Day: October 28, 2022

On July 9, 2020, Maccallini, Cristina; Arias, Fabio; Gallorini, Marialucia; Amoia, Pasquale; Ammazzalorso, Alessandra; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Cataldi, Amelia; Camacho, Maria Encarnacion; Amoroso, Rosa published an article.SDS of cas: 2010-06-2 The title of the article was Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation. And the article contained the following:

In the present work a set of aryl and amido-aryl acetamidine derivatives were synthesized to obtain new potent and selective inducible Nitric Oxide Synthase inhibitors with improved physicochem. parameters with respect to the previously published mols. Compound I emerged as the most promising inhibitor, and was evaluated on C6 rat glioma cell line, showing antiproliferative effects and high selectivity over astrocytes. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to aryl acetamidine hydrobromide preparation nitric oxide synthase inhibition sar, amidoaryl acetamidine preparation antitumor nitric oxide synthase inhibition sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 5, 2020, Jacobsen, Eric Jon; Anderson, David Randolph; Blinn, James Robert; Mukherjee, Paramita; Changelian, Paul; Xu, Canxin published a patent.Recommanded Product: 1092942-42-1 The title of the patent was Substituted pyrrolopyridines as JAK inhibitors and their preparation and their preparation. And the patent contained the following:

The invention relates to pyrrolopyridine compounds having the structures of formula I, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis. Compounds of formula I wherein R1 is CN and (un)substituted heteroaryl; R2 is H, (un)substituted C1-4 alkyl, (un)substituted C3-6 cycloalkyl and (un)substituted C1-2 alkyl-C3-6 cycloalkyl; Q is absent, CH2 and CH2CH2; R3 is H, halo, (un)substituted C1-4 alkyl, (un)substituted C3-6 cycloalkyl, etc.; two R3 groups may be taken together to form a spirocyclic or bicyclic ring system; R4 is COR6, CH2R5, COC1-5 alkyl and COC3-6 cycloalkyl; R6 is C1-5 alkyl, C3-6 cycloalkyl, aryl, aryloxy, etc.; and derivatives thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their JAK inhibitory activity (data given). The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Recommanded Product: 1092942-42-1

The Article related to pyrrolopyridine preparation jak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 1092942-42-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 4, 2021, Anderson, David Randolph; Jacobsen, Eric Jon; Blinn, James Robert; Hockerman, Susan Landis; Mukherjee, Paramita; Changelian, Paul published a patent.Synthetic Route of 1092942-42-1 The title of the patent was Substituted sulfonamide pyrrolopyridines as JAK inhibitors and their preparation. And the patent contained the following:

The invention relates to sulfonamide pyrrolopyridine compounds of formula I and compositions useful in the treatment of JAK-mediated conditions. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided. Exemplary indications treated by inhibition of JAK kinase activity include, but are not limited to, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, irritable bowel syndrome, and Celiac disease. Compounds of formula I wherein R1 is CN, CO2C1-6 alkyl and (un)substituted 5- to 10-membered heteroaromatic ring; R2 and R3 are independently H, (un)substituted C1-4 alkyl and (un)substituted C0-2 alkyl-C3-6 cycloalkyl; R4 is (un)substituted C1-6 alkyl, (un)substituted C0-4 alkyl-C3-6 cycloalkyl, (un)substituted C2-5 alkyl-COC0-4 alkyl-C3-6 cycloalkyl, etc.; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for the JAK inhibitory activity (data given). The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Synthetic Route of 1092942-42-1

The Article related to pyrrolopyridine sulfonamide preparation jak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 1092942-42-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhuravel’, I. O.; Kovalenko, S. M.; Ivashchenko, A. V.; Chernykh, V. P. published an article in 2005, the title of the article was Construction of the combinatorial libraries of 5-hydroxymethyl-2-imino-8-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides.SDS of cas: 92-36-4 And the article contains the following content:

Using the parallel solution-phase synthesis combinatorial libraries of 5-hydroxymethyl-2-imino-8-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides, 5-hydroxymethyl-2-N-arylimino-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides and their acyclic derivatives were obtained. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).SDS of cas: 92-36-4

The Article related to pyranopyridine preparation biol activity prediction, pyridoxal hydrochloride cyanoacetarylamide cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 15, 2005, Zhuravel’, Irina O.; Kovalenko, Sergiy M.; Ivachtchenko, Alexandre V.; Balakin, Konstantin V.; Kazmirchuk, Victor V. published an article.HPLC of Formula: 92-36-4 The title of the article was Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides. And the article contained the following:

Several 2-imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-(N-aryl)carboxamides, e.g., I, were prepared by reaction of pyridoxal hydrochloride with various N-aryl cyanoacetamides. Reaction of these compounds with aromatic amines furnished a wide series of 2-(N-R-phenyl) imino-5-hydroxymethyl-8-methyl-2H-pyrano[2,3-c]pyridine-3-carboxamides. Antibacterial and antifungal activities of the synthesized compounds were studied. Most of the obtained compounds demonstrated significant activity against bacterial or fungal strains (MIC in the range of 12.5-25 μg/mL), displaying comparable or even better efficacy than the standard drugs. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).HPLC of Formula: 92-36-4

The Article related to pyridoxal cyanoacetamide cyclization, iminopyranopyridinecarboxamide preparation arylamine arylation, arylimino pyranopyridinecarboxamide preparation antimicrobial, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.HPLC of Formula: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 15, 2020, Api, A. M.; Belsito, D.; Botelho, D.; Bruze, M.; Burton, G. A. Jr.; Buschmann, J.; Dagli, M. L.; Date, M.; Dekant, W.; Deodhar, C.; Francis, M.; Fryer, A. D.; Jones, L.; Joshi, K.; La Cava, S.; Lapczynski, A.; Liebler, D. C.; O′Brien, D.; Patel, A.; Penning, T. M.; Ritacco, G.; Romine, J.; Sadekar, N.; Salvito, D.; Schultz, T. W.; Sipes, I. G.; Sullivan, G.; Thakkar, Y.; Tokura, Y.; Tsang, S. published an article.Application of 24295-03-2 The title of the article was RIFM fragrance ingredient safety assessment, 2-acetylthiazole, CAS Registry Number 24295-03-2. And the article contained the following:

The existing information supports the use of this material as described in this safety assessment. 2-Acetylthiazole was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that 2-acetylthiazole is not genotoxic. The skin sensitization endpoint was completed using the dermal sensitization threshold (DST) for non-reactive materials (900 μg/cm2); exposure is below the DST. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the threshold of toxicol. concern (TTC) for a Cramer Class II material, and the exposure to 2-acetylthiazole is below the TTC (0.009 mg/kg/day, 0.009 mg/kg/day, and 0.47 mg/day, resp.). The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; 2-acetylthiazole is not expected to be phototoxic/photoallergenic. The environmental endpoints were evaluated, 2-acetylthiazole was found not to be persistent, bioaccumulative, and toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current Volume of Use in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]) are <1. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2

The Article related to developmental, environmental safety, genotoxicity, local respiratory toxicity, phototoxicity/photoallergenicity, repeated dose, reproductive, skin sensitization, toxicity and other aspects.Application of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2021, Li, Zhuoke; Cao, Jun; Mao, Ting; Dan, Ni published an article.Name: 2-Acetylthiazole The title of the article was Synthesis of bimannich base with thiazole and its corrosion inhibition effect on H2S and CO2 at high temperature. And the article contained the following:

A bimannich-based TZBM containing a thiazole ring was obtained by synthesis of mannich bases. TZBM featured a stable structure at 260 °C, and corrosion inhibition effect on carbon steel in a gas-liquid environment with Cl- + H2S + CO2 at 180 °C. By analyzing the weight loss of steel exposed to different TZBM concentrations, the coverages of the inhibitor adsorbed on the surfaces were determined, and the results conformed to Langmuir isotherm model. Furthermore, the neg. Gibbs free energy indicated that the adsorption was a spontaneous process. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Name: 2-Acetylthiazole

The Article related to thiazole bimannich base hydrogen sulfide carbon dioxide, high temperature corrosion inhibition, bimannich base, corrosion inhibitor, high temperature resistance, thiazole and other aspects.Name: 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Althagafi, Ismail; El-Metwaly, Nashwa M.; Farghaly, Thoraya published an article in 2019, the title of the article was Characterization of new Pt(IV)-thiazole complexes: Analytical, spectral, molecular modeling and molecular docking studies and applications in two opposing pathways.Application of 2010-06-2 And the article contains the following content:

New thiazole derivatives were synthesized and fully characterized, then coordinated with PtCl4 salt. Also, the newly synthesized Pt(IV) complexes were studied anal. (elemental and thermogravimetric analyses), spectrally (IR, UV-visible, mass, 1H NMR, 13C NMR, x-ray diffraction) as well as theor. (kinetics, modeling and docking). The data extracted led to the establishment of the best chem. and structural forms. Octahedral geometry was the only formula proposed for all complexes, which is favorable for d6 systems. The mol. ion peaks from mass spectral anal. coincide with all anal. data, confirming the mol. formula proposed. XRD and SEM allowed discrimination of features between crystalline particles and other amorphous morphol. By applying Gaussian09 as well as HyperChem 8.2 programs, the best structural forms were obtained, as well as computed significant parameters. Computed parameters such as softness, hardness, surface area and reactivity led the authors towards application in two opposing pathways: tumor inhibition and oxidation activation. The catalytic oxidation for CO was conducted over PtO2, which was yielded from calcination of the most reactive complex. The success of catalytic role for synthesized PtO2 was due to its particulate size and surface morphol., which were estimated from XRD patterns and SEM images, resp. The antitumor activity was tested vs. HCT-116 and HepG-2 cell lines. Mild toxicity was recorded for two of the derivatives and their corresponding complexes. This degree of toxicity is more favorable in most cases, due to exclusion of serious side effects, which is coherently attached with known antitumor drugs. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application of 2010-06-2

The Article related to aminothiazole derivative platinum complexation electronic structure mol docking, platinum aminothiazole derivative preparation antitumor activity thermolysis kinetics qsar and other aspects.Application of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On December 31, 2020, Sun, Huahua; Liu, Feng; Ye, Zi; Baker, Adam; Zwiebel, Laurence J. published an article.Reference of 2-Acetylthiazole The title of the article was Mutagenesis of the orco odorant receptor co-receptor impairs olfactory function in the malaria vector Anopheles coluzzii. And the article contained the following:

Mosquitoes rely heavily on their olfactory systems for host seeking, selection of oviposition sites, and avoiding predators and other environmental dangers. Of these behaviors, the preferential selection of a human blood-meal host drives the vectorial capacity of anthropophilic female Anopheles coluzzii mosquitoes. Olfactory receptor neurons (ORNs) are dispersed across several appendages on the head and express an obligate odorant receptor co-receptor (Orco) coupled with a ”tuning” odorant receptor (OR) to form heteromeric, odor-gated ion channels in the membrane of these neurons. To examine the mechanistic and functional contributions of Orco/OR complexes to the chemosensory processes of An. coluzzii, we utilized CRISPR/Cas9 gene editing to create a line of homozygous, Orco-knockout, mutant mosquitoes. As expected, orco-/- ORNs across both adult and larval stages of An. coluzzii display significantly lower background activity and lack nearly all odor-evoked responses. In addition, blood-meal-seeking, adult female, orco-/- mutant mosquitoes exhibit severely reduced attraction to human- and non-human-derived odors while gravid females are significantly less responsive to established oviposition attractants. These results reinforce observations in other insects that Orco is crucial in maintaining the activity of ORNs. In that light, it significantly influences a range of olfactory-driven behaviors central to the anthropophilic host preference that is critical to the vectorial capacity of An. coluzzii as a primary vector for human malaria. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole

The Article related to anopheles coluzzii orco odorant receptor mutagenesis olfactory function, anopheles coluzzii, crispr/cas9, host seeking, odorant receptor co-receptor, olfaction, oviposition and other aspects.Reference of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 22, 2021, Nguyen, Minh T.; Jones, Richard A.; Holliday, Bradley J. published an article.SDS of cas: 24295-03-2 The title of the article was Incorporation of spin-crossover cobalt(II) complexes into conducting metallopolymers: Towards redox-controlled spin change. And the article contained the following:

Metal complexes from cobalt(II/III) ions with two tridentate ligands and the corresponding conducting metallopolymers have been synthesized, characterized and subjected to magnetic studies which revealed a redox-controlled spin change. These complexes were designed to contain both a possible spin-crossover metal complex core and an electropolymerizable group for the production of the corresponding conducting metallopolymers. SQUID magnetic measurements revealed a gradual thermal spin crossover (T1/2 = 170 K) and a low spin state up to 400 K for the two complexes with terpyridine ligand cores chelating to Co(II) and Co(III) centers, resp., supporting the viability of a spin change from paramagnetic (Co(II), S = 3/2) to diamagnetic (Co(III), S = 0) states via redox chem. We have also demonstrated that the reported cobalt(II) complexes can undergo a facile polymer growth process under electropolymerization conditions. Electrochem. studies revealed that the Co(II) and Co(III) metal centers in poly-CoIIL1 could be reversibly interconverted, which demonstrates that the magnetic properties of the conducting metallopolymers can be switched between paramagnetic and diamagnetic. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).SDS of cas: 24295-03-2

The Article related to cobalt terpyridine thiazolylpyridine complex preparation electropolymerization electrochem magnetic property, crystal structure cobalt terpyridine thiazolylpyridine complex and other aspects.SDS of cas: 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica