On December 12, 2019, Lo, Wen-Ting; Belabed, Hassane; Haucke, Volker; Nazare, Marc; Kuecuekdisli, Murat published a patent.Application of 64987-16-2 The title of the patent was Preparation of fused pyrimidinones as class II phosphoinositide 3-kinase inhibitors useful in treatment of diseases. And the patent contained the following:
The invention relates to preparation of fused pyrimidinones of formula (I) as class II phosphoinositide 3-kinase inhibitors. Compounds I wherein R1, R2, and R3 each independently is N or C; R4 is H, halo, alkoxy, etc.; R5 can be absent (covalent bond to R6), C1-5 alkyl-cycloalkyl; R6 is H, alkyl, aryl, etc.; R7is S, absent (covalent bond to R8), NR, wherein R is H, etc.; R8 cycloalkyl, C1-5 alkyl, etc.; R9 is amide, amine, urea, etc.; R10 is 5-membered heterocyclyl or heteroaryl (except for pyrazolyl, tetrahydrofurfuryl), preferably a 5-membered aromatic heterocycle comprising one or more of N, O and/or S, etc.; n is 0-5, are claimed. The example compound II was prepared by multistep synthesis starting from Me 3-aminopyrazine-2-carboxylate (procedure given). Compounds I were evaluated for PI3K inhibiting activity (data given). Compounds I can be used as medicaments, in particular for the treatment of a medical condition associated with defective PI3K signalling. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2
The Article related to fused pyrimidinone preparation pi3k inhibitor disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica