On August 31, 2022, Nasli Esfahani, Anita; Iraji, Aida; Alamir, Amir; Moradi, Shahram; Asgari, Mohammad Sadegh; Hosseini, Samanesadat; Mojtabavi, Somayeh; Nasli-Esfahani, Ensieh; Faramarzi, Mohammad Ali; Bandarian, Fatemeh; Larijani, Bagher; Hamedifar, Haleh; Hajimiri, Mir Hamed; Mahdavi, Mohammad published an article.Application of 2010-06-2 The title of the article was Design and synthesis of phenoxymethybenzoimidazole incorporating different aryl thiazole-triazole acetamide derivatives as α-glycosidase inhibitors. And the article contained the following:
A novel series of phenoxymethybenzimidazole derivatives I (R1 = H, 4-F, 4-Br, 4-CH3, 3-OCH3, 4-OCH3; R2 = H, CH3; R3 = H, OCH3) were rationally designed, synthesized, and evaluated for their α-glycosidase inhibitory activity. All tested compounds displayed promising α-glycosidase inhibitory potential with IC50 values in the range of 6.31 to 49.89μM compared to standard drug acarbose (IC50 = 750.0 ± 10.0μM). Enzyme kinetic studies on I (R1 = 4-Br, R2 = R3 = H; R1 = R2 = H, R3 = OCH3; R1 = 4-CH3, R2 = CH3, R3 = H) as the most potent compounds revealed that these compounds were uncompetitive inhibitors into α-glycosidase. Docking studies confirmed the important role of benzimidazole and triazole rings of the synthesized compounds I to fit properly into the α-glycosidase active site. This study showed that this scaffold can be considered as a highly potent α-glycosidase inhibitor. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2
The Article related to phenoxymethybenzimidazole preparation glycosidase inhibitor docking study sar, benzimidazole, enzyme inhibition, synthesis, triazole-acetamide, α-glycosidase, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica