Month: October 2022

Hoseinzadeh, A. R.; Javadpour, S. published the artcile< Electrochemical, thermodynamic and theoretical study on anticorrosion performance of a novel organic corrosion inhibitor in 3.5% NaCl solution for carbon steel>, SDS of cas: 96-53-7, the main research area is carbon steel sodium chloride corrosion inhibitor electrochem anticorrosion property.

The theor. and electrochem. performance of a novel organic corrosion inhibitor 3,4-dihydro-3-[2-mercaptothiazolidine]indol-2-one (DMI), for API 5L Grade B carbon steel in 3.5% NaCl, was evaluated by potentiodynamic polarization (Tafel), electrochem. impedance spectroscopy (EIS) and d. functional theory (DFT) for quantum chem. studies. Potentiodynamic studies confirmed that DMI was a mixed organic corrosion inhibitor type which specially affects the cathodic branch. The inhibition efficiencies of reactants, DMI and acetylcysteine followed the following order at 25oC and 200 ppm: DMI (87%) > isatin (71%) > 2-thiazoline-2-thiol (62%) > acetylcysteine (54%). EIS measurements illustrated the charge transfer controlled corrosion process. The Langmuir adsorption isotherm model of DMI was adopted. Surface studies were performed using SEM. Activation and adsorption thermodn. parameters of DMI were computed. The magnitude of ΔGoads and the sign of ΔHoads concluded that the adsorption occurred through chemisorption. Quantum chem. calculations of four corrosion inhibitors were used for investigating the mol. structure effect on inhibition efficiency.

Bulletin of Materials Science published new progress about Adsorption. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, SDS of cas: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Peixoto, Philippe A.; Richard, Jean-Alexandre; Severin, Rene; Chen, David Y.-K. published the artcile< Total Synthesis of Echinopines A and B: Exploiting a Bioinspired Late-Stage Intramolecular Cyclopropanation>, Related Products of 171877-39-7, the main research area is echinopine A B synthesis intramol cyclopropanation.

Total synthesis of echinopine A and B have been accomplished, based on a strategy that involved two transition-metal-mediated ene-yne cycloisomerizations. A modified Pd-catalyzed enyne cycloisomerization/intramol. Diels-Alder cascade rendered a more streamlined synthesis of tricyclic ketone I, and a Ru-catalyzed ene-yne cycloisomerization/cyclopropanation resembled the late-stage [5/7] → [3/5/5/7] ring-forming sequence in the proposed biosynthetic pathway.

Organic Letters published new progress about Cycloisomerization. 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Related Products of 171877-39-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Patel, Vimal I.; Patel, Harsha U.; Patel, Chhaganbhai N.; Suthar, Kiran J. published the artcile< Synthesis and anti-bacterial study of 4-(4-substituted phenyl)-5,6-disubstituted-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-one>, Reference of 57493-24-0, the main research area is pyridinone arylthiazolyl preparation antibacterial.

4-(4-Substituted phenyl)-5,6-disubstituted-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-ones have been prepared from citric acid. It is treated with concentrate H2SO4 and then with phenetole to give β-arylglutaconic acid which on fusion with 2-amino 4-substituted phenylthiazole gave 4-(substituted phenyl)-1-1(4-substituted phenylthiazol-2-yl)pyridine-2,6(1H,3H)-dione. Then reaction with phosphorus oxychloride gave 5,6-dichloro-4-(4-substituted phenyl)-1-(4-substituted phenylthiazol-2-yl)pyridin-2(1H)-one. This, on treatment with secondary amines, yields 4-(4-substituted phenyl)-5,6-disubstituted-1-(4-substituted-phenylthiazol-2-yl)pyridin-2(1H)-one. All the title compounds characterized on the basis of their IR, MASS, 1H NMR spectroscopic data anal.

Asian Journal of Research in Chemistry published new progress about Antibacterial agents. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Reference of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Wang, Yixuan; Chen, Quan; Wu, Di; Chen, Qifeng; Gong, Guanghui; He, Liuqing; Wu, Xiaoying published the artcile< Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells>, Category: thiazole, the main research area is laminA protein Hsp DNA damage chemoresistance ovarian cancer cell.

Ovarian cancer is the most malignant gynecol. cancer. Previous studies found that lamin-A was associated with DNA damage repair proteins but the underlying mechanism remains unclear. We speculate that this may be related to its interacting proteins, such as Hsp90. The aim of this study is to investigate the effects of Hsp90 on DNA damage repair and chemoresistance of ovarian cancer cells. In our research, co-immunoprecipitation (co-IP) and mass spectrometry (MS) were used to identify proteins interacting with lamin-A and the interaction domain. Next, the relationship between lamin-A and Hsp90 was explored by Western blotting (WB) and immunofluorescence staining. Then, effect of Hsp90 inhibition on DNA damage repair was assessed through detecting Rad50 and Ku80 by WB. Furthermore, to test the roles of 17-AAG on cell chemosensitivity, CCK-8 and colony formation assay were carried out. Meanwhile, IC50 of cells were calculated, followed by immunofluorescence to detect DNA damage. At last, the mouse xenograft model was used in determining the capacity of 17-AAG and DDP to suppress tumor growth and metastatic potential. The results showed that lamin-A could interact with Hsp90 via the domain of lamin-A1-430. Besides, the distribution of Hsp90 could be affected by lamin-A. After lamin-A knockdown, Hsp90 decreased in the cytoplasm and increased in the nucleus, suggesting that the interaction between lamin-A and Hsp90 may be related to the nucleocytoplasmic transport of Hsp90. Moreover, inhibition of Hsp90 led to an obvious decrease in the expression of DSBs (DNA double-strand break) repair proteins, as well as cell proliferation ability upon DDP treatment and IC50 of DDP, causing more serious DNA damage. In addition, the combination of 17-AAG and DDP restrained the growth of ovarian cancer efficiently in vivo and prolonged the survival time of tumor-bearing mice.

Cell Death & Disease published new progress about Antitumor agents. 2591-17-5 belongs to class thiazole, and the molecular formula is C11H8N2O3S2, Category: thiazole.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Pola, Robert; Kral, Vlastimil; Filippov, Sergey K.; Kaberov, Leonid; Etrych, Tomas; Sieglova, Irena; Sedlacek, Juraj; Fabry, Milan; Pechar, Michal published the artcile< Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells>, SDS of cas: 96-53-7, the main research area is polymer tumor targeting antibody ganglioside GD2.

A water-soluble polymer cancerostatic actively targeted against cancer cells expressing a disialoganglioside antigen GD2 was designed, synthesized and characterized. A polymer conjugate of an antitumor drug doxorubicin with a N-(2-hydroxypropyl)methacrylamide-based copolymer was specifically targeted against GD2 antigen-pos. tumor cells using a recombinant single chain fragment (scFv) of an anti-GD2 monoclonal antibody. The targeting protein ligand was attached to the polymer-drug conjugate either via a covalent bond between the amino groups of the protein using a traditional nonspecific aminolytic reaction with a reactive polymer precursor or via a noncovalent but highly specific interaction between bungarotoxin covalently linked to the polymer and the recombinant scFv modified with a C-terminal bungarotoxin-binding peptide. The GD2 antigen binding activity and GD2-specific cytotoxicity of the targeted noncovalent polymer-scFv complex proved to be superior to the covalent polymer-scFv conjugate.

Biomacromolecules published new progress about Antibody-drug conjugates. 96-53-7 belongs to class thiazole, and the molecular formula is C3H5NS2, SDS of cas: 96-53-7.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Zhang, Xiaoyu; Luukkonen, Lena M.; Eissler, Christie L.; Crowley, Vincent M.; Yamashita, Yu; Schafroth, Michael A.; Kikuchi, Shota; Weinstein, David S.; Symons, Kent T.; Nordin, Brian E.; Rodriguez, Joe L.; Wucherpfennig, Thomas G.; Bauer, Ludwig G.; Dix, Melissa M.; Stamos, Dean; Kinsella, Todd M.; Simon, Gabriel M.; Baltgalvis, Kristen A.; Cravatt, Benjamin F. published the artcile< DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras>, HPLC of Formula: 1003-32-3, the main research area is DCAF11 targeted protein degradation electrophilic PROTAC cancer.

Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have been found to support ligand-induced protein degradation, reflecting a dearth of E3-binding compounds for proteolysis-targeting chimera (PROTAC) design. Here, we describe a functional screening strategy performed with a focused library of candidate electrophilic PROTACs to discover bifunctional compounds that degrade proteins in human cells by covalently engaging E3 ligases. Mechanistic studies revealed that the electrophilic PROTACs act through modifying specific cysteines in DCAF11, a poorly characterized E3 ligase substrate adaptor. We further show that DCAF11-directed electrophilic PROTACs can degrade multiple endogenous proteins, including FBKP12 and the androgen receptor, in human prostate cancer cells. Our findings designate DCAF11 as an E3 ligase capable of supporting ligand-induced protein degradation via electrophilic PROTACs.

Journal of the American Chemical Society published new progress about Androgen receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, HPLC of Formula: 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Bumbu, Valentina D.; Yang, Xing; Birman, Vladimir B. published the artcile< Kinetic Resolution of N-Acyl-Thiolactams via Catalytic Enantioselective Deacylation>, Application of C10H11NS2, the main research area is kinetic resolution acyl thiolactam catalytic enantioselective deacylation benzotetramisole.

Methanolysis of N-acylthiazolidin-2-thiones and -oxazolidin-2-thiones in the presence of acyl transfer catalyst benzotetramisole (BTM) proceeds in a highly enantioselective fashion thus enabling kinetic resolution of these substrates [e.g., treatment of thiolactam (±)-I with MeOH, catalyst II and PhCO2H afforded (S)-III + (R)-I with s = 84].

Organic Letters published new progress about Acylation catalysts (stereoselective). 171877-39-7 belongs to class thiazole, and the molecular formula is C10H11NS2, Application of C10H11NS2.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Nizamuddin, N. D.; Abdul Ahad, Hindustan; Devanna, Nayakanti published the artcile< Synthesis and molecular docking studies of some 1,2-dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydroquinazolin-4(1H)-ones as anticancer agents>, Synthetic Route of 57493-24-0, the main research area is dimethyl phenyl thiazolyl dihydroquinazolinone preparation mol docking.

Synthesis of 1, 2-dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydro quinazolin-4(1H)-ones derivatives I [R = 4-Me, 2-OH, 4-Cl, etc.] was effected by refluxing 1,2-dimethylbenzoxazine-4-one with different 4-substituted phenyl-1,3-thiazol-2-amines. Synthesized compoundsI were characterized through elemental anal., IR, proton NMR, and Carbon-13 NMR. Mol. docking studies were carried out using Schrodinger Glide (version 2020_1) which was docked into selective P38alpha and Activin A Receptor Type 1 (ACVR1) Activin receptor-like kinase-2 (ALK2) kinase with Protein Data Bank (PDB) code 3GC7, 6GI6. Based on the docking score of synthesized quinazolin-4-one derivatives, I co-crystallized ligands interaction was evaluated with 5-fluorouracil (5-FU) as a reference drug. Compounds I [R = H, 4-MeO, 3-NH2, 2,4-OH] with P38alpha, I [R = 2-OH, 3-NH2, 4-Cl, 2,4-OH] with ACVR1 (ALK2) kinase score were -7.265, -7.078, -7.058 and -6.836; -8.929, -8.749, -8.735 and -8.464 Kcal/mol against enzymes responsible for cancer treatment. The results indicated that quinazolin-4-one derivatives I scored better than ligand and 5-FU.

Indian Journal of Heterocyclic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, Synthetic Route of 57493-24-0.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Lakhan, Ram; Singh, Om Prakash published the artcile< Local anesthetics. Part-III: synthesis of 2-(N-substituted or N,N-disubstituted aminoacetamido)-4 arylthiazoles>, COA of Formula: C9H7N3O2S, the main research area is aminoacetamidothiazole aryl local anesthetic preparation; phenylthiazole aminoacetamido local anesthetic preparation.

Title compounds I [R = 4-O2NC6H4, 3-O2NC6H4, 2,5-(MeO)2C6H3; R1 = Et, Me2CH, Me2CHCH2, MeEtCH; R2 = H, Et; R1R2 = piperidino] were prepared E.g., cyclocondensation of 4-O2NC6H4COMe with thiourea gave thiazole II, chloroacetylation of which followed by amination with EtNH2 gave I (R = 4-O2NC6H4, R1 = Et, R2 = H). I HCl (R = 3-O2NC6H4, R1 = MeEtCH, R2 = H) showed local anesthetic activity superior to that of procaine HCl.

Journal of the Indian Chemical Society published new progress about Local anesthetics. 57493-24-0 belongs to class thiazole, and the molecular formula is C9H7N3O2S, COA of Formula: C9H7N3O2S.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica

Jiang, Xingyu; Hartwig, John F. published the artcile< Iridium-Catalyzed Enantioselective Allylic Substitution of Aliphatic Esters with Silyl Ketene Acetals as the Ester Enolates>, Related Products of 1003-32-3, the main research area is homoallylic ester regioselective diastereoselective enantioselective preparation; ester aliphatic silyl ketene acetal regioselective enantioselective allylic substitution; alkylation; asymmetric catalysis; enantioselectivity; esters; iridium.

An iridium-catalyzed enantioselective allylic substitution of aliphatic esters (E)-R1CH:CHCH2OC(O)Ph (R1 = Ph, 4-MeC6H4, 2-thienyl, 3-pyridyl, etc.) with silyl ketene acetals R22C:C(OR3)SiMe3 [R2 = Me, Et; R22 = (CH2)3, (CH2)5, (CH2)2O(CH2)2, etc.; R3 = Me, i-Pr, t-Bu, Ph, etc.] to form products containing a quaternary carbon atom at the nucleophile moiety and a tertiary carbon atom at the electrophile moiety is reported. Under relatively neutral conditions, the allylated aliphatic esters H2C:CHCH(R1)CR22CO2R3 were obtained with excellent regio- and enantioselectivity. These products were readily converted into primary alcs., carboxylic acids, amides, isocyanates, and carbamates, as well as THF and γ-butyrolactone derivatives, without erosion of enantiomeric purity.

Angewandte Chemie, International Edition published new progress about Acetals, ketene, silyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1003-32-3 belongs to class thiazole, and the molecular formula is C4H3NOS, Related Products of 1003-32-3.

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica