Day: October 28, 2022

On December 18, 2008, Gaufreteau, Delphine; Nettekoven, Matthias; Plancher, Jean-Marc; Roche, Olivier; Schmitt, Sebastien; Takahashi, Tadakatsu published a patent.Application In Synthesis of 2-Bromo-N-methylthiazole-4-carboxamide The title of the patent was Preparation of cyclohexyl piperazinyl methanones as modulators of histamine H3 receptors.. And the patent contained the following:

Title compounds [I; R1 = alkyl, cycloalkyl; R2 = (substituted) heteroarylphenyl, heterocyclylphenyl, heteroaryl], were prepared Thus, cis-4-hydroxycyclohexanecarboxylic acid, 1-cyclobutylpiperazine dihydrochloride, TBTU, and diisopropylethylamine were stirred together for 8 h at room temperature in DMF to give 76% amide, which was stirred with 4-(1,2,4-triazol-1-yl)phenol, Ph3P, and di-tert-Bu azodicarboxylate in THF for 72 h to give 11% trans-(4-cyclobutylpiperazin-1-yl)-[4-[4-[1,2,4]triazol-1-ylphenoxy]cyclohexyl]methanone. The latter showed a Ki value of 6.5 nM in an H3 binding assay. The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Application In Synthesis of 2-Bromo-N-methylthiazole-4-carboxamide

The Article related to cyclohexyl piperazinyl methanone preparation histamine h3 receptor modulator, obesity diabetes treatment cyclohexylcarbonylpiperazine preparation antihistamine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application In Synthesis of 2-Bromo-N-methylthiazole-4-carboxamide

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On January 31, 2020, Shahrivari, Somaye; Kowsari, Elaheh; Shockravi, Abbas; Ehsani, Ali published an article.Safety of 4-Phenylthiazol-2-amine The title of the article was Synthesis and electrochemical capacitor characterization of new copolyimides containing thiazole ring and their composites with conductive polymer. And the article contained the following:

Abstract: In this research work, copolyimides (PIa,b) were synthesized by chem. routs. We used perylene-3,4,9,10-tetracarboxylic dianhydride and synthesized diamines (DAa,b) containing thiazole ring as monomers to obtain PIa,b which were characterized by 1HNMR and FTIR spectroscopies. We prepared POAP/PIa and POAP/PIb by depositing poly ortho amino phenol (POAP) as conductive polymer on the surface of PIa,b via in situ electropolymerization To evaluate the effect of the PIa,b in terms of the electrochem. performance of composites, we used galvanostatic charge/discharge, cyclic voltammetry, and electrochem. impedance spectroscopy. The specific capacitance of 207.2 and 322.4 F/g are obtained for POAP/PIa and POAP/PIb, resp. All these evidences prove that POAP/PI composites have long cycle life as well as high specific capacitance, which are indicative for being a good candidate in terms of application in supercapacitors. Graphic abstract: [Figure not available: see fulltext.]. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Safety of 4-Phenylthiazol-2-amine

The Article related to supercapacitor electrode polyimide thiazolamine ptcda, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Safety of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 1, 2020, Zhang, Wenjuan; Wei, Zhao; Huang, Guozhi; Xie, Fei; Zheng, Zhibing; Li, Song published an article.Synthetic Route of 2010-06-2 The title of the article was Study of triaryl-based sulfamic acid derivatives as HPTPβ inhibitors. And the article contained the following:

A series of novel triaryl-based sulfamic acid analogs I [R = H, 3-FC6H4CH2C(O), 4-MeOC6H4SO2, etc.; Ar = Ph, 4-phenylthiazol-2-yl, 4-(2-thienyl)thiazol-2-yl] was designed, synthesized and evaluated as inhibitors of human protein tyrosine phosphatase beta (HPTPβ). A novel, easy and efficient synthetic method was developed for target compounds I, and the activity determination results showed that most of compounds were good HPTPβ inhibitors. Interestingly, the compounds I [R = 1-tert-butoxycarbonylpiperidine-4-carbonyl, Ar = Ph; R = H, Ar = 4-(2-thienyl)thiazol-2-yl] with simple structure not only showed potent inhibitory activity on HPTPβ but also had good inhibitory selectivity over other PTPs (PTP1B, SHP2, LAR and TC-PTP). The mol. docking simulation of compounds with the protein HPTPβ helped to understand the structure-activity relationship and clarified some confusing assay results. This research provided references for further drug design of HPTPβ and other PTPs inhibitors. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Synthetic Route of 2010-06-2

The Article related to triaryl based sulfamic acid preparation sar docking hptpbeta inhibitor, docking simulation, drug design, hptpβ inhibitor, synthesis, triaryl-based derivatives, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Sulfenic, Sulfinic, and Sulfonic Acids and Derivatives and other aspects.Synthetic Route of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 22, 2004, Shi, Qian; Wang, Hui-kang; Oyama, Masayoshi; Vance, John Robert; Chen, Ming S. published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of podophyllotoxin derivatives as anticancer compounds. And the patent contained the following:

Podophyllotoxin derivatives, such as I [R1, R2, R3, R7 = H, alkyl; R4, R6 = alkyl; R5 = H, P(O)(ORa)2; Ra = H, alkyl; T = H; XT = :N; X = bond, O, S, NRb; Rb = H, alkyl; Y = 5-membered heteroaryl or heterocyclyl, optionally substituted with one or more halogen, alkyl, cyclyl, aryl, heteroaryl, heterocyclyl, etc.], were prepared for their therapeutic use as anticancer agents. Thus, podophyllotoxin derivative II was prepared via a multistep synthetic sequence starting from 4′-demethyl-4β-bromo-4-desoxypodophyllotoxin (prepared from podophyllotoxin), 2-aminothiazole-4-acetic acid and (trimethylsilyl)diazomethane. II showed unexpectedly high levels of cellular protein-linked DNA breaks (PLDB) induction in KB cells when tested at 5μg/mL. This invention also features a method for treating cancer. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to podophyllotoxin derivative preparation anticancer, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Koohgard, Mehdi; Hosseinpour, Zeinab; Sarvestani, Abdollah Masoudi; Hosseini-Sarvari, Mona published an article in 2020, the title of the article was ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light.Electric Literature of 2010-06-2 And the article contains the following content:

An ARS-TiO2 photocatalyst has been prepared by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazoles I (R = H, 2-Cl, 4-Ph, etc.), phenols R1OH (R1 = Ph, 3-ethylphenyl, 2-formylphenyl, etc.), anilines R2C6H4N(R3)(R4) (R2 = 2-Me, 3-Cl, 3-OMe, etc.; R3 = H, Me, Et, Ph; R4 = H, Me, Et), indoles II (R5 = H, Me; R6 = H, Me; R7 = H, 5-MeO, 6-methoxycarbonyl, 5-Br, 5-Me) and pyrroles such as 1H-pyrrole and 1-methyl-1H-pyrrole) were treated with the ammonium thiocyanate at room temperature Thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives III (R8 = Me, I, prop-1-en-2-yl, etc.) under visible light are presented. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to thiocyanation cyclization visible light ars photocatalyst regioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2021, Godugu, Kumar; Shaik, Sultana; Mohinuddin Pinjari, Mohammad Khaja; Gundala, Trivikram Reddy; Chellappa Subramanyam, Dwaraka Viswanath; Loka, Subramanyam Sarma; Divi, Haranath; Vemula, Venkatramu; Reddy Nallagondu, Chinna Gangi published an article.COA of Formula: C9H8N2S The title of the article was Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices. And the article contained the following:

A facile and more efficient solvent-free mechanochem. synthetic route has been developed for the synthesis of a series of solid state white light emissive thiazole-based donor-acceptor (D-A) type fluorophores, 2-(3-pyridyl)/2-aminothiazoles from ω-bromomethylketones and pyridine-3-carbothioamide/thiourea in the presence of silica-supported HClO4 as a reusable solid Bronsted acid catalyst at RT. The photophys. and electrochem. properties of these compounds have been derived. Most of the studied D-A type solid thiazole-based fluorophores emitted white light and it can be tuned from warm – ideal – cold white light by introduction of a variety of substituents at 4th position of 2-(3-pyridyl)/2-aminothiazoles. Further, HOMO and LUMO energy levels of the titled compounds are found to be in the range -5.52 eV to -5.72 eV and -1.84 eV to -2.45 eV, resp. The lifetimes of these levels of thiazole-based fluorophores have been determined through luminescence decay curves and are found to be in the range of 7.7-11μs. The photophys. and electrochem. properties of the synthesized thiazole-based fluorophores indicate that the compounds could be promising materials for white organic light emitting devices. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to solid state thiazole fluorophore organic light emitting device, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Structure Correlation With Physical Properties and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2019, Gong, Weinan; Xu, Bin; Yin, Xiaoshuang; Liu, Ying; Chen, Yun; Yang, Wenzhong published an article.Computed Properties of 2010-06-2 The title of the article was Halogen-substituted thiazole derivatives as corrosion inhibitors for mild steel in 0.5 M sulfuric acid at high temperature. And the article contained the following:

The inhibitory effects of three halogen-substituted thiazole derivatives named 2-amino-4-(4-fluorophenyl)-thiazole (FPT), 2-amino-4-(4-chlorophenyl)-thiazole (CPT) and 2-amino-(4-bromophenyl)-thiazole (BPT) on mild steel corrosion were investigated in 0.5 M H2SO4 from 30°C to 60°C. Electrochem. measurements demonstrated that these thiazoles can effectively inhibit the corrosion of mild steel in 0.5 M H2SO4 solution at 30°C. With the increase of temperature, the inhibition efficiency (η) of FPT at 60°C reduced to 22.62% while those of CPT and BPT under the same temperature were nearly unchanged, which were as high as 95.16% and 95.45%, resp. The adsorptions of three thiazoles on the surface of mild steel were all found to adhere to Langmuir adsorption isotherm at 30°C while only CPT and BPT obeyed at 60°C. Quantum calculations results indicated that CPT and BPT had the better adsorption ability on mild steel than FPT. Mol. dynamic stimulations were taken out to investigate the adsorption configurations of three thiazoles on the surface of Fe (0 0 1) at 30°C and 60°C, and the results implied that the binding energy of protonated BPT and CPT were nearly unchanged at studied temperatures while that of protonated FPT apparently became lower at 60°C. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to halogen substituted thiazole derivative corrosion inhibitor mild steel temperature, Ferrous Metals and Alloys: Corrosion (If The Primary Interest Is In The Metal), Erosion, Cavitation, Tribology, and Oxidation and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 27, 2003, Boyd, Scott; Caulkett, Peter William Rodney; Hargreaves, Rodney Brian; Bowker, Suzanne Saxon; James, Roger; Johnstone, Craig; Jones, Clifford David; McKerrecher, Darren; Block, Michael Howard published a patent.HPLC of Formula: 64987-16-2 The title of the patent was Preparation of benzamides affecting glucokinase for combined treatment or prevention of type 2 diabetes and obesity. And the patent contained the following:

The invention relates to the use of benzamides (shown as I; variables defined below; e.g. 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole) or a salt, solvate or prodrug thereof, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK; no data), such as type 2 diabetes, and to the compounds I and methods for preparing them. Twelve pharmaceutical compositions are included. For I: m is 0-2; n is 0-4; and n + m > 0; each R1 = OH, -(CH2)1-4OH, -CH3-aFa, -(CH2)1-44CH3-aFa, -OCH3-aFa, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, NH2, -NH-C1-4alkyl, -N-di(C1-4alkyl), CN, formyl, Ph or heterocyclyl optionally substituted by C1-6alkyl. Each R2 is the group Y-X- wherein each X is a linker = -O-Z-, -O-Z-O-Z-, -C(O)O-Z-, -OC(O)-Z-, -S-Z-, -SO-Z-, -SO2-Z-, -N(R6)-Z-, -N(R6)SO2-Z-, -SO2N(R6)-Z-, -(CH2)1-4-, -CH:CH-Z-, -CC-Z-, -N(R6)CO-Z-, -CON(R6)-Z-, -C(O)N(R6)S(O)2-Z-, -S(O)2N(R6)C(O)-Z-, -C(O)-Z-, -Z-, -C(O)-Z-O-Z-, -N(R6)-C(O)-Z-O-Z-, -O-Z-N(R6)-Z-, -O-C(O)-Z-O-Z- or a direct bond; each Z = a direct bond, C2-6alkenylene or -(CH2)p-C(R6a)2-(CH2)q-; each Y = aryl-Z1-, heterocyclyl-Z1-, C3-7cycloalkyl-Z1-, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, -(CH2)1-4CH3-aFa or -CH(OH)CH3-aFa; R3 = Ph or a heterocyclyl; addnl. details are given in the claims. More than 30 example preparations of I are included and >300 specific examples of I are included with characterization data. For example, to prepare 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole, diisopropylethylamine (2.0 mmol) then 4-dimethylaminopyridine (0.1 mmol) were added to a solution of 2-aminothiazole (1.0 mmol) and 3,5-di(2-chlorobenzyloxy)benzoic acid chloride (1.0 mmol) in CH2Cl2 (10 mL) under Ar at ambient temperature After 80 mins the reaction mixture was filtered, washed with CH2Cl2 and dried under high vacuum to give the title compound as a colorless solid (41%). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).HPLC of Formula: 64987-16-2

The Article related to benzamide preparation glucokinase inhibitor type 2 diabetes obesity, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nazarov, V. N.; Marchenko, Ya. S.; Taran, S. V.; Ignatenko, O. N. published an article in 2006, the title of the article was Acylation of amines by diphenic anhydride.Synthetic Route of 92-36-4 And the article contains the following content:

The acylation reaction of various aliphatic, aromatic and heterocyclic amines, hydrazines and hydrazides with diphenic anhydride has been investigated. The corresponding monoamides have been exclusively obtained. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4

The Article related to amine hydrazine hydrazine primary acylation diphenic anhydride, amide carboxybiphenyl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Synthetic Route of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 15, 2001, Corbett, Wendy Lea; Haynes, Nancy-Ellen; Sarabu, Ramakanth published a patent.Formula: C6H8N2O2S The title of the patent was Preparation of substituted phenylacetamides and their use as glucokinase activators. And the patent contained the following:

The title compounds 4-R[(CH2)yX]zC6H4CH(CH2R1)CONHR2 [X = O, SO2; R is a ring; R1 is cycloalkyl; y and z are 0 or 1; R2 is -CONHR3 or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom], active as glucokinase activators to increase insulin secretion, were prepared E.g., 2-biphenyl-4-yl-3-cyclopentyl-N-thiazol-2-ylpropionamide was prepared by reaction of 4-biphenylacetic acid with iodomethylcyclopentane, followed by treatment with 2-aminothiazole. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S

The Article related to phenylacetamide preparation glucokinase activator, acetamide phenyl preparation glucokinase activator, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica