Bierer, Donald E. et al. published their patent in 1999 |CAS: 64987-16-2

The Article related to piperazine preparation hypoglycemic antidiabetic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

On June 24, 1999, Bierer, Donald E.; Moinet, Gerard G.; Botton, Gerard; Dubenko, Larisa; Patereau, Gerard; Doare, Liliane; Kergoat, Micheline; Mesangeau, Didier; Lu, Qing published a patent.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Piperazine derivatives useful as hypoglycemic agents. And the patent contained the following:

A variety of piperazine derivatives useful as antihyperglycemic agents, pharmaceutical compositions comprising them, and methods for their use are described. For example, compounds I are disclosed [wherein Ar = certain mono- and polycyclic aryl and heteroaryl groups; R1, R2, R3 = H, alkyl, alkoxyalkyl, cycloalkyl, aryl, heteroaryl, arylalkoxy, aryloxy, etc.; or ArNR1 = indolinyl, quinolyl, indolyl, or tetrahydroquinolyl; R4, R5, R6 = H, cycloalkyl, alkyl, alkoxy, halo, CF3, aryl, aryloxy, cyano, CO2H, OH, NH2, NO2, etc.]. The compounds are useful for the treatment of insulin-dependent diabetes mellitus (IDDM or Type I) and non-insulin dependent diabetes mellitus (NIDDM or Type II). For instance, coupling of 4-chloro-2-(chloroacetamido)benzoic acid with 1-(2-methoxyphenyl)piperazine in DMF in the presence of Et3N gave title compound II. Compounds I gave significant reductions of blood glucose in a variety of animal diabetes models. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to piperazine preparation hypoglycemic antidiabetic, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica