On September 30, 2021, Mohamed Teleb, Mohamed A.; Mekky, Ahmed E. M.; Sanad, Sherif M. H. published an article.Formula: C9H8N2S The title of the article was 3-Aminothieno [2,3-b]pyridine-2-carboxylate: Effective precursor for microwave-assisted three components synthesis of new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4( 3H )-one hybrids. And the article contained the following:
In this study, Et 3-aminothieno[2,3-b]pyridine-2-carboxylate was taken as a versatile precursor for the one-pot three-component synthesis of related fused pyrimidine hybrids. The tandem protocol involved the reaction of 3-aminothieno[2,3-b]pyridine, dimethylformamide-dimethylacetal, and amines. The reaction afforded a new series of the target pyrimidine hybrids, linked to different arene units I (X = H, NO2, COOEt, etc.), in good to excellent yields. The prior reaction was evaluated in different solvents under traditional heating or microwave irradiation Moreover, the influence of reaction temperature was also examined The optimal conditions were obtained under microwave irradiation in dioxane at 110°C for 40 to 60 min. Addnl., by repeating the previous tandem reaction using the appropriate amines at reaction times of 20 to 60 min, a new series of pyrimidine hybrids linked to alkyl, arylthiazole, and benzo[d]thiazole units has been prepared in good to excellent yields. Furthermore, the utility of bis(amines) was examined to conduct the synthesis of new bis(pyrimidine) hybrids linked to aliphatic cores, in excellent yields, using the same protocol at 30 min reaction time. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Formula: C9H8N2S
The Article related to pyridothienopyrimidinone hybrid preparation microwave irradiation, aminothienopyridine dmf dimethylacetal amine three component reaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C9H8N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica