On July 5, 1988, Kinast, Guenther published a patent.Related Products of 64987-16-2 The title of the patent was Preparation of aminothiazole derivatives as cephalosporin antibiotic intermediates. And the patent contained the following:
The title compounds [I; R1 = (substituted) alkyl, cycloalkyl, (hetero)aryl; R2 = CO2R3; R3, R4 = alkyl, alkenyl, cycloalkyl, cycloalkenyl, (hetero)aryl], useful as intermediates for cephalosporin antibiotics, were prepared from iminothiazolineacetates II. A mixture of Et 2-[(tert-butoxycarbonyl)imino]-3-(tert-butoxycarbonyl)-4-thiazoline-4-acetate, BuLi, and AcH in THF was stirred 2 h at -50 to -60° to give Et 2-[2-[(tert-butoxycarbonyl)amino]thiazol-4-yl]-3-[(tert-butoxycarbonyl)oxybutyrate. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2
The Article related to thiazole amino preparation antibiotic intermediate, cephalosporin intermediate aminothiazole preparation, antibiotic intermediate aminothiazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica