On May 7, 2015, Burnett, Duane A.; Bursavich, Matthew Gregory; McRiner, Andrew J. published a patent.Reference of Benzo[d]thiazol-6-ylmethanol The title of the patent was Spiro-oxadiazoline compounds as agonists of α-7-nicotinic acetylcholine receptors and their preparation. And the patent contained the following:
The invention relates to spiro-oxadiazoline compounds of formula I, II, and III, that are suitable as agonists or partial agonists of α7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline α7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom. Compounds of formula I, II and III wherein R1 is H, C1-6 alkyl, C3-6 cycloalkyl, heteroaryl, etc.; n is 0 to 6; W is (un)substituted 5- to 6-membered heteroaryl, (un)substituted 9- to 10-membered bicyclic heteroaryl, (un)substituted aryl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclocondensation of N-hydroxybenzimidamide with 3-quinuclidinone hydrochloride. The invention compounds were evaluated for their α7-nAChR agonistic activity. From the assay it was determined that compound IV exhibited 65% inhibition at 10 μM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Reference of Benzo[d]thiazol-6-ylmethanol
The Article related to spirooxadiazoline preparation alpha7 nachr agonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Reference of Benzo[d]thiazol-6-ylmethanol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica