On February 28, 2022, Reddy, A. VenkatRam; Reddy, L. Krishna Kanth; Reddy, V. Sudheer; Douglas, S. Paul published an article.Application of 24295-03-2 The title of the article was Design, synthesis, and biological evaluation of chalcone based derivatives of 1,3,4-thiadiazole-oxazole as cytotoxic agents. And the article contained the following:
A new series of chalcone-incorporated 1,3,4-thiadiazole-oxazoles I [R = 3,4,5-(MeO)3C6H2, 4-pyridyl, 2-thiazolyl, etc.] have been prepared and their chem. structures were confirmed by spectroscopic techniques. Further, all compounds were explored for their cytotoxic activity towards human cervix cancer (SiHa), human lung cancer (A549), human breast cancer (MCF-7) and human colon cancer (Colo-205) cell lines by employing MTT assay. The known chemotherapeutic drug candidate etoposide was used as pos. control. According to the data, all the compounds showed good to moderate activities. Among them, compounds I [R = 3,4,5-(MeO)3C6H2, 3,5-(MeO)2C6H3, 4-pyridyl, 2-thiazolyl] displayed most promising activity. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Application of 24295-03-2
The Article related to thiadiazole oxazole chalcone preparation antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 24295-03-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica