Day: October 26, 2022

On November 2, 2020, Zhang, KaiYue; Li, Jing; Wang, KaiXuan; An, Xiaoying; Wang, LanZhi published an article.Formula: C5H5NOS The title of the article was Atom-economical Approaches to 1,5-Benzodiazepines Containing Indole Ring via Fe3O4@SiO2-PTSA-catalyzed Multi-component Domino Reactions. And the article contained the following:

Four novel atom-economical approaches for synthesis of 1,5-dihydrospiro[benzo[b][1,4]diazepine-2,3′-indole] compounds, e.g., I via three-component or four-component domino reactions was developed in presence of a catalytic amount of magnetic nanoparticles (Fe3O4@SiO2-PTSA) in ethanol, which provided an efficient one-pot synthesis of 1,5-benzodiazepines with multi-ring system and functional groups containing indole, aryl, ester, acyl and alkyl groups in excellent yields. In a one-pot operation, two new nitrogen heterocycle (indole and diazepine) rings and four new chem. bonds (one C-C, two C-N and one C=C) were constructed by series of domino reactions. Furthermore, plausible catalytic synthesis reaction mechanisms had been proposed. The advantages of these methods were green reaction process, recyclable magnetic catalyst, mild reaction conditions, short reaction time and high yields of products. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS

The Article related to iron oxide silica supported toluenesulfonic acid nanoparticle catalyst preparation, dihydrospiro benzodiazepine indole chemoselective regioselective green preparation atom economy, phenylenediamine ketone indole multicomponent domino magnetic nanoparticle catalyst, ketone phenylenediamine indole dmf dimethylacetal multicomponent domino magnetic nanocatalyst and other aspects.Formula: C5H5NOS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 16, 2013, Harriman, Geraldine C.; Masse, Craig E.; Harwood, James; Bhat, Sathesh; Greenwood, Jeremy Robert published a patent.Application of 64987-16-2 The title of the patent was Preparation of thienopyrimidinedione derivatives as ACC inhibitors. And the patent contained the following:

The present invention provides compounds, specifically thienopyrimidine derivatives I [X = O, S, or NR; R1 = H, (un)substituted alkyl; R2 = halo, R, OR, etc.; or R1 and R2 are taken together to form (un)substituted 4-7 membered partially unsaturated carbocyclo-, or heterocyclo-, benzo-, or 5-6 membered heteroaryl- fused ring; R = H, (un)substituted alkyl, Ph, etc.; L1, L2 = a bond, alkylene, cyclobutylenyl, etc.; R3 = H, halo, CN, etc.; R4 = H, (un)substituted 3-8 membered monocyclic saturated or partially unsaturated carbocyclic ring, etc.; with the provisos], useful as inhibitors of Acetyl CoA Carboxylase (ACC), pharmaceutical compositions thereof, and methods of using the same for treating ACC-mediated disorders such as obesity, dyslipidemia, hyperlipidemia, fungal, parasitic or bacterial infections in a subject. The invention further provides a method of inhibiting ACC in a plant comprising contacting the plant with the inhibitor compound I. Over three-hundred compounds I were prepared E.g., a multi-step synthesis of (2S)-II, starting from Et 3-oxobutanoate and Et 2-cyanoacetate, was described. Exemplified compounds I were tested in in vitro ACC1 and ACC2 inhibition assays (data given). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2

The Article related to thienopyrimidinedione preparation acetyl coa carboxylase acc inhibitor metabolic disorder, antiobesity fungicide antiparasitic antibacterial thienopyrimidinedione preparation acc inhibitor, dyslipidemia hyperiipidemia treatment thienopyrimidinedione preparation acc inhibitor, thienopyrimidine preparation acetyl coa carboxylase acc inhibitor metabolic disorder and other aspects.Application of 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2004, Moloney, Gerard P.; Garavelas, Agatha; Martin, Graeme R.; Maxwell, Miles; Glen, Robert C. published an article.Category: thiazole The title of the article was Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor. And the article contained the following:

The synthesis and vascular 5-HT1B receptor activity of a novel series of substituted 3-amido phenylpiperazine and 4-(4-methyl-1-piperazinyl)-1-benzo[b]thiophene derivatives is described. Modifications to the amido linked sidechains of the 3-amidophenyl piperazine derivatives and to the 2-side-chain of the 1-benzo[b]thiophene derivatives have been explored. Several compounds were identified which exhibited affinity at the vascular 5-HT1B receptor of pKB > 7.0. From the 3-amidophenyl-piperazine series, N-[5-(4-chlorophenyl)-2-thiazolyl]-3-(4-methyl-1-piperazinyl)benzamide (I) and from the benzo[b]thiophene-4-piperazine series N-(2-ethylphenyl)-4-(4-methyl-1-piperazinyl)benzo[b]thiophene-2-carboxamide (II) were identified as a highly potent, silent (as judged by the inability of angiotensin II to unmask 5-HT1B receptor mediated agonist activity in the rabbit femoral artery) and competitive vascular 5-HT1B receptor antagonist. The affinity of compounds from these two series of compounds for the vascular 5-HT1B receptor is discussed as well as a proposed mode of binding to the receptor pharmacophore. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Category: thiazole

The Article related to 5-ht antagonists (type 5-ht1b), 5-ht1b receptors role: bsu (biological study, unclassified), biol (biological study) (antagonists), molecular modeling, pharmacophores, structure-activity relationship, serotoninergic antagonist and other aspects.Category: thiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica