Month: October 2022

The author of 《Synthesis of Imidazo[1,2-a]pyridines and Imidazo[2,1-b]thiazoles Attached to a Cycloalkyl or Saturated Heterocycle Containing a Tertiary Hydroxy Substitution》 were Chenna Reddy, M. L.; Patil, Vineetkumar B.; Nawaz Khan, Fazlur Rahman; Saravanan, Vadivelu. And the article was published in Journal of Heterocyclic Chemistry in 2019. Application of 3034-22-8 The author mentioned the following in the article:

A new method has been developed for the synthesis of imidazo[1,2-a]pyridines I (R = H, Me, CN, Br, OMe, etc.; R1 = R2 = H; R1R2 = CH=CH-CH=CH; RR1 = CH=CH-CH=CH; X = CH2, O, S; n = 0, 1, 2), imidazo[2,1-b]thiazoles II (R3 = H, Me, Br, Cl, COOMe; X = CH2, O, S; n = 0, 1, 2), and benzo[d]imidazo[2,1-b]thiazoles III (R4 = H, OMe, Br, F, CF3) attached to a cycloalkyl or saturated heterocycle containing a tertiary hydroxy substitution. Readily available substituted 2-aminopyridines, 2-aminothiazoles, and 2-aminobenzothiazoles were treated with bromohydroxycycloalkyl ethanones IV to afford the desired products in good yields. In the experiment, the researchers used 5-Bromothiazol-2-amine(cas: 3034-22-8Application of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Phytochemical profile and comparative anti-radical scavenging activities of n-hexane extracts of indigenous Zingiber officinale and Curcuma longa》 was written by Nweze, Chibuzo Carole; Dingwoke, Emeka John; Adamude, Fatima Amin; Nwobodo, Nwobodo Ndubuisi. Synthetic Route of C18H24N6O6S4 And the article was included in Free Radicals and Antioxidants in 2019. The article conveys some information:

Objectives: Free radical scavenging activities of n-haxane extracts of indigenous Curcuma longa and Zingiber officinale was investigated and compared to CellGevity; a nutraceutical antioxidant supplement. Methods: We used 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical, 2,2′-Azino-bis3-ethylbenzothialine-6-sulfonic acid (ABTS) radical cations and hydrogen peroxide (H2O2) to determine free radical scavenging activities of the extracts The ability of the extracts to scavenge free radicals was determined following the discoloration of the solution mixtures, measured spectrophotometrically. The reducing power efficacy of the extracts was determined by their ability to reduce Fe3+ to Fe2+ ions. Results:Curcuma longa and Zingiber officinale have more free radical scavenging power compared to CellGevity. Curcuma longa has more scavenging power against DPPH and H2O2 system, while Zingiber officinale has more scavenging power against ABTS cations. CellGevity had the least scavenging activity against the free radicals, as observed in this study. The highest phenolic, flavonoid, Vitamin C, Vitamin B1 and Vitamin B2 quantified were found in Curcuma longa and Zingiber officinale compared to CellGevity. Conclusion: The indigenous Curcuma longa and Zingiber officinale are natural sources of effective antioxidants with more scavenging power compared to a standard CellGevity nutraceutical. In the part of experimental materials, we found many familiar compounds, such as ABTS Diammonium(cas: 30931-67-0Synthetic Route of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Synthetic Route of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《Poly (urethane-urea)-epoxy glass fiber reinforced composites》 were Joshi, Medha; Desai, Dhaval; Jauhari, Smita. And the article was published in International Journal of ChemTech Research in 2021. HPLC of Formula: 95-24-9 The author mentioned the following in the article:

A series of poly(urethane-urea)s (PUU)s were synthesized using toluene 2, 4- diisocyanate, various 2-amino benzothiazoles and 3-amino phenol. All the PUUs were characterized by elemental anal., spectral studies, number average mol. weight (Mn) and thermogravimetry. Further reaction of PUUs was carried out with an epoxy resin (i.e.DGEBA). The curing study of prepared resins was monitored by DSC. Based on DSC thermograms glass fiber reinforced composites have been laminated and characterized by chem., mech. and elec. properties. The unreinforced cured resins were subjected to thermogravimetric anal. In the part of experimental materials, we found many familiar compounds, such as 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9HPLC of Formula: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.HPLC of Formula: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《The reactivity of dopamine precursors and metabolites towards ABTS·-: an experimental and theoretical study》 were Dimic, Dusan; Milenkovic, Dejan; Markovic, Zoran; Markovic, Jasmina Dimitric. And the article was published in Journal of the Serbian Chemical Society in 2019. Reference of ABTS Diammonium The author mentioned the following in the article:

The antiradical activity of L-3,4-dihydroxyphenylalanine (L-DOPA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid and tyrosine towards 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radi- cal (ABTS·-) was investigated exptl. and theor. by UV-Vis spectroscopy and the DFT theory. The importance of the catechol moiety for this reaction was proven due to the formation of intramol. hydrogen bond in the formed anions and radicals. The results indicated L-DOPA and DOPAC were more potent radical scavengers than homovanillic acid and tyrosine just because of intramol. hydrogen bond formation. Based on exptl. spectra, it was proved that electron transfer led to the reduction of ABTS·. The values of thermodn. parameters were used to predict the preferred mech- anism. The reaction rates were calculated for the electron transfer processes and it was shown that these were both kinetically and thermodynamically driven processes. Based on the reaction rate values, thermodn. para- meters, and present species, as determined by electronic spectra, it was con- cluded that single proton loss electron transfer (SPLET) is the dominant react- ion mechanism in the investigated system. After reading the article, we found that the author used ABTS Diammonium(cas: 30931-67-0Reference of ABTS Diammonium)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Reference of ABTS Diammonium

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2010,Wang, Yingcai; Jiao, Xianyun; Kayser, Frank; Liu, Jiwen; Wang, Zhongyu; Wanska, Malgorzata; Greenberg, Joanne; Weiszmann, Jennifer; Ge, Hongfei; Tian, Hui; Wong, Simon; Schwandner, Ralf; Lee, Taeweon; Li, Yang published 《The first synthetic agonists of FFA2: Discovery and SAR of phenylacetamides as allosteric modulators》.Bioorganic & Medicinal Chemistry Letters published the findings.Reference of 5-Bromothiazol-2-amine The information in the text is summarized as follows:

Free fatty acid receptor 2 (FFA2) is a G-protein coupled receptor for which only short-chain fatty acids (SCFAs) have been reported as endogenous ligands. We describe the discovery and optimization of phenylacetamides as allosteric agonists of FFA2. These novel ligands can suppress adipocyte lipolysis in vitro and reduce plasma FFA levels in vivo, suggesting that these allosteric modulators can serve as pharmacol. tools for exploring the potential function of FFA2 in various disease conditions. In addition to this study using 5-Bromothiazol-2-amine, there are many other studies that have used 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine) was used in this study.

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

In 2011,Andreani, Aldo; Granaiola, Massimiliano; Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella; Varoli, Lucilla; Lannigan, Deborah; Smith, Jeff; Scudiero, Dominic; Kondapaka, Sudhir; Shoemaker, Robert H. published 《Imidazo[2,1-b]thiazole guanidinylhydrazones as RSK2 inhibitors》.European Journal of Medicinal Chemistry published the findings.Product Details of 3034-22-8 The information in the text is summarized as follows:

The activity of a series of imidazo[2,1-b]thiazole guanidinylhydrazones as inhibitors of p90 ribosomal S6 kinase 2 (RSK2) is described. It was found that a small subset of compounds show both potent inhibition of RSK2 kinase activity and tumor cell growth in vitro. Detailed study of one of the most active compounds indicates a high degree of selectivity for inhibition of RSK2 compared to a spectrum of other related kinases. Selective inhibition of the MCF-7 breast tumor cell line compared to MCF-10A non-transformed cells, as well as selective inhibition of the biomarker GSK3 provides evidence that the compounds can affect the RSK2 target in cells. In the part of experimental materials, we found many familiar compounds, such as 5-Bromothiazol-2-amine(cas: 3034-22-8Product Details of 3034-22-8)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Product Details of 3034-22-8

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

The author of 《4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching》 were Leoni, Alberto; Frosini, Maria; Locatelli, Alessandra; Micucci, Matteo; Carotenuto, Claudio; Durante, Miriam; Cosconati, Sandro; Budriesi, Roberta. And the article was published in European Journal of Medicinal Chemistry in 2019. Reference of 5-Bromothiazol-2-amine The author mentioned the following in the article:

Synthesis, characterization and evaluation of neuroprotective effects of a focused library of 4-imidazo[2,1-b]thiazole-1,4-dihydropyridines I [R = 2-FC6H4, 4-ClC6H4, 4-O2NC6H4, etc.; R1 = Me, Et, H2C=CHCH2; R2 = H, Me, Et, F, Cl, Br; R3 = H, Me]. Furthermore, the dihydropyridines were subjected to functional in vitro assays in cardiac tissues and vascular smooth muscle to determine their possible selectivity in counteracting the effects of neurodegeneration. In particular the strategy adopted for designing the compounds involved the imidazo[2,1-b]thiazole nucleus. The observed properties showed that substituents at C2 and C6 of the bicyclic scaffold were able to influence the cardiovascular parameters and the neuroprotective activity. In comparison to nifedipine, a set of derivatives such as compound I [R = CF3; R1 = Me; R2 = Me; R3 = H], showed a neuroprotective profile of particular interest. The experimental process involved the reaction of 5-Bromothiazol-2-amine(cas: 3034-22-8Reference of 5-Bromothiazol-2-amine)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 5-Bromothiazol-2-amine

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Formula: C3H3BrN2SIn 2012 ,《Microwave-promoted synthesis and antimicrobial activity of 3-thiazole substituted 2-styryl-4(3H)-quinazolinone derivatives》 was published in Journal of Saudi Chemical Society. The article was written by Jagani, Chandresh L.; Sojitra, Natvar A.; Vanparia, Satish F.; Patel, Tarosh S.; Dixit, Ritu B.; Dixit, Bharat C.. The article contains the following contents:

The present paper described an optimized reaction condition for the microwave-promoted synthesis of newer 3-thiazole-substituted 2-styryl-4(3H)-quinazolinone derivatives, which in turn were prepared in good yield by the treatment of various 2-styrylbenzoxazinone derivatives with various 2-aminothiazoles using co-solvent under microwave irradiation All the compounds were characterized by various spectroscopic techniques and anal. methods. All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus megaterium, Bacillus subtilis, and Aspergillus niger. In the experimental materials used by the author, we found 5-Bromothiazol-2-amine(cas: 3034-22-8Formula: C3H3BrN2S)

5-Bromothiazol-2-amine(cas: 3034-22-8) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Formula: C3H3BrN2S

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

《Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide》 was published in Chemistry – A European Journal in 2018. These research results belong to Mukhopadhyay, Sushobhan; Batra, Sanjay. Synthetic Route of C7H3BrClNS The article mentions the following:

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimides (NXS) in DMF at room temperature under metal- and acid-free condition was described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide. In the experimental materials used by the author, we found 2-Bromo-4-chlorobenzo[d]thiazole(cas: 3622-40-0Synthetic Route of C7H3BrClNS)

2-Bromo-4-chlorobenzo[d]thiazole(cas: 3622-40-0) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.Synthetic Route of C7H3BrClNSTheir presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Formula: C18H24N6O6S4On June 8, 2022, Chalmpes, Nikolaos; Patila, Michaela; Kouloumpis, Antonios; Alatzoglou, Christina; Spyrou, Konstantinos; Subrati, Mohammed; Polydera, Angeliki C.; Bourlinos, Athanasios B.; Stamatis, Haralambos; Gournis, Dimitrios published an article in ACS Applied Materials & Interfaces. The article was 《Graphene oxide-cytochrome C multilayered structures for biocatalytic applications: Role of surfactant in Langmuir-Schaefer layer deposition》. The article mentions the following:

Graphene, a two-dimensional single-layer carbon allotrope, has attracted tremendous scientific interest due to its outstanding physicochem. properties. Its monat. thickness, high sp. surface area, and chem. stability render it an ideal building block for the development of well-ordered layered nanostructures with tailored properties. Herein, biohybrid graphene-based layer-by-layer structures are prepared by means of conventional and surfactant-assisted Langmuir-Schaefer layer deposition techniques, whereby cytochrome C mols. are accommodated within ordered layers of graphene oxide. The biocatalytic activity of the as-developed nanobio-architectures toward the enzymic oxidation of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt and decolorization of pinacyanol chloride is tested. The results show that the multilayer structures exhibit high biocatalytic activity and stability in the absence of surfactant mols. during the deposition of the monolayers. In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0Formula: C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Formula: C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica