Month: October 2022

Li, Hui’s team published research in International Journal of Molecular Sciences in 2019 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C18H24N6O6S4

《Methionine augments antioxidant activity of rice protein during gastrointestinal digestion》 was published in International Journal of Molecular Sciences in 2019. These research results belong to Li, Hui; Wang, Zhengxuan; Liang, Mingcai; Cai, Liang; Yang, Lin. Computed Properties of C18H24N6O6S4 The article mentions the following:

To elucidate the influence of methionine, which is an essential sulfur-containing amino acid, on the antioxidant activity of rice protein (RP), methionine was added to RP (RM). The addition of methionine to RM0.5, RM1.0, RM1.5, RM2.0, and RM2.5 was 0.5-, 1.0-, 1.5-, 2.0-, and 2.5-fold of methionine of RP, resp. Using the in vitro digestive system, the antioxidant capacities of scavenging free radicals (superoxide; nitric oxide; 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, ABTS), chelating metal (iron), and reducing power were investigated in the hydrolyzates of RP and RMs. Upon pepsin-pancreatin digestion, the weakest antioxidant capacity was produced by RP. With the addition of methionine, RMs exhibited more excellent responses to free radical scavenging activities and reducing power than RP, whereas RMs did not produce the marked enhancements in iron chelating activity as compared to RP. The present study demonstrated that RMs differently exerted the free radical scavenging activities that emerged in the protein hydrolyzates, in which the strongest scavenging capacities for ABTS, superoxide, and nitric oxide were RM1.5, RM2.0, and RM2.5, resp. Results suggested that the availability of methionine is a critical factor to augment antioxidant ability of RP in the in vitro gastrointestinal tract. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Liu, Shuo’s team published research in Chemical Research in Chinese Universities in 2020 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Electric Literature of C18H24N6O6S4

《Programmable and Reversible Regulation of Catalytic Hemin@MOFs Activities with DNA Structures》 was written by Liu, Shuo; Yang, Mingjie; Guo, Weiwei. Electric Literature of C18H24N6O6S4 And the article was included in Chemical Research in Chinese Universities on April 30 ,2020. The article conveys some information:

Abstract: Metal-organic frameworks(MOFs)-based nanozyme plays an important role in biosensing, therapy and catalysis. In this study, the effects of single-stranded DNA(ssDNA) with programmable sequences and its complementary DNA(TDNA) on the intrinsic peroxidase-like activity of hemin loaded MOFs(UiO-66-2), denoted as hemin@UiO-66-NH2, were investigated. The hemin@UiO-66-2 exhibited improved catalytic activity compared with free hemin. However, the catalytic activity is inhibited in the presence of ssDNA, as ssDNA can be adsorbed by MOFs and therefore protected the active sites from contact with substrates. Upon the addition of the TDNA, double-stranded DNA(dsDNA) was formed and detached from the MOFs, resulting in the recovery of catalytic activity. Sequentially adding ssDNA or its complementary DNA strands can achieve the reversible regulation of the catalytic activity of MOFs nanozymes. Moreover, the DNA hybridization-based regulation was further applied to a cascaded catalytic system composed of the nanozyme, hemin@UiO-66-NH2, and glucose oxidase. These nanozyme based programmable and reversibly regulated catalytic systems may have potential applications in future smart biosensing and catalysis systems. In addition to this study using ABTS Diammonium, there are many other studies that have used ABTS Diammonium(cas: 30931-67-0Electric Literature of C18H24N6O6S4) was used in this study.

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Electric Literature of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Junren’s team published research in Analytical and Bioanalytical Chemistry in 2020 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 30931-67-0

Recommanded Product: 30931-67-0On November 30, 2020 ,《Eosin Y as a high-efficient photooxidase mimic for colorimetric detection of sodium azide》 appeared in Analytical and Bioanalytical Chemistry. The author of the article were Wang, Junren; Yu, Haili; He, Yi. The article conveys some information:

Abstract: The reported fluorescent dye-based artificial light-responsive oxidase mimics are suffering from their low catalytic efficiency. To overcome the limitation, we report the photooxidase-mimicking activity of Eosin Y which can catalyze the oxidation of various chromogenic substrates such as 3,3′,5,5′-tetramethylbenzydine (TMB), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 3,3′-diaminobenzidine (DAB), and o-phenylenediamine (OPD) by dissolved oxygen. The photooxidase-like activity of Eosin Y is highly efficient for TMB substrate, and its catalytic efficiency is higher than that of the reported fluorescein (130 fold) and 9-mesityl-10-methylacridinium ion (7.7-fold) mimetic photooxidase. Moreover, the photosensitized Eosin Y-TMB chromogenic system is utilized for colorimetric detection of highly toxic and explosive sodium azide (NaN3) in a linear range from 5 to 500 μM with a limit of detection of 3.5 μM. The resulting colorimetric assay is selective and applied to determine NaN3 in real lake water samples. The experimental part of the paper was very detailed, including the reaction process of ABTS Diammonium(cas: 30931-67-0Recommanded Product: 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Mishra, Chandra Bhushan’s team published research in Journal of Medicinal Chemistry in 2021 | CAS: 95-24-9

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application of 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Application of 95-24-9On March 25, 2021, Mishra, Chandra Bhushan; Kumari, Shikha; Angeli, Andrea; Bua, Silvia; Mongre, Raj Kumar; Tiwari, Manisha; Supuran, Claudiu T. published an article in Journal of Medicinal Chemistry. The article was 《Discovery of Potent Carbonic Anhydrase Inhibitors as Effective Anticonvulsant Agents: Drug Design, Synthesis, and In Vitro and In Vivo Investigations》. The article mentions the following:

Two sets of benzenesulfonamide-based effective human carbonic anhydrase (hCA) inhibitors have been developed using the tail approach. The inhibitory action of these novel mols. was examined against four isoforms: hCA I, hCA II, hCA VII, and hCA XII. Most of the mols. disclosed low to medium nanomolar range inhibition against all tested isoforms. Some of the synthesized derivatives selectively inhibited the epilepsy-involved isoforms hCA II and hCA VII, showing low nanomolar affinity. The anticonvulsant activity of selected sulfonamides was assessed using the maximal electroshock seizure (MES) and s.c. pentylenetetrazole (s.c.-PTZ) in vivo models of epilepsy. These potent CA inhibitors effectively inhibited seizures in both epilepsy models. The most effective compounds17(I) and 22(II) showed long duration of action and abolished MES-induced seizures up to 6 h after drug administration. These sulfonamides were found to be orally active anticonvulsants, being nontoxic in neuronal cell lines and in animal models. The experimental process involved the reaction of 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9Application of 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Application of 95-24-9Thiazoles can also be used as protected formyl groups, which can be released in later stages of complex natural product synthesis.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Setoguchi, Masaki’s team published research in Bioorganic & Medicinal Chemistry in 2012 | CAS: 152937-04-7

2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H3BrFNSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Setoguchi, Masaki; Iimura, Shin; Sugimoto, Yuuichi; Yoneda, Yoshiyuki; Chiba, Jun; Watanabe, Toshiyuki; Muro, Fumihito; Iigo, Yutaka; Takayama, Gensuke; Yokoyama, Mika; Taira, Tomoe; Aonuma, Misato; Takashi, Tohru; Nakayama, Atsushi; Machinaga, Nobuo published an article on February 1 ,2012. The article was titled 《Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist》, and you may find the article in Bioorganic & Medicinal Chemistry.Computed Properties of C7H3BrFNS The information in the text is summarized as follows:

For the purpose of obtaining orally potent VLA-4 inhibitors, we have carried out structural modification of the (N’-phenylureido)phenyl group in compound 1, where the group was found to be attributed to poor pharmacokinetic profile in our previous research. Through modification, we have identified several compounds with both potent in vitro activity and improved oral exposure. In particular, compound 7e with 7-fluoro-2-(1-methyl-1H-indol-3-yl)-1,3-benzoxazolyl group as a novel replacement of the (N’-phenylureido)phenyl group significantly inhibited eosinophil infiltration into bronchoalveolar lavage fluid at 15 mg/kg in an Ascaris-antigen-induced murine bronchial inflammatory model, and its efficacy was comparable to that of the anti-mouse α4 antibody (R1-2). In addition to this study using 2-Bromo-6-fluorobenzothiazole, there are many other studies that have used 2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7Computed Properties of C7H3BrFNS) was used in this study.

2-Bromo-6-fluorobenzothiazole(cas: 152937-04-7) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Computed Properties of C7H3BrFNSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Ji-Quan’s team published research in Bioorganic & Medicinal Chemistry Letters in 2006-01-15 | 115144-35-9

Bioorganic & Medicinal Chemistry Letters published new progress about Animal gene, luc Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 115144-35-9 belongs to class thiazole, and the molecular formula is C11H7KN2O3S2, Computed Properties of 115144-35-9.

Wang, Ji-Quan; Pollok, Karen E.; Cai, Shanbao; Stantz, Keith M.; Hutchins, Gary D.; Zheng, Qi-Huang published the artcile< PET imaging and optical imaging with D-luciferin [11C]methyl ester and D-luciferin [11C]methyl ether of luciferase gene expression in tumor xenografts of living mice>, Computed Properties of 115144-35-9, the main research area is luciferin carbon 11 methylester methylether PET luciferase gene tumor; optical imaging luciferase gene expression tumor.

New carbon-11 labeled -luciferin analogs -luciferin [11C]methyl ester ([11C]LMEster, [11C]1) and -luciferin [11C]methyl ether ([11C]LMEther, [11C]2) were synthesized in 25-55% radiochem. yield. PET studies with [11C]LMEster and [11C]LMEther demonstrate a lower retention of the C-11 label at 45 min post-injection in luciferase expression tumor. Optical imaging with unlabeled substrate -luciferin and radiotracers [11C]LMEster and [11C]LMEther gave tumor luciferase images within a few minutes of photon counting.

Bioorganic & Medicinal Chemistry Letters published new progress about Animal gene, luc Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 115144-35-9 belongs to class thiazole, and the molecular formula is C11H7KN2O3S2, Computed Properties of 115144-35-9.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Su, Yichi’s team published research in Nature Methods in 2020-08-31 | 2591-17-5

Nature Methods published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (albumin-Cr). 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, HPLC of Formula: 2591-17-5.

Su, Yichi; Walker, Joel R.; Park, Yunhee; Smith, Thomas P.; Liu, Lan Xiang; Hall, Mary P.; Labanieh, Louai; Hurst, Robin; Wang, David C.; Encell, Lance P.; Kim, Namdoo; Zhang, Feijie; Kay, Mark A.; Casey, Kerriann M.; Majzner, Robbie G.; Cochran, Jennifer R.; Mackall, Crystal L.; Kirkland, Thomas A.; Lin, Michael Z. published the artcile< Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals>, HPLC of Formula: 2591-17-5, the main research area is hydrofurimazine furimazine bioluminescence tumor.

Sensitive detection of two biol. events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a bright bioluminescent reporter with orthogonal substrate specificity to firefly luciferase (FLuc) and its derivatives such as AkaLuc. However, the brightness of Antares in mice is limited by the poor solubility and bioavailability of the NanoLuc substrate furimazine. Here, we report a new substrate, hydrofurimazine, whose enhanced aqueous solubility allows delivery of higher doses to mice. In the liver, Antares with hydrofurimazine exhibited similar brightness to AkaLuc with its substrate AkaLumine. Further chem. exploration generated a second substrate, fluorofurimazine, with even higher brightness in vivo. We used Antares with fluorofurimazine to track tumor size and AkaLuc with AkaLumine to visualize CAR-T cells within the same mice, demonstrating the ability to perform two-population imaging with these two luciferase systems.

Nature Methods published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (albumin-Cr). 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, HPLC of Formula: 2591-17-5.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Demekhin, Oleg D’s team published research in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2022-02-28 | 10574-69-3

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Demekhin, Oleg D.; Burov, Oleg N.; Kletskii, Mikhail E.; Lisovin, Anton V.; Kurbatov, Sergey V.; Bereznyak, Elena A.; Trishina, Alena V. published the artcile< New 13-vinyl derivatives of berberine: synthesis and characterization>, Safety of 3-Benzyl-2-thioxothiazolidin-4-one, the main research area is electroneutral vinyl berberine preparation antibacterial SAR density functional theory.

The possibility of obtaining electroneutral substituted 13-vinylberberines I [R = H, CH2C(O)CH3; R1 = dicyanomethyl, 1,3-dimethoxy-1,3-dioxopropan-2-yl, 2,4,6-trioxo-1,3-diazinan-5-yl, etc.] was demonstrated exptl. and via quantum-chem. DFT/B3LYP calculations in the 6-31++G(d,p) basis set. The introduction of pharmacophoric fragments conjugated through vinyl moiety opened new possibilities for structural modification of berberine, enabling pronounced changes in tropicity toward supramol. biol. structures. The newly synthesized 13-vinylberberines I were stable in their reduced form due to significant intramol. electron d. transfer from berberine ring system to the vinyl moiety bearing electron-withdrawing groups. It was demonstrated that berberine derivatives I may exist not only in ion pair form consisting of organic cation and inorganic anion, but also as zwitterionic structures featuring significant intramol. charge transfer. The obtained 13-vinylberberines I exhibited biol. activity against the highly pathogenic Vibrio cholerae.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Active methylene compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 10574-69-3 belongs to class thiazole, and the molecular formula is C10H9NOS2, Safety of 3-Benzyl-2-thioxothiazolidin-4-one.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Javadi, Ali’s team published research in Journal of Polymer Research in 2018-04-30 | 57493-24-0

Journal of Polymer Research published new progress about Chars. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Javadi, Ali; Shockravi, Abbas; Shourkaei, Fateme Ahmadi; Koohgard, Mehdi; Malek, Ali published the artcile< Highly refractive thiazole-containing polyimides: a structural property comparison>, Product Details of C9H7N3O2S, the main research area is thiazole containing polyimide structural thermal property.

Highly refractive, thermally stable, and solution processable polyimides (PIs) were synthesized by the introduction of thiazole units, thioether linkages, and Ph or nitrophenyl groups into the polymer backbones. These PIs were prepared via the polycondensation of two diamine monomers, 5,5′-thiobis(2-amino-4-phenyl-thiazole) (DA-1) or 5,5′-thiobis(2-amino-4-(3-nitrophenyl)thiazole) (DA-2), with various aromatic dianhydrides (a-d). The bulky pendant Ph or nitrophenyl units as well as the non-coplanar conformations because of ortho-sulfide linkages endowed the resulting PIs with excellent solubility in organic solvents. These PIs showed outstanding thermal stability, with 10% weight loss temperatures exceeding 492 °C under nitrogen and 475 °C in air atm., while their glass transition temperatures were in the range of 239-278 °C. In general, the synergic effects of thiazole groups, Ph or nitrophenyl substituents, and thioether linkages provided PIs with very high refractive indexes of up to 1.7646 at 632.8 nm, along with small birefringences (<0.0085) and high Abbe's numbers The structure-property relationships of the analogous PIs containing Ph or nitrophenyl substituents groups were also studied in detail by comparing the results. Journal of Polymer Research published new progress about Chars. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Product Details of C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Raghavan, Sadagopan’s team published research in European Journal of Organic Chemistry in 2017 | 171877-39-7

European Journal of Organic Chemistry published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Category: thiazole.

Raghavan, Sadagopan; Patel, Javed Sardar published the artcile< A Stereoselective Synthesis of the Carbon Backbone of Phoslactomycin B>, Category: thiazole, the main research area is stereoselective synthesis carbon backbone phoslactomycin B; propargylic sulfide rearrangement unsaturated ketone phoslactomycin B synthesis; aldol stereoselective phoslactomycin B synthesis; asym transfer hydrogenation phoslactomycin B synthesis; diyne partial reduction phoslactomycin B synthesis.

A convergent synthesis of the entire carbon framework of phoslactomycin B (I) is disclosed. An initial route aimed to create the C-8 tetrasubstituted stereocenter through regioselective intermol. coupling between an internal alkyne and an allyl silyl ether, adopting Trost’s protocol, followed by [2,3] sigmatropic rearrangement. But this was not successful. In a second approach, a propargylic sulfide was rearranged to give an unsaturated ketone. This was then treated with lithio acetonitrile to create the C-8 stereocenter selectively. The C-4 and C-5 stereocenters were introduced by a non-Evans syn-aldol reaction using Crimmins’s protocol. The C-9 and C-11 carbinol centers were created by asym. transfer hydrogenation. The (Z,Z)-diene moiety was introduced by partial reduction of a diyne following Hansen’s modification of the Boland reduction reaction.

European Journal of Organic Chemistry published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica