On January 16, 2014, Jana, Gourhari; Kurhade, Sanjay Pralhad; Jagdale, Arun Rangnath; Kukreja, Gagan; Sinha, Neelima; Palle, Venkata P.; Kamboj, Rajender Kumar published a patent.Application of 1092942-42-1 The title of the patent was Preparation of tetrahydroquinazolinone derivatives as PARP inhibitors for treating cancer. And the patent contained the following:
Disclosed are compounds of formula I, their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, (wherein M is C, CH, and N, and the dotted bond is either a single or double bond with provisos; R1 is H and (un)substituted alkyl; R2 and R3 together with the carbon atom(s) to which they are attached form a (un)substituted carbocycle; each R4 is halogen, cyano, (un)substituted alkyl, etc.; R5 and R6 are independently H, halogen, (un)substituted alkyl, etc., or R5 and R6 together constitute oxo or form part of an (un)substituted carbocycle; R7a, R8a, R7b R8b, R7c, R8c, R7d, and R8d are independently H, halogen, (un)substituted alkyl, etc., or any two form oxo or form part of an (un)substituted carbocycle or (un)substituted heterocycle, thereby making ring A either a spiro-bicycle or a fused-bicycle or a bridged-bicycle; Ar is (un)substituted aryl or (un)substituted heteroaryl; p = 0-3; and n = 1-4), pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. I can also be used to sensitize a patient that has developed a resistance to other chemotherapeutics. Synthetic procedures for preparing I are exemplified. Example compound II, prepared from intermediates Et 6-oxospiro[2.5]octane-5-carboxylate and 4-(4-(4-chlorophenyl)piperazin-1-yl)butanimidamide, had a PARP 1 inhibition IC50 between 1 nM and 500 nM. The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Application of 1092942-42-1
The Article related to tetrahydroquinazolinone derivative parp inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 1092942-42-1
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica