On October 18, 2012, Holcomb, Ryan C.; Sebahar, Paul R.; Suzuki, Kazuyuki; McLeod, Donald A.; Dastrup, David M.; Hoarau, Christophe; Halter, Robert J.; Bursavich, Matthew Gregory; Shenderovich, Mark D.; Richards, Burt; Bartel, Paul L. published a patent.Product Details of 64987-16-2 The title of the patent was Preparation of substituted pyrimidinylbenzonitriles as IKK-related kinase ε and TANK-binding kinase 1 inhibitors. And the patent contained the following:
The invention relates to compounds I [R1 = (un)substituted heteroaryl, heterocyclyl, heteroarylalkylene, etc.; R2 = alkyl, cycloalkyl, aryl, etc.; R3-R7 = alkyl, cycloalkyl, aryl, etc.; with the provisos], pharmaceutical compositions and medicaments comprising such compounds, and the use of these compounds, compositions, and medicaments in methods of treating diseases and disorders. Two-hundred-fifty-three compounds I were prepared E.g., a multi-step synthesis of II, starting from 5-bromo-2-hydroxybenzonitrile and tetrahydro-2H-pyran-4-ol, was described. Exemplified compounds I were tested in in vitro IKKε and TBK1 kinase assays (data given). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Product Details of 64987-16-2
The Article related to pyrimidinylbenzonitrile preparation ikk epsilon tbk1 kinase inhibitor, pyrimidinyl benzonitrile preparation tank binding kinase 1 inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica