On October 25, 2007, Feng, Zewang; Sun, Chenghui; Zhao, Xinqi published an article.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the article was Synthesis of 2-(2-benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid. And the article contained the following:
2-(2-Benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid (1), the key intermediate of ceftibuten, was prepared from Me (2-aminothiazol-4-yl) acetate, which could be easily bought in China through a three-step reaction of amino group protection, Michael addition elimination and selective esterification with an overall yield of 63.0%. This facile and lower-cost process was suitable for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to benzyloxycarbonylaminothiazol methylbutenyloxycarbonyl pentenoic acid ceftibuten synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica