On November 5, 2020, Jacobsen, Eric Jon; Anderson, David Randolph; Blinn, James Robert; Mukherjee, Paramita; Changelian, Paul; Xu, Canxin published a patent.Recommanded Product: 1092942-42-1 The title of the patent was Substituted pyrrolopyridines as JAK inhibitors and their preparation and their preparation. And the patent contained the following:
The invention relates to pyrrolopyridine compounds having the structures of formula I, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis. Compounds of formula I wherein R1 is CN and (un)substituted heteroaryl; R2 is H, (un)substituted C1-4 alkyl, (un)substituted C3-6 cycloalkyl and (un)substituted C1-2 alkyl-C3-6 cycloalkyl; Q is absent, CH2 and CH2CH2; R3 is H, halo, (un)substituted C1-4 alkyl, (un)substituted C3-6 cycloalkyl, etc.; two R3 groups may be taken together to form a spirocyclic or bicyclic ring system; R4 is COR6, CH2R5, COC1-5 alkyl and COC3-6 cycloalkyl; R6 is C1-5 alkyl, C3-6 cycloalkyl, aryl, aryloxy, etc.; and derivatives thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their JAK inhibitory activity (data given). The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Recommanded Product: 1092942-42-1
The Article related to pyrrolopyridine preparation jak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 1092942-42-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica