On February 4, 2021, Anderson, David Randolph; Jacobsen, Eric Jon; Blinn, James Robert; Hockerman, Susan Landis; Mukherjee, Paramita; Changelian, Paul published a patent.Synthetic Route of 1092942-42-1 The title of the patent was Substituted sulfonamide pyrrolopyridines as JAK inhibitors and their preparation. And the patent contained the following:
The invention relates to sulfonamide pyrrolopyridine compounds of formula I and compositions useful in the treatment of JAK-mediated conditions. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided. Exemplary indications treated by inhibition of JAK kinase activity include, but are not limited to, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, irritable bowel syndrome, and Celiac disease. Compounds of formula I wherein R1 is CN, CO2C1-6 alkyl and (un)substituted 5- to 10-membered heteroaromatic ring; R2 and R3 are independently H, (un)substituted C1-4 alkyl and (un)substituted C0-2 alkyl-C3-6 cycloalkyl; R4 is (un)substituted C1-6 alkyl, (un)substituted C0-4 alkyl-C3-6 cycloalkyl, (un)substituted C2-5 alkyl-COC0-4 alkyl-C3-6 cycloalkyl, etc.; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for the JAK inhibitory activity (data given). The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Synthetic Route of 1092942-42-1
The Article related to pyrrolopyridine sulfonamide preparation jak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 1092942-42-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica