On November 15, 2001, Corbett, Wendy Lea; Haynes, Nancy-Ellen; Sarabu, Ramakanth published a patent.Formula: C6H8N2O2S The title of the patent was Preparation of substituted phenylacetamides and their use as glucokinase activators. And the patent contained the following:
The title compounds 4-R[(CH2)yX]zC6H4CH(CH2R1)CONHR2 [X = O, SO2; R is a ring; R1 is cycloalkyl; y and z are 0 or 1; R2 is -CONHR3 or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom], active as glucokinase activators to increase insulin secretion, were prepared E.g., 2-biphenyl-4-yl-3-cyclopentyl-N-thiazol-2-ylpropionamide was prepared by reaction of 4-biphenylacetic acid with iodomethylcyclopentane, followed by treatment with 2-aminothiazole. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S
The Article related to phenylacetamide preparation glucokinase activator, acetamide phenyl preparation glucokinase activator, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C6H8N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica