Month: October 2022

Luo, Kai; Chen, Yao-Zhong; Chen, Li-Xian; Wu, Lei published the artcile< Autoxidative C(sp2)-P Formation: Direct Phosphorylation of Heteroarenes under Oxygen, Metal-Free, and Solvent-Free Conditions>, Category: thiazole, the main research area is phosphorylation heteroarene arylphosphine oxide; heteroaryl phosphine oxide preparation.

The authors reveal here a direct autoxidative phosphorylation of heteroarenes induced by O under metal-free and solvent-free conditions. This new methodol. provides an economical, operationally simple, and environmentally friendly approach toward (Het)C(sp2)-P formation with medium to excellent yields. Heteroarenes including thiazole and quinoxaline derivatives are applicable under standard conditions, which is testified via a radical mechanism.

Journal of Organic Chemistrypublished new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroarenes). 20582-55-2 belongs to class thiazole, and the molecular formula is C7H9NO2S, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Inouye, Satoshi; Sahara-Miura, Yuiko; Nakamura, Mitsuhiro; Hosoya, Takamitsu published the artcile< Expression, purification, and characterization of recombinant apoPholasin>, COA of Formula: C11H8N2O3S2, the main research area is apoPholasin glutathione transferase coelenterazine reactive oxygen species oxidation; Coelenteramide; Coelenteramine; Dehydrocoelenterazine; Photoproteins; Reactive oxygen.

Pholasin is a reactive oxygen-sensitive photoprotein that consists of an apoprotein (apoPholasin) and an unknown chromophore. The preferred human codon-optimized apoPholasin gene was transiently expressed in mammalian cells and apoPholasin was detected using an anti-recombinant apoPholasin antibody. For the first time, we found that apoPholasin secreted into the culture medium could catalyze the oxidation of coelenterazine (CTZ, a luciferin) to produce continuous luminescence. The fusion protein of apoPholasin and glutathione S-transferase (GST-apoPholasin) was successfully expressed as a soluble form in bacterial cells using the cold induction system. The purified GST-apoPholasin also had luminescence activity with CTZ, showing the bioluminescence emission peak at 461 nm, and the resultant product showed purple blue fluorescence under 365 nm light. Unexpectedly, the main oxidation product of CTZ was identified as coelenteramine (CTM), not coelenteramide (CTMD).

Protein Expression and Purificationpublished new progress about Absorption. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, COA of Formula: C11H8N2O3S2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Sun, Wencheng; Teng, Qiaoling; Cheng, Dongping; Li, Xiaonian; Xu, Xiaoliang published the artcile< The hydrodebromination of 1,1-dibromoalkenes via visible light catalysis>, Electric Literature of 1003-32-3, the main research area is dibromoalkene preparation iridium photocatalyst diastereoselective hydrodebromination green chem; bromoalkene preparation.

A hydrodebromination reaction of 1,1-dibromoalkenes was established via visible light catalysis. A variety of structurally different vinyl bromides were obtained in moderate to excellent yields.

Tetrahedron Letterspublished new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Electric Literature of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wu, Yue-Xiao; Peng, Kang; Hu, Zhi-Chao; Fan, Yong-Hao; Shi, Zhen; Hao, Er-Jun; Dong, Zhi-Bing published the artcile< Iodine-Mediated Cross-Dehydrogenative Coupling of Heterocyclic Thiols with Amines: An Easy and Practical Formation of S-N Bond>, Quality Control of 96-53-7, the main research area is amine heteroaryl thiol iodine promoter cross dehydrogenative coupling; heteroaryl sulfenamide preparation.

An efficient iodine-mediated construction of S-N bond was developed. Such a cross-dehydrogenative coupling of heterocyclic thiols with amines proceeded smoothly under metal-free and base-free conditions, and afforded a series of sulfenamides in good to excellent yields. The easily available substrates and convenient synthetic procedure illustrate potential synthetic value of this protocol for the preparation of sulfenamide related biol. or pharmaceutically active compounds

European Journal of Organic Chemistrypublished new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Quality Control of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Telegina, Lyudmila N.; Kelbysheva, Elena S.; Strelkova, Tatyana V.; Ezernitskaya, Mariam G.; Smol’yakov, Alexander F.; Borisov, Yurii A.; Loim, Nikolay M. published the artcile< Synthesis and Photochemical Study of Thiazolidine Derivatives of Cymantrene and the Corresponding Dicarbonyl Chelates>, Recommanded Product: 4,5-Dihydrothiazole-2-thiol, the main research area is cymantrenylmethylthio thiazole preparation reaction; thiazolidinethione cymantrenylmethylthio preparation reaction; chelated cymantrenylmethylthio thiazolidine preparation crystal mol structure; photochem thiazolidine derivative cymantrene dicarbonyl chelate.

Isomeric 4,5-dihydro-2-[(cymantrenylmethyl)thio]thiazole (1) and 3-(cymantrenylmethyl)-1,3-thioazolidine-2-thione (2) were synthesized and photochem. behavior and spectral characteristics of tricarbonyl and dicarbonyl complexes were studied. Irradiation of compounds 1 and 2 results in the formation of stable chelates due to coordination of manganese to the donor nitrogen and sulfur atoms of the thiazolidine substituent. Photolysis is accompanied with a color change and the corresponding changes in the UV/Vis spectra depending on the solvent used. In the presence of CO, the dicarbonyl chelates enter the dark reaction to give the parent tricarbonyl complexes thus forming intermol. photochromic systems. Photolysis of the dicarbonyl chelate 5 gives the isomeric chelate 6, which in the course of the dark isomerization transforms into complex 5. Chelates 5 and 6 form an intramol. photochromic pair.

ChemistrySelectpublished new progress about Chelates Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), PROC (Process), RACT (Reactant or Reagent), PREP (Preparation). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Recommanded Product: 4,5-Dihydrothiazole-2-thiol.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Cheng, Lin; Su, Lantian; Tian, Xiaowen; Xia, Fan; Zhao, Chang; Yan, Wei; Shao, Zhenhua published the artcile< A pipeline to investigate the structures and signaling pathways of sphingosine 1-phosphate receptors>, Related Products of 115144-35-9, the main research area is sphingosine 1 phosphate receptor structure signaling pathway investigation.

Lysophospholipids (LPLs) are bioactive lipids that include sphingosine 1-phosphate (S1P), lysophosphatidic acid, etc. S1P, a metabolic product of sphingolipids in the cell membrane, is one of the best-characterized LPLs that regulates a variety of cellular physiol. responses via signaling pathways mediated by sphingosine 1-phosphate receptors (S1PRs). This implicated that the S1P-S1PRs signaling system is a remarkable potential therapeutic target for disorders, including multiple sclerosis (MS), autoimmune disorders, cancer, inflammation, and even COVID-19. S1PRs, a small subset of the class A G-protein coupled receptor (GPCR) family, are composed of five subtypes: S1PR1, S1PR2, S1PR3, S1PR4, and S1PR5. The lack of detailed structural information, however, impedes the drug discovery targeting S1PRs. Here, we applied the cryo-electron microscopy method to solve the structure of the S1P-S1PRs complex, and elucidated the mechanism of activation, selective drug recognition, and G-protein coupling by using cell-based functional assays. Other lysophospholipid receptors (LPLRs) and GPCRs can also be studied using this strategy.

Journal of Visualized Experimentspublished new progress about Autoimmune disease. 115144-35-9 belongs to class thiazole, and the molecular formula is C11H7KN2O3S2, Related Products of 115144-35-9.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ryu, Se Hwan; Ra, Jongmin; Ko, Haye Min published the artcile< Efficient Synthesis of Sulfenamides through Mitsunobu-type Coupling Reaction of Thiols with Amines using Dibenzyl Azodicarboxylate>, Application In Synthesis of 96-53-7, the main research area is sulfenamide preparation; thiol amine Mitsunobu coupling; disulfides preparation.

S-H activation reaction of thiols employing dibenzyl azodicarboxylate (DBAD) had been developed for the preparation of sulfenamides I [R = H; R1 = Et, Bn, cyclopropyl, cyclopentyl, cyclohexyl; RR1 = (CH2)4, (CH2)6, (CH2)2O(CH2)2, etc.; X = O, S]. The dehydrogenation of thiols and amines under these reaction conditions involved the formation of dibenzyl hydrazine-1,2-dicarboxylate, which led to the S-N bond formation reaction. The reaction proceeded efficiently with release of dibenzyl hydrazine-1,2-dicarboxylate and afforded various sulfenamides I in good to excellent yields.

Asian Journal of Organic Chemistrypublished new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Application In Synthesis of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Banerjee, Janmajoy; Mariappan, G.; Nepal, Aswini Kumar; Dahal, Prassana; Khanal, Hemanta published the artcile< Conventional methods of synthesis of novel amino(phenyl)thiazoles and their antibacterial and local anesthetics screening>, COA of Formula: C9H7N3O2S, the main research area is acetamide thiazolylamino preparation anesthetic antibacterial.

Cyclocondensation of thiourea and substituted acetophenones RCOMe [R = Ph, 3-O2NC6H4, 4-O2NC6H4, 4-MeOC6H4, 2,5-(MeO)2C6H3] led to the formation of the corresponding 2-amino-4-R-thiazoles, which on further reaction with N-Ph 2-chloroacetamide gave N-Ph (thiazolylamino)acetamides I. The synthesized compounds I were investigated for their antibacterial activity by cup plate method against four bacterial strains. All the synthesized compounds exhibited mild to good antibacterial activities with I [R = 2,5-(MeO)2C6H3] showing promising activity against all strains of bacteria. The compounds I were also screened for local anesthetics activity taking lidocaine as standard, and all the compounds showed moderate activities.

International Journal of Pharmacy and Technologypublished new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Zhi-Hua; Wu, Hong-Mei; Deng, Sai-Nan; Cai, Xiao-Yu; Yao, Yu; Mwenda, Muriira Cyrus; Wang, Jin-Yin; Cai, Dong; Chen, Yu published the artcile< Design, synthesis, and anticancer activities of novel 2-amino-4-phenylthiazole scaffold containing amide moieties>, Application of C9H7N3O2S, the main research area is morpholinoacetamido thiazolylphenyl benzamide preparation anticancer activity.

Appropriately substituted 2-amino-4-phenylthiazole derivatives I (R = 3-CH3C6H4, 4-BrC6H4, 2-furyl, cyclohexyl, CH3OCH2, ClCH2, etc.) were designed and synthesized according to the structural characteriztics of crizotinib. The target compounds I were evaluated for their in vitro antiproliferative activity against A549, HeLa, HT29, and Karpas299 human cancer cell lines. Based on results of biol. studies, some of these compounds exhibited significant antiproliferative activity. Compound I (R = 3,4-Cl2C6H3) possessed outstanding growth inhibitory effects on the four cell lines, especially for HT29 cell with IC50 value of 2.01 μM. Along with the biol. assay data, a mol. docking study suggests that the target compounds were a potential inhibitor.

Journal of Chemistrypublished new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Application of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Xiaolin; Yang, Hongxia Ou; Ding, Yonghong published the artcile< The synthesis and characterization of potential novel active compounds, 2-aminothiazole derives Schiff bases>, Electric Literature of 57493-24-0, the main research area is aromatic ketone thiourea cyclocondensation; aminothiazole preparation condensation aryl aldehyde; Schiff base preparation.

Some 4-substituted-2-aminothiazoles were prepared starting from aromatic ketones and thiourea in the presence of powered iodine. Then treating 4-substituted-2-aminothiazole with substituted benzaldehyde gave corresponding 2-aminothiazole derivatives Schiff bases in good yield.

Advanced Materials Research (Durnten-Zurich, Switzerland)published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (heteroaryl). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica