On December 15, 2021, Rizk, Mariam G.; Emara, Adel A. A.; Mahmoud, Nelly H. published an article.Name: 4-Phenylthiazol-2-amine The title of the article was Spectroscopic studies, DFT calculations, thermal analysis, anti-cancer evaluation of new metal complexes of 2-hydroxy-N-(4-phenylthiazol-2-yl)benzamide. And the article contained the following:
2-Hydroxy-N-(4-phenylthiazol-2-yl)benzamide was reacted with Cr(III), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Ag(I) metal ions to synthesize the corresponding coordination compounds 2-Hydroxy-N-(4-phenylthiazol-2-yl)benzamide was rearranged to 2-hydroxy-N-(4-phenyl-1,3-thiazole-2-yl)carboxymidic acid (HL) due to the keto-enol tautomeric forms, where the enol form is more dominant. The structures of the HL ligand and the newly synthesized coordination compounds were characterized by elemental anal., IR, UV-Visible, 1H NMR, ESR and mass spectral data, in addition to TGA and magnetic and molar conductance measurements. The ligand behaves as a monobasic bidentate ON sites, where the bidentate binding of the ligand involving the phenolic oxygen and azomethine nitrogen. The binding modes of the coordination compounds were further confirmed using Gaussian 09 software. The complexes of Co(II), Cu(II), Zn(II), and Ag(I) were tested in vitro against human colon carcinoma cells (HCT-116). The IC50 values showed dramatic toxicity results for cobalt(II), copper(II) and zinc(II) complexes vs. human colon carcinoma (HCT-116) cell line, compared to African green monkey kidney (VERO) normal cell line. According to the results of the IC50 values obtained for Co(II), Cu(II), Zn(II), and Ag(I) 1.5, 1.0, 1.8 and 7.3μg/mL, resp., compared to the reference drug (2.49μg/mL), Co(II), Cu(II), Zn(II) compounds are considered strong antitumor agent while Ag(I) compound can be considered as a weak one. For both antifungal and antibacterial activities, HL and all its coordination compounds were evaluated. HL ligand has only high activity against B. subtilis and C. albicans while Co(II) and Zn(II) compounds have the highest activity against S. aureus, P. aeruginisa, B. subtilis and E. coli. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Name: 4-Phenylthiazol-2-amine
The Article related to transition metal hydroxythiazolylbenzamide complex preparation antitumor antimicrobial dft fluorescence, thermal decomposition kinetics transition metal hydroxythiazolylbenzamide complex antitumor human and other aspects.Name: 4-Phenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica