Month: October 2022

Pawde, A. V.’s team published research in European Journal of Biomedical and Pharmaceutical Sciences in 2021 | CAS: 95-24-9

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

The author of 《Synthesis and biological evaluation of some newly synthesized thiazolo-pyrimido-pyrimidobenzothiazoles》 were Pawde, A. V.; Kadam, D. B.; Vartale, S. P.. And the article was published in European Journal of Biomedical and Pharmaceutical Sciences in 2021. SDS of cas: 95-24-9 The author mentioned the following in the article:

Condensation of 2-amino-5-methylthiazole with bis(methylthio)methylene malononitrile give 6-cyano-5-imino-2-methyl-7-(methylthio)-5H-thiazolo[3,2-a]pyrimidine. Which on further condensation with various 2-amino-substituted benzothiazoles yield 12, 13-diimino-9-methyl- thiazolo[2,3-a]-4H-pyrimido[4,5-d]-4H-pyrimido[2,1-b]benzothiazoles I (R1 = H, Cl; R2 = H, Me, OMe, F, Cl, NO2; R3 = H, Me). Some of the newly synthesized compounds have been screened for their antimicrobial and antioxidant activity. In the experiment, the researchers used many compounds, for example, 6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9SDS of cas: 95-24-9)

6-Chlorobenzothiazol-2-ylamine(cas: 95-24-9) belongs to thiazoles. Thiazoles are a class of five-membered rings containing nitrogen and sulfur with excellent antitumor, antiviral and antibiotic activities.SDS of cas: 95-24-9Their presence in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Vikram, V.’s team published research in International Journal of Pharmaceutical Sciences and Research in 2021 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C18H24N6O6S4

In 2021,International Journal of Pharmaceutical Sciences and Research included an article by Vikram, V.; Kishore, P. Ram; Kalaiyarasan, A.; Hariram, N.. Computed Properties of C18H24N6O6S4. The article was titled 《Protein profiling and isolation of bioactive hydrolysates with antioxidant activity from stem callus tissue of tinospora cordifolia (willd.) miers exposed to cyclodextrin》. The information in the text is summarized as follows:

This study is aimed to evaluate the effects of different concentrations of cyclodextrin, an auxin stabilizing agent, on callus growth from the stem explants of Tinospora cordifolia and to assess the antioxidant properties of the bioactive hydrolyzates of callus tissue using chymotrypsin, trypsin, pepsin, and papain. Cyclodextrin exerted a dose- and time-dependent effect on the callus growth. α-Chymotrypsin hydrolyzate showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging, while trypsin hydrolyzate exhibited the highest 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) activity. Protein profiling of callus tissue revealed a few tissue-specific bands at 41, 30, 20, and 9 kDa with varying intensities. A growth medium containing sucrose has a specific impact on the expression of these polypeptides. Purification of 30 kDa polypeptide by Sephadex-G50 revealed distinct quant. differences to different concentrations of cyclodextrin. This study suggested that T.cordifolia callus tissue protein hydrolyzates exhibited antioxidant efficacy, leading to the development of a nutraceutical agent in promoting health. The experimental process involved the reaction of ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fonseca, Laura Martins’s team published research in International Journal of Biological Macromolecules in 2019 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C18H24N6O6S4

Synthetic Route of C18H24N6O6S4On October 15, 2019 ,《Development of antimicrobial and antioxidant electrospun soluble potato starch nanofibers loaded with carvacrol》 was published in International Journal of Biological Macromolecules. The article was written by Fonseca, Laura Martins; Cruxen, Claudio Eduardo dos Santos; Bruni, Graziella Pinheiro; Fiorentini, Angela Maria; Zavareze, Elessandra da Rosa; Lim, Loong-Tak; Dias, Alvaro Renato Guerra. The article contains the following contents:

In this study, a method was developed to encapsulated carvacrol in nanofibers from soluble potato starch. The carvacrol was added in starch solutions at various concentrations (0, 20, 30 and 40% volume/volume) and electrospun into fibers. The morphol., size distribution, thermal stability, FT-IR spectra, relative crystallinity (RC) and antioxidant of the electrospun fibers were analyzed. For mech. properties and antimicrobial activities evaluation electrospun nonwovens were obtain. The carvacrol-loaded nanofibers showed homogeneous morphol. and average diameters ranging from 73 to 95 nm. The carvacrol encapsulated in the nanofibers had greater thermal stability than the free carvacrol. FT-IR anal. showed interactions between starch and carvacrol. The RC of the nanofibers was approx. 40%. The electrospun nonwovens mech. properties did not present significant differences (p < 0.05). The 40% carvacrol-loaded nanofibers exhibited higher antioxidant activity with 83.1% of inhibition. The electrospun nonwoven loaded with 30% carvacrol resulted in 89.0% reduction of Listeria monocytogenes, 68.0% for Salmonella Typhimurium, 62.0% for Escherichia coli and 49.0% for Staphylococcus aureus. These electrospun nonwovens sustained antimicrobial activity for at least 30 days against S. aureus. The starch nanofibers are promising materials for application as a vehicle for carvacrol release in antimicrobial and antioxidant food packages. In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0Synthetic Route of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Godocikova, Lucia’s team published research in Journal of Food and Nutrition Research (Bratislava, Slovakia) in 2019 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 30931-67-0

In 2019,Journal of Food and Nutrition Research (Bratislava, Slovakia) included an article by Godocikova, Lucia; Ivanisova, Eva; Noguera-Artiaga, Luis; Carbonell-Barrachina, Angel A.; Kacaniova, Miroslava. SDS of cas: 30931-67-0. The article was titled 《Biological activity, antioxidant capacity and volatile profile of enriched Slovak chocolates》. The information in the text is summarized as follows:

Different kinds and types of chocolates produced in Slovakia with various fruit and nut enrichments were analyzed regarding total polyphenols, flavonoids and phenolic acids contents using spectrophotometric methods and their volatile profile was analyzed using gas chromatog.-mass spectrometry. The method with 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferric reducing power method (FRAP) were used to measure antioxidant activity. Plain dark chocolate without any enrichment made by a traditional process contained the highest number of total polyphenols and phenolic acids and also had the highest antioxidant activity. Pos. correlation was observed between antioxidant activity and total contents of phenolic compounds, flavonoids and phenolic acids. The enrichment with different kinds of fruits did not increase the number of bioactive compounds or antioxidant capacity of chocolates but created more attractive sensory profiles due to the presence of new volatile compounds In the experimental materials used by the author, we found ABTS Diammonium(cas: 30931-67-0SDS of cas: 30931-67-0)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.SDS of cas: 30931-67-0

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ji, Feixiang’s team published research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021 | CAS: 30931-67-0

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C18H24N6O6S4

Computed Properties of C18H24N6O6S4On May 15, 2021 ,《Excited state electronic structures and photochemistry of different oxidation states of 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)》 appeared in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. The author of the article were Ji, Feixiang; Guo, Yurong; Wang, Mengqi; Wu, Zibo; Shi, Yanan; Zhao, Xiaoying; Wang, Haiyuan; Feng, Xia; Zhao, Guangjiu. The article conveys some information:

The mol. structures of 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), were calculated by using time-dependent d. functional theory (TDDFT) model with M062X method with 6-311G (d, p) basis set. In this work, the ABTS were theor. investigated from the geometric structure, the energy levels of the LUMO (LUMO) and the HOMO (HOMO), the energy level gap ΔEHOMO-LUMO of the mol. ground state, excited stated properties and the electronic absorption spectra of different oxidation states. We studied the energy levels of LUMO and HOMO of ABTS in different oxidation states. Frontier MO anal. can provide insight into the nature of excited states. ABTS was synthesized from N-ethylaniline by total synthesis. Then, we measured the UV-Vis spectra of ABTS before and after being oxidized by K2S2O8. The calculated electronic structures and photochem. properties of different oxidation state of ABTS were in accordance with the exptl. result. This work demonstrates the relationship between the electronic structures and photochem. of different oxidation states ABTS hence paves the way for the rationally synthesis and deepen understanding of the photophys. properties of ABTS materials. After reading the article, we found that the author used ABTS Diammonium(cas: 30931-67-0Computed Properties of C18H24N6O6S4)

ABTS Diammonium(cas: 30931-67-0) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C18H24N6O6S4

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Ulmschneider, Sarah’s team published research in Journal of Medicinal Chemistry in 2005-03-10 | 1003-32-3

Journal of Medicinal Chemistry published new progress about Homo sapiens. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Synthetic Route of 1003-32-3.

Ulmschneider, Sarah; Mueller-Vieira, Ursula; Klein, Christian D.; Antes, Iris; Lengauer, Thomas; Hartmann, Rolf W. published the artcile< Synthesis and Evaluation of (Pyridylmethylene)tetrahydronaphthalenes/-indanes and Structurally Modified Derivatives: Potent and Selective Inhibitors of Aldosterone Synthase>, Synthetic Route of 1003-32-3, the main research area is heteroarylidene aromatic compound stereoisomer preparation aldosterone oxidase inhibition; pyridylmethylene tetrahydronaphthalene indane stereoisomer preparation aldosterone oxidase inhibition; structure heteroarylidene aromatic compound stereoisomer aldosterone oxidase inhibition; CYP11B2 inhibiting heteroarylidene aromatic compound stereoisomer preparation; selective aldosterone oxidase inhibiting heteroarylidene aromatic compound; mol modeling heteroarylidene aromatic compound binding CYP11B1 CYP11B2.

Heteroarylmethylidene-substituted aromatic compounds such as heteroarylmethyleneindanes I (X = CH, N) are prepared as selective inhibitors of aldosterone synthase (CYP11B2) in the presence of related enzymes such as steroid 11β-hydroxylase (CYP11B1), CYP17, and CYP19. Substituted aromatic ketones, particularly substituted 1-indanones, are reduced with sodium borohydride; substitution of the aromatic alcs. with triphenylphosphine hydrobromide, and Wittig olefination of heterocyclic aldehydes with the generated triphenylphosphonium bromides yields heteroarylmethylene-substituted aromatic compounds such as I (X = CH, N). Both the (E) and the (Z) olefin stereoisomers of many of the heteroarylmethylene-substituted aromatic compounds are prepared Pyridinylmethyleneindane I (X = CH) is the most active inhibitor of CYP11B2 tested, with an IC50 value of 7 nM; pyrimidinylmethyleneindane I (X = N) is the most selective CYP11B2 inhibitor of those tested, with IC50 values of 27 nM for CYP11B2 and 3179 nM for CYP11B1. Mol. modeling of selected compounds and of their complexes with CYP11B1 and CYP11B2 is used to understand the dependence of CYP11B2 inhibition and selectivity on inhibitor structure.

Journal of Medicinal Chemistry published new progress about Homo sapiens. 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Synthetic Route of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Fagundez, Catherine’s team published research in Heterocyclic Letters in 2013 | 96929-05-4

Heterocyclic Letters published new progress about 96929-05-4. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Formula: C12H18N2O4S.

Fagundez, Catherine; Serra, Gloria published the artcile< Studies on synthesis of amino acid derived thiazoles. Preparation of bis-thiazoles as key fragments of aerucyclamide analogs>, Formula: C12H18N2O4S, the main research area is thiazole bisthiazole preparation.

The scope and limitations of Hantzsch, modified Hantzsch and Kelly methodologies for the synthesis of amino acid derived thiazoles are presented. In addition, the syntheses of bisthiazoles as key fragments of natural products and analogs are described. The Kelly’s methodol. followed by oxidation provides the desired N-Cbz protected thiazole after purification According with the authors’ results the Fmoc or Boc protecting groups are not compatible with the conditions used in this methodol. Modifications of the temperature and reagents used in the Hantzsch thiazole synthesis enabled the preparation of chiral thiazole building blocks without racemization and in good yields.

Heterocyclic Letters published new progress about 96929-05-4. 96929-05-4 belongs to class thiazole, and the molecular formula is C12H18N2O4S, Formula: C12H18N2O4S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kennington, Stuart C D’s team published research in Organic Letters in 2019-01-04 | 96-53-7

Organic Letters published new progress about C-C bond formation (enantioselective). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Kennington, Stuart C. D.; Taylor, Adam J.; Romea, Pedro; Urpi, Felix; Aullon, Gabriel; Font-Bardia, Merce; Ferre, Laura; Rodrigalvarez, Jesus published the artcile< Direct and Asymmetric Nickel(II)-Catalyzed Construction of Carbon-Carbon Bonds from N-Acyl Thiazinanethiones>, Electric Literature of 96-53-7, the main research area is asym nickel catalyzed carbon bond acyl thiazinanethione; peperomin D total synthesis; dimethoxyphenyl methylphenylethyl propanamide preparation crystal mol structure.

A wide array of new N-acyl thiazinanethiones are employed in a number of direct and enantioselective carbon-carbon-bond-forming reactions catalyzed by nickel(II) complexes. The electrophilic species are mostly prepared in situ from ortho esters, Me ethers, acetals, and ketals, which makes the overall process highly efficient and exptl. straightforward. Theor. calculations indicate that the reactions proceed through an open transition state in a SN1-like mechanism. The utility of this novel procedure has been demonstrated by the asym. preparation of synthetically useful intermediates and the total synthesis of peperomin D.

Organic Letters published new progress about C-C bond formation (enantioselective). 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, Electric Literature of 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Kottawar, S S’s team published research in E-Journal of Chemistry in 2011 | 57493-24-0

E-Journal of Chemistry published new progress about Aldimines Role: SPN (Synthetic Preparation), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Kottawar, S. S.; Goswami, S. V.; Thorat, P. B.; Bhusare, S. R. published the artcile< L-Proline as an efficient catalyst for synthesis of aldimines at ambient temperature condition>, Electric Literature of 57493-24-0, the main research area is thiazolamine aromatic aldehyde condensation proline catalyst; aldimine green preparation.

Some new aldimines were synthesized from substituted 2-aminothiazoles and different aromatic aldehydes using L-proline as an efficient catalyst. Easy work up, higher yields, and shorter reaction time are the advantages of the method.

E-Journal of Chemistry published new progress about Aldimines Role: SPN (Synthetic Preparation), PREP (Preparation). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Electric Literature of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nguyen, William’s team published research in Journal of Medicinal Chemistry in 2019-05-23 | 101080-15-3

Journal of Medicinal Chemistry published new progress about Anti-HIV agents. 101080-15-3 belongs to class thiazole, and the molecular formula is C6H10N2S, COA of Formula: C6H10N2S.

Nguyen, William; Jacobson, Jonathan; Jarman, Kate E.; Jousset Sabroux, Helene; Harty, Leigh; McMahon, James; Lewin, Sharon R.; Purcell, Damian F.; Sleebs, Brad E. published the artcile< Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models>, COA of Formula: C6H10N2S, the main research area is acylaminothiazole TAT transcription HIV1 latency antiretroviral agent HIV infection.

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

Journal of Medicinal Chemistry published new progress about Anti-HIV agents. 101080-15-3 belongs to class thiazole, and the molecular formula is C6H10N2S, COA of Formula: C6H10N2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica