Day: October 31, 2022

On October 31, 2012, Lei, Ying-jie; Bi, Ye; Ouyang, Jie; Ding, Mei published an article.Electric Literature of 92-36-4 The title of the article was Synthesis of 2-(4-aminophenyl)-6-benzothiazoles derivatives in the presence of manganese(III) acetate. And the article contained the following:

Several 4-nitrophenybenzothiazole intermediates were prepared by condensation reaction of 2-aminothiophenol and(substituted) 4-nitrobenzaldehyde in the presence of manganese(III) acetate and the procedure was shown to be mild and easy, which was followed with a reduction under the Pd/C catalyst to afford the desired amino derivatives and resulted in yields of 63-79%. The formation of the corresponding products was confirmed by IR, 1HNMR and elemental anal. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Electric Literature of 92-36-4

The Article related to synthesis aminophenylbenzothiazole derivative manganese acetate, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Electric Literature of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 25, 2007, Feng, Zewang; Sun, Chenghui; Zhao, Xinqi published an article.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the article was Synthesis of 2-(2-benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid. And the article contained the following:

2-(2-Benzyloxycarbonylaminothiazol-4-yl)-5-(3-methyl-2-butenyloxycarbonyl) pent-2-enoic acid (1), the key intermediate of ceftibuten, was prepared from Me (2-aminothiazol-4-yl) acetate, which could be easily bought in China through a three-step reaction of amino group protection, Michael addition elimination and selective esterification with an overall yield of 63.0%. This facile and lower-cost process was suitable for industrial production The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to benzyloxycarbonylaminothiazol methylbutenyloxycarbonyl pentenoic acid ceftibuten synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On October 1, 2009, Muthuppalniappan, Meyyappan; Kumar, Sukeerthi; Thomas, Abraham; Khairatkar-Joshi, Neelima; Mukhopadhyay, Indranil published a patent.Synthetic Route of 31699-14-6 The title of the patent was Preparation of phthalimide derivatives as TRPA1 modulators. And the patent contained the following:

The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds I [ring A = (hetero)aryl, heterocyclyl, cycloalkyl; R1 = H, OH, (un)substituted alkyl, etc.; R2 = H, CN, NO2, etc.; R3, R4 = H, OH, halo, etc.; or R3 and R4 may be joined together to form (un)substituted 3-7 membered (un)saturated cyclic ring which may optionally include at least one heteroatom such as O, S, (un)substituted NH, C(O), S(O)0-2; R5 = H, OH, (un)substituted alkyl, etc.] are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) modulators. Forty-four compounds I were prepared Thus, coupling the acid II (multi-step synthesis was given) with 4-isopropylaniline afforded the title compound III. Exemplified compounds I were screened for TRPA1 antagonist activity using the 45Calcium uptake assay (data given). Also provided are processes for preparing compounds I, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Synthetic Route of 31699-14-6

The Article related to phthalimide amide preparation transient receptor potential a trpa1 modulator, isoindolylacetamide preparation transient receptor potential a trpa1 modulator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 31699-14-6

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lemir, Ignacio D.; Castro-Godoy, Willber D.; Heredia, Adrian A.; Schmidt, Luciana C.; Arguello, Juan E. published an article in 2019, the title of the article was Metal- and photocatalyst-free synthesis of 3-selenylindoles and asymmetric diarylselenides promoted by visible light.Quality Control of 4-Phenylthiazol-2-amine And the article contains the following content:

A novel and sustainable procedure was developed for the synthesis of 3-selenylindoles I = [R1 = H, Me, H2CCH2CH=CH2; R2 = H, Me; R3 = Me, Ph, Bn, etc.] employing diorganyl diselenides and indoles as starting materials. The methodol. was extended to electron-rich arenes to produce diarylselenides. Visible blue light was used to promote the reaction without employing transition metal complexes or organic photocatalysts as sensitizers. Additives such as strong oxidants or bases were not required. Moreover, ethanol was employed as a benign solvent under mild reaction conditions. Through this easy and eco-friendly approach, several 3-selenylindoles I and a number of asym. diarylselenides Ar1SeR4 [Ar1 = Ph; R4 = 4-N(Me)2C6H4, 2,4,6-(HO)3C6H2, etc.] were obtained in good to excellent isolated yields. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine

The Article related to diselenide indole visible light aerobic photochem, selenylindole regioselective green preparation photochem, diaryl selenide regioselective green preparation photochem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 4-Phenylthiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 28, 2022, Reddy, A. VenkatRam; Reddy, L. Krishna Kanth; Reddy, V. Sudheer; Douglas, S. Paul published an article.Application of 24295-03-2 The title of the article was Design, synthesis, and biological evaluation of chalcone based derivatives of 1,3,4-thiadiazole-oxazole as cytotoxic agents. And the article contained the following:

A new series of chalcone-incorporated 1,3,4-thiadiazole-oxazoles I [R = 3,4,5-(MeO)3C6H2, 4-pyridyl, 2-thiazolyl, etc.] have been prepared and their chem. structures were confirmed by spectroscopic techniques. Further, all compounds were explored for their cytotoxic activity towards human cervix cancer (SiHa), human lung cancer (A549), human breast cancer (MCF-7) and human colon cancer (Colo-205) cell lines by employing MTT assay. The known chemotherapeutic drug candidate etoposide was used as pos. control. According to the data, all the compounds showed good to moderate activities. Among them, compounds I [R = 3,4,5-(MeO)3C6H2, 3,5-(MeO)2C6H3, 4-pyridyl, 2-thiazolyl] displayed most promising activity. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2

The Article related to thiadiazole oxazole chalcone preparation antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 24295-03-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On May 7, 2015, Burnett, Duane A.; Bursavich, Matthew Gregory; McRiner, Andrew J. published a patent.Reference of Benzo[d]thiazol-6-ylmethanol The title of the patent was Spiro-oxadiazoline compounds as agonists of α-7-nicotinic acetylcholine receptors and their preparation. And the patent contained the following:

The invention relates to spiro-oxadiazoline compounds of formula I, II, and III, that are suitable as agonists or partial agonists of α7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline α7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom. Compounds of formula I, II and III wherein R1 is H, C1-6 alkyl, C3-6 cycloalkyl, heteroaryl, etc.; n is 0 to 6; W is (un)substituted 5- to 6-membered heteroaryl, (un)substituted 9- to 10-membered bicyclic heteroaryl, (un)substituted aryl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclocondensation of N-hydroxybenzimidamide with 3-quinuclidinone hydrochloride. The invention compounds were evaluated for their α7-nAChR agonistic activity. From the assay it was determined that compound IV exhibited 65% inhibition at 10 μM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Reference of Benzo[d]thiazol-6-ylmethanol

The Article related to spirooxadiazoline preparation alpha7 nachr agonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Reference of Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 5, 2020, Zych, Dawid; Slodek, Aneta; Malecki, Jan Grzegorz published an article.Safety of 2-Acetylthiazole The title of the article was 2,2′:6′,2”-Terpyridine derivative with tetrazole motif and its analogues with 2-pyrazinyl or 2-thiazolyl substituents – Experimental and theoretical investigations. And the article contained the following:

The synthesis of 4′-[4-(2-decyl-1,3,4-tetrazol-5-yl)phenyl]-2,2′:6′,2”-terpyridine and its analogs which contain substitutions at the central pyridine ring (positions 2 and 6) 2-pyrazinyl or 2-thiazolyl groups was reported. Photophys., optical studies and theor. calculations anal. with particular emphasis on the difference caused by the change of substituents was presented. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Safety of 2-Acetylthiazole

The Article related to decyltetrazolyl teraryl preparation thermal stability, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 2-Acetylthiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 9, 2017, Smallheer, Joanne M.; Shaw, Scott A.; Halpern, Oz Scott; Hu, Carol Hui; Kick, Ellen K. published a patent.Application In Synthesis of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of triazolopyridines as inhibitors of myeloperoxidase. And the patent contained the following:

The invention provides compounds of formula I and compositions comprising any of such compounds These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments. Compounds of formula I wherein A is (un)substituted 5-membered heteroaryl; and stereoisomers, tautomers, pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II•TFA was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their MPO inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 1 nM to 100 nM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Application In Synthesis of Benzo[d]thiazol-6-ylmethanol

The Article related to triazolopyridine preparation myeloperoxidase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Benzo[d]thiazol-6-ylmethanol

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On September 30, 2006, Gadre, J. N.; Periaswamy, R. M. S.; Mulay, Mohit; Vaze, C. S. published an article.Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole The title of the article was Synthesis of pyridone based azo disperse dyes. And the article contained the following:

Pyridone derivatives have proved to be the best heterocyclic couplers as they provide proper nucleophilic center. In the present project N-aryl imides (pyridine-2,6-dione) were coupled with diazotized substituted aniline derivatives to yield azo disperse dyes. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole

The Article related to pyridone based azo disperse dye aryl imide pyridinedione aniline, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Azo Dyes and Pigments and other aspects.Reference of 2-(4-Aminophenyl)-6-methylbenzothiazole

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On June 26, 2012, Bouillot, Anne Marie Jeanne; Laroze, Alain published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Triazole derivatives as scd inhibitors. And the patent contained the following:

The present invention relates to substituted triazole compounds of the formula (I):and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for inhibiting SCD activity, such as diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, skin disorders such as acne, diseases or conditions related to cancer and the treatment of symptoms linked to the production of the amyloid plaque-forming Aβ42 peptide such as Alzheimer’s disease and the like. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

The Article related to triazole preparation stearoyl coa desaturase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica