degradation of dye and molecular modeling studies. And the article contained the following:

A thiazole-based chalcone ligand and its bidentate Co(II), Ni(II), Cu(II), and Zn(II) complexes of general formula [M(DMTP)2], (DMTP = (E)-3-(3,4-dimethoxyphenyl)-1-(thiazol-2-yl)prop-2-en-1-one) have been synthesized. The compounds were characterized by elemental analyses, molar conductance, fourier-transform IR (FTIR) spectra, 1H NMR, 13C NMR, mass, UV-Vis., magnetic susceptibility, and thermal and powder x-ray diffraction (XRD) techniques. Based on spectral data, tetrahedral geometry is assigned for Co(II), Ni(II), and Zn(II) complexes. Square planar geometry was observed for Cu(II) complex. Mol. geometries of the compounds were fully optimized with d. functional theory (DFT) computations. Addnl., the Lewis base character of DMTP, flexibility toward metal ions, structural stabilization on coordination, frontier MOs (FMO), quantum chem. parameters, and theor. vibrational frequencies were evaluated. The antibacterial and antifungal (in vitro and in silico) activities of the complexes were studied and compared with those of DMTP. Finally, the metal(II) complexes of DMTP were successfully used to enhance the removal of methylene blue (MB) dye from an aqueous solution The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Recommanded Product: 2-Acetylthiazole

The Article related to cobalt nickel copper zinc thiazolyl chalcone complex preparation antimicrobial, photocatalysis dye degradation cobalt nickel copper zinc thiazolyl chalcone, mol structure calculation cobalt nickel copper zinc thiazolyl chalcone, dimethoxyphenyl thiazolyl propenone cobalt nickel copper zinc preparation antimicrobial and other aspects.Recommanded Product: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica