On August 31, 2021, Sankar, P. Siva; Babu, K. Narendra; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram published an article.Product Details of 2010-06-2 The title of the article was Molecular properties prediction, synthesis, and antimicrobial activity of bis(azolyl)sulfonamidoacetamides. And the article contained the following:
A library of bis(azolyl)sulfonamidoacetamides I [X = NH, O, S; Y = NH, O; Ar = Ph, 4-methylphenyl, 4-chlorophenyl] was prepared by the reaction of azolylsulfonylamines with azolylchloroacetamides in the presence of pyridine/4-(dimethylamino)pyridine under ultrasonication. The reaction proceeded well with DMAP, resulted in a higher yield of the products. The antimicrobial activity of the compounds I indicated that I [X = S; Y = NH; Ar = phenyl], I [X = S; Y = NH; Ar = 4-chlorophenyl], and I [X = NH; Y = NH; Ar = 4-chlorophenyl] exhibited a low minimal inhibitory concentration (MIC) against Bacillus subtilis, equal to the standard drug, chloramphenicol. Compounds I [X = S; Y = NH; Ar = 4-chlorophenyl] and I [X = NH; Y = NH; Ar = 4-chlorophenyl] also showed low MICs against Aspergillus niger, equal to the standard drug, ketoconazole. The mol. properties of the synthesized mols. I were studied to identify drug-likeness properties of the target compounds On the basis of mol. properties prediction, I [X = O; Y = O; Ar = phenyl], I [X = O; Y = O; Ar = 4-methylphenyl], I [X = O; Y = NH; Ar = 4-methylphenyl], I [X = O; Y = NH; Ar = 4-chlorophenyl], I [X = S; Y = O; Ar = Ph, 4-methylphenyl, 4-chlorophenyl], I [X = S; Y = NH; Ar = 4-methylphenyl], I [X = S; Y = NH; Ar = 4-chlorophenyl], and I [X = NH; Y = O; Ar = Ph, 4-methylphenyl, 4-chlorophenyl] can be treated as drug candidates. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Product Details of 2010-06-2
The Article related to bisazolyl sulfonamidoacetamide preparation antibacterial antifungal sar ultrasound, antibacterial activity, antifungal activity, bis(azolyl)sulfonamidoacetamides, molecular properties, ultrasonication and other aspects.Product Details of 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica