On October 1, 2019, Shaaban, Saad; Ashmawy, Abeer M.; Negm, Amr; Wessjohann, Ludger A. published an article.Reference of 4-Phenylthiazol-2-amine The title of the article was Synthesis and biochemical studies of novel organic selenides with increased selectivity for hepatocellular carcinoma and breast adenocarcinoma. And the article contained the following:
Nineteen organoselenides, e.g., 2-((4-aminophenyl)selanyl)-3-methylnaphthalene-1,4-dione were synthesized and tested for their intrinsic cytotoxicity in hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines and their corresponding selective cytotoxicity (SI) was estimated using normal lung fibroblast (WI-38) cells. Most of the organic selenides exhibited good anticancer activity, and this was more pronounced in HepG2 cells. Interestingly, the 2-((4-aminophenyl)selanyl)-3-methylnaphthalene-1,4-dione, Me 3-((2-amino-4-methylthiazol-5-yl)selanyl)propanoate, and 4-((4-selenocyanatophenyl)diazenyl)phenol organic selenides demonstrated promising SI (up to 76). Furthermore, 4-((2,2-diethoxyethyl)selanyl)aniline, 2-((4-aminophenyl)selanyl)-3-methylnaphthalene-1,4-dione, and azo-based 4-((4-selenocyanatophenyl)diazenyl)phenol and 2-amino-5-((4-selenocyanatophenyl)diazenyl)benzoic acid organic selenides were able to down-regulate the expression of Bcl-2 and up-regulate the expression levels of IL-2, IL-6 and CD40 in HepG2 cells compared to untreated cells. Moreover, most of the synthesized candidates manifested good free radical-scavenging and GPx-like activities comparable to vitamin C and ebselen. The obtained results suggested that some of the presented organoselenium candidates have promising anti-HepG2 and antioxidant activities. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Reference of 4-Phenylthiazol-2-amine
The Article related to organoselenide preparation anticancer antioxidant activity, antioxidant, azo coupling, breast adenocarcinoma, diselenides, hepatocellular carcinoma, michael-type reaction, selenides, selenocyanates and other aspects.Reference of 4-Phenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica