Month: October 2022

Koohgard, Mehdi; Hosseinpour, Zeinab; Sarvestani, Abdollah Masoudi; Hosseini-Sarvari, Mona published an article in 2020, the title of the article was ARS-TiO2 photocatalyzed direct functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions under visible light.Electric Literature of 2010-06-2 And the article contains the following content:

An ARS-TiO2 photocatalyst has been prepared by a simple method through stirring a mixture of ARS and TiO2 at room temperature in the dark to extend the photocatalytic response of titanium dioxide toward the visible light spectrum. The synergic effect of ARS and TiO2 in the photocatalyst system has catalyzed direct C-H functionalization of sp2 C-H bonds toward thiocyanation and cyclization reactions. Several aromatic and heteroaromatic scaffolds (2-phenylamino-thiazoles I (R = H, 2-Cl, 4-Ph, etc.), phenols R1OH (R1 = Ph, 3-ethylphenyl, 2-formylphenyl, etc.), anilines R2C6H4N(R3)(R4) (R2 = 2-Me, 3-Cl, 3-OMe, etc.; R3 = H, Me, Et, Ph; R4 = H, Me, Et), indoles II (R5 = H, Me; R6 = H, Me; R7 = H, 5-MeO, 6-methoxycarbonyl, 5-Br, 5-Me) and pyrroles such as 1H-pyrrole and 1-methyl-1H-pyrrole) were treated with the ammonium thiocyanate at room temperature Thiocyanation of phenol and synthesis of 2-aminobenzothiazole derivatives III (R8 = Me, I, prop-1-en-2-yl, etc.) under visible light are presented. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Electric Literature of 2010-06-2

The Article related to thiocyanation cyclization visible light ars photocatalyst regioselective, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Electric Literature of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On March 31, 2021, Godugu, Kumar; Shaik, Sultana; Mohinuddin Pinjari, Mohammad Khaja; Gundala, Trivikram Reddy; Chellappa Subramanyam, Dwaraka Viswanath; Loka, Subramanyam Sarma; Divi, Haranath; Vemula, Venkatramu; Reddy Nallagondu, Chinna Gangi published an article.COA of Formula: C9H8N2S The title of the article was Solid state thiazole-based fluorophores: Promising materials for white organic light emitting devices. And the article contained the following:

A facile and more efficient solvent-free mechanochem. synthetic route has been developed for the synthesis of a series of solid state white light emissive thiazole-based donor-acceptor (D-A) type fluorophores, 2-(3-pyridyl)/2-aminothiazoles from ω-bromomethylketones and pyridine-3-carbothioamide/thiourea in the presence of silica-supported HClO4 as a reusable solid Bronsted acid catalyst at RT. The photophys. and electrochem. properties of these compounds have been derived. Most of the studied D-A type solid thiazole-based fluorophores emitted white light and it can be tuned from warm – ideal – cold white light by introduction of a variety of substituents at 4th position of 2-(3-pyridyl)/2-aminothiazoles. Further, HOMO and LUMO energy levels of the titled compounds are found to be in the range -5.52 eV to -5.72 eV and -1.84 eV to -2.45 eV, resp. The lifetimes of these levels of thiazole-based fluorophores have been determined through luminescence decay curves and are found to be in the range of 7.7-11μs. The photophys. and electrochem. properties of the synthesized thiazole-based fluorophores indicate that the compounds could be promising materials for white organic light emitting devices. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).COA of Formula: C9H8N2S

The Article related to solid state thiazole fluorophore organic light emitting device, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Structure Correlation With Physical Properties and other aspects.COA of Formula: C9H8N2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On April 30, 2019, Gong, Weinan; Xu, Bin; Yin, Xiaoshuang; Liu, Ying; Chen, Yun; Yang, Wenzhong published an article.Computed Properties of 2010-06-2 The title of the article was Halogen-substituted thiazole derivatives as corrosion inhibitors for mild steel in 0.5 M sulfuric acid at high temperature. And the article contained the following:

The inhibitory effects of three halogen-substituted thiazole derivatives named 2-amino-4-(4-fluorophenyl)-thiazole (FPT), 2-amino-4-(4-chlorophenyl)-thiazole (CPT) and 2-amino-(4-bromophenyl)-thiazole (BPT) on mild steel corrosion were investigated in 0.5 M H2SO4 from 30°C to 60°C. Electrochem. measurements demonstrated that these thiazoles can effectively inhibit the corrosion of mild steel in 0.5 M H2SO4 solution at 30°C. With the increase of temperature, the inhibition efficiency (η) of FPT at 60°C reduced to 22.62% while those of CPT and BPT under the same temperature were nearly unchanged, which were as high as 95.16% and 95.45%, resp. The adsorptions of three thiazoles on the surface of mild steel were all found to adhere to Langmuir adsorption isotherm at 30°C while only CPT and BPT obeyed at 60°C. Quantum calculations results indicated that CPT and BPT had the better adsorption ability on mild steel than FPT. Mol. dynamic stimulations were taken out to investigate the adsorption configurations of three thiazoles on the surface of Fe (0 0 1) at 30°C and 60°C, and the results implied that the binding energy of protonated BPT and CPT were nearly unchanged at studied temperatures while that of protonated FPT apparently became lower at 60°C. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Computed Properties of 2010-06-2

The Article related to halogen substituted thiazole derivative corrosion inhibitor mild steel temperature, Ferrous Metals and Alloys: Corrosion (If The Primary Interest Is In The Metal), Erosion, Cavitation, Tribology, and Oxidation and other aspects.Computed Properties of 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 27, 2003, Boyd, Scott; Caulkett, Peter William Rodney; Hargreaves, Rodney Brian; Bowker, Suzanne Saxon; James, Roger; Johnstone, Craig; Jones, Clifford David; McKerrecher, Darren; Block, Michael Howard published a patent.HPLC of Formula: 64987-16-2 The title of the patent was Preparation of benzamides affecting glucokinase for combined treatment or prevention of type 2 diabetes and obesity. And the patent contained the following:

The invention relates to the use of benzamides (shown as I; variables defined below; e.g. 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole) or a salt, solvate or prodrug thereof, in the preparation of a medicament for the treatment or prevention of a disease condition mediated through glucokinase (GLK; no data), such as type 2 diabetes, and to the compounds I and methods for preparing them. Twelve pharmaceutical compositions are included. For I: m is 0-2; n is 0-4; and n + m > 0; each R1 = OH, -(CH2)1-4OH, -CH3-aFa, -(CH2)1-44CH3-aFa, -OCH3-aFa, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, NH2, -NH-C1-4alkyl, -N-di(C1-4alkyl), CN, formyl, Ph or heterocyclyl optionally substituted by C1-6alkyl. Each R2 is the group Y-X- wherein each X is a linker = -O-Z-, -O-Z-O-Z-, -C(O)O-Z-, -OC(O)-Z-, -S-Z-, -SO-Z-, -SO2-Z-, -N(R6)-Z-, -N(R6)SO2-Z-, -SO2N(R6)-Z-, -(CH2)1-4-, -CH:CH-Z-, -CC-Z-, -N(R6)CO-Z-, -CON(R6)-Z-, -C(O)N(R6)S(O)2-Z-, -S(O)2N(R6)C(O)-Z-, -C(O)-Z-, -Z-, -C(O)-Z-O-Z-, -N(R6)-C(O)-Z-O-Z-, -O-Z-N(R6)-Z-, -O-C(O)-Z-O-Z- or a direct bond; each Z = a direct bond, C2-6alkenylene or -(CH2)p-C(R6a)2-(CH2)q-; each Y = aryl-Z1-, heterocyclyl-Z1-, C3-7cycloalkyl-Z1-, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, -(CH2)1-4CH3-aFa or -CH(OH)CH3-aFa; R3 = Ph or a heterocyclyl; addnl. details are given in the claims. More than 30 example preparations of I are included and >300 specific examples of I are included with characterization data. For example, to prepare 2-[[3,5-di(2-chlorobenzyloxy)benzoyl]amino]thiazole, diisopropylethylamine (2.0 mmol) then 4-dimethylaminopyridine (0.1 mmol) were added to a solution of 2-aminothiazole (1.0 mmol) and 3,5-di(2-chlorobenzyloxy)benzoic acid chloride (1.0 mmol) in CH2Cl2 (10 mL) under Ar at ambient temperature After 80 mins the reaction mixture was filtered, washed with CH2Cl2 and dried under high vacuum to give the title compound as a colorless solid (41%). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).HPLC of Formula: 64987-16-2

The Article related to benzamide preparation glucokinase inhibitor type 2 diabetes obesity, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 64987-16-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nazarov, V. N.; Marchenko, Ya. S.; Taran, S. V.; Ignatenko, O. N. published an article in 2006, the title of the article was Acylation of amines by diphenic anhydride.Synthetic Route of 92-36-4 And the article contains the following content:

The acylation reaction of various aliphatic, aromatic and heterocyclic amines, hydrazines and hydrazides with diphenic anhydride has been investigated. The corresponding monoamides have been exclusively obtained. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Synthetic Route of 92-36-4

The Article related to amine hydrazine hydrazine primary acylation diphenic anhydride, amide carboxybiphenyl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Synthetic Route of 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 15, 2001, Corbett, Wendy Lea; Haynes, Nancy-Ellen; Sarabu, Ramakanth published a patent.Formula: C6H8N2O2S The title of the patent was Preparation of substituted phenylacetamides and their use as glucokinase activators. And the patent contained the following:

The title compounds 4-R[(CH2)yX]zC6H4CH(CH2R1)CONHR2 [X = O, SO2; R is a ring; R1 is cycloalkyl; y and z are 0 or 1; R2 is -CONHR3 or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom], active as glucokinase activators to increase insulin secretion, were prepared E.g., 2-biphenyl-4-yl-3-cyclopentyl-N-thiazol-2-ylpropionamide was prepared by reaction of 4-biphenylacetic acid with iodomethylcyclopentane, followed by treatment with 2-aminothiazole. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S

The Article related to phenylacetamide preparation glucokinase activator, acetamide phenyl preparation glucokinase activator, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Formula: C6H8N2O2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On July 9, 2020, Maccallini, Cristina; Arias, Fabio; Gallorini, Marialucia; Amoia, Pasquale; Ammazzalorso, Alessandra; De Filippis, Barbara; Fantacuzzi, Marialuigia; Giampietro, Letizia; Cataldi, Amelia; Camacho, Maria Encarnacion; Amoroso, Rosa published an article.SDS of cas: 2010-06-2 The title of the article was Antiglioma Activity of Aryl and Amido-Aryl Acetamidine Derivatives Targeting iNOS: Synthesis and Biological Evaluation. And the article contained the following:

In the present work a set of aryl and amido-aryl acetamidine derivatives were synthesized to obtain new potent and selective inducible Nitric Oxide Synthase inhibitors with improved physicochem. parameters with respect to the previously published mols. Compound I emerged as the most promising inhibitor, and was evaluated on C6 rat glioma cell line, showing antiproliferative effects and high selectivity over astrocytes. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2

The Article related to aryl acetamidine hydrobromide preparation nitric oxide synthase inhibition sar, amidoaryl acetamidine preparation antitumor nitric oxide synthase inhibition sar, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.SDS of cas: 2010-06-2

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On November 5, 2020, Jacobsen, Eric Jon; Anderson, David Randolph; Blinn, James Robert; Mukherjee, Paramita; Changelian, Paul; Xu, Canxin published a patent.Recommanded Product: 1092942-42-1 The title of the patent was Substituted pyrrolopyridines as JAK inhibitors and their preparation and their preparation. And the patent contained the following:

The invention relates to pyrrolopyridine compounds having the structures of formula I, and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided for the treatment diseases such as pruritus, alopecia, androgenetic alopecia, alopecia areata, vitiligo and psoriasis. Compounds of formula I wherein R1 is CN and (un)substituted heteroaryl; R2 is H, (un)substituted C1-4 alkyl, (un)substituted C3-6 cycloalkyl and (un)substituted C1-2 alkyl-C3-6 cycloalkyl; Q is absent, CH2 and CH2CH2; R3 is H, halo, (un)substituted C1-4 alkyl, (un)substituted C3-6 cycloalkyl, etc.; two R3 groups may be taken together to form a spirocyclic or bicyclic ring system; R4 is COR6, CH2R5, COC1-5 alkyl and COC3-6 cycloalkyl; R6 is C1-5 alkyl, C3-6 cycloalkyl, aryl, aryloxy, etc.; and derivatives thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their JAK inhibitory activity (data given). The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Recommanded Product: 1092942-42-1

The Article related to pyrrolopyridine preparation jak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Recommanded Product: 1092942-42-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

On February 4, 2021, Anderson, David Randolph; Jacobsen, Eric Jon; Blinn, James Robert; Hockerman, Susan Landis; Mukherjee, Paramita; Changelian, Paul published a patent.Synthetic Route of 1092942-42-1 The title of the patent was Substituted sulfonamide pyrrolopyridines as JAK inhibitors and their preparation. And the patent contained the following:

The invention relates to sulfonamide pyrrolopyridine compounds of formula I and compositions useful in the treatment of JAK-mediated conditions. Methods of inhibition of JAK kinase activity in a human or animal subject are also provided. Exemplary indications treated by inhibition of JAK kinase activity include, but are not limited to, inflammatory bowel disease, Crohn’s disease, ulcerative colitis, irritable bowel syndrome, and Celiac disease. Compounds of formula I wherein R1 is CN, CO2C1-6 alkyl and (un)substituted 5- to 10-membered heteroaromatic ring; R2 and R3 are independently H, (un)substituted C1-4 alkyl and (un)substituted C0-2 alkyl-C3-6 cycloalkyl; R4 is (un)substituted C1-6 alkyl, (un)substituted C0-4 alkyl-C3-6 cycloalkyl, (un)substituted C2-5 alkyl-COC0-4 alkyl-C3-6 cycloalkyl, etc.; are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for the JAK inhibitory activity (data given). The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Synthetic Route of 1092942-42-1

The Article related to pyrrolopyridine sulfonamide preparation jak inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 1092942-42-1

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhuravel’, I. O.; Kovalenko, S. M.; Ivashchenko, A. V.; Chernykh, V. P. published an article in 2005, the title of the article was Construction of the combinatorial libraries of 5-hydroxymethyl-2-imino-8-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides.SDS of cas: 92-36-4 And the article contains the following content:

Using the parallel solution-phase synthesis combinatorial libraries of 5-hydroxymethyl-2-imino-8-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides, 5-hydroxymethyl-2-N-arylimino-methyl-2H-pyrano[2,3-c]pyridin-3-N-arylcarboxamides and their acyclic derivatives were obtained. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).SDS of cas: 92-36-4

The Article related to pyranopyridine preparation biol activity prediction, pyridoxal hydrochloride cyanoacetarylamide cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 92-36-4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica