On July 9, 2020, Maccallini, Cristina; Arias, Fabio; Gallorini, Marialucia; Amoia, Pasquale; Ammazzalorso, Alessandra; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Cataldi, Amelia; Camacho, Maria Encarnacion; Amoroso, Rosa published an article.SDS of cas: 2010-06-2 The title of the article was Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation. And the article contained the following:
In the present work a set of aryl and amido-aryl acetamidine derivatives were synthesized to obtain new potent and selective inducible Nitric Oxide Synthase inhibitors with improved physicochem. parameters with respect to the previously published mols. Compound I emerged as the most promising inhibitor, and was evaluated on C6 rat glioma cell line, showing antiproliferative effects and high selectivity over astrocytes. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2
The Article related to aryl acetamidine hydrobromide preparation nitric oxide synthase inhibition sar, amidoaryl acetamidine preparation antitumor nitric oxide synthase inhibition sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica