Althagafi, Ismail; El-Metwaly, Nashwa M.; Farghaly, Thoraya published an article in 2019, the title of the article was Characterization of new Pt(IV)-thiazole complexes: Analytical, spectral, molecular modeling and molecular docking studies and applications in two opposing pathways.Application of 2010-06-2 And the article contains the following content:
New thiazole derivatives were synthesized and fully characterized, then coordinated with PtCl4 salt. Also, the newly synthesized Pt(IV) complexes were studied anal. (elemental and thermogravimetric analyses), spectrally (IR, UV-visible, mass, 1H NMR, 13C NMR, x-ray diffraction) as well as theor. (kinetics, modeling and docking). The data extracted led to the establishment of the best chem. and structural forms. Octahedral geometry was the only formula proposed for all complexes, which is favorable for d6 systems. The mol. ion peaks from mass spectral anal. coincide with all anal. data, confirming the mol. formula proposed. XRD and SEM allowed discrimination of features between crystalline particles and other amorphous morphol. By applying Gaussian09 as well as HyperChem 8.2 programs, the best structural forms were obtained, as well as computed significant parameters. Computed parameters such as softness, hardness, surface area and reactivity led the authors towards application in two opposing pathways: tumor inhibition and oxidation activation. The catalytic oxidation for CO was conducted over PtO2, which was yielded from calcination of the most reactive complex. The success of catalytic role for synthesized PtO2 was due to its particulate size and surface morphol., which were estimated from XRD patterns and SEM images, resp. The antitumor activity was tested vs. HCT-116 and HepG-2 cell lines. Mild toxicity was recorded for two of the derivatives and their corresponding complexes. This degree of toxicity is more favorable in most cases, due to exclusion of serious side effects, which is coherently attached with known antitumor drugs. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2
The Article related to aminothiazole derivative platinum complexation electronic structure mol docking, platinum aminothiazole derivative preparation antitumor activity thermolysis kinetics qsar and other aspects.Application of 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica